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Poole, Elizabeth M.

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Poole

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Elizabeth M.

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Poole, Elizabeth M.
Author's Publications: search.filters.isAuthorOfPublication.3db62199-998f-4114-8ab6-6f408606e185Author: search.filters.author.Amin Al Olama, A.Author: search.filters.author.Aittoma ki, K.Item Type: PublicationHas files: YesSubject: search.filters.subject.breast cancerSubject: search.filters.subject.pleiotropy

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    Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

    (American Association for Cancer Research (AACR), 2016) Kar, S. P.; Beesley, J.; Amin Al Olama, A.; Michailidou, K.; Tyrer, J.; Kote-Jarai, Z.; Lawrenson, K.; Lindstrom, S.; Ramus, S. J.; Thompson, D. J.; Kibel, Adam; Dansonka-Mieszkowska, A.; Michael, A.; Dieffenbach, A. K.; Gentry-Maharaj, A.; Whittemore, A. S.; Wolk, A.; Monteiro, A.; Peixoto, A.; Kierzek, A.; Cox, A.; Rudolph, A.; Gonzalez-Neira, A.; Wu, A. H.; Lindblom, A.; Swerdlow, A.; Ziogas, A.; Ekici, A. B.; Burwinkel, B.; Karlan, B. Y.; Nordestgaard, B. G.; Blomqvist, C.; Phelan, C.; McLean, C.; Pearce, C. L.; Vachon, C.; Cybulski, C.; Slavov, C.; Stegmaier, C.; Maier, C.; Ambrosone, C. B.; Hogdall, C. K.; Teerlink, C. C.; Kang, D.; Tessier, D. C.; Schaid, D. J.; Stram, D. O.; Cramer, Daniel; Neal, D. E.; Eccles, D.; Flesch-Janys, D.; Edwards, D. R. V.; Wokozorczyk, D.; Levine, D. A.; Yannoukakos, D.; Sawyer, E. J.; Bandera, E. V.; Poole, Elizabeth M.; Goode, E. L.; Khusnutdinova, E.; Hogdall, E.; Song, F; Bruinsma, F.; Heitz, F.; Modugno, F.; Hamdy, F. C.; Wiklund, F.; Giles, G. G.; Olsson, H.; Wildiers, H.; Ulmer, H.-U.; Pandha, H.; Risch, H. A.; Darabi, H.; Salvesen, H. B.; Nevanlinna, H.; Gronberg, H.; Brenner, H.; Brauch, H.; Anton-Culver, H.; Song, H.; Lim, H.-Y.; McNeish, I.; Campbell, I.; Vergote, I.; Gronwald, J.; Lubinski, J.; Stanford, J. L.; Benitez, J.; Doherty, J. A.; Permuth, J. B.; Chang-Claude, J.; Donovan, J. L.; Dennis, J.; Schildkraut, J. M.; Schleutker, J.; Hopper, J. L.; Kupryjanczyk, J.; Park, J. Y.; Figueroa, J.; Clements, J. A.; Knight, J. A.; Peto, J.; Cunningham, J. M.; Pow-Sang, J.; Batra, J.; Czene, K.; Lu, K. H.; Herkommer, K.; Khaw, K.-T.; Matsuo, K.; Muir, K.; Offitt, K.; Chen, K.; Moysich, K. B.; Aittoma ki, K.; Odunsi, K.; Kiemeney, L. A.; Massuger, L. F. A. G.; Fitzgerald, L. M.; Cook, L. S.; Cannon-Albright, L.; Hooning, M. J.; Pike, M. C.; Bolla, M. K.; Luedeke, M.; Teixeira, M. R.; Goodman, M. T.; Schmidt, M. K.; Riggan, M.; Aly, M.; Rossing, M. A.; Beckmann, M. W.; Moisse, M.; Sanderson, M.; Southey, M. C.; Jones, M.; Lush, M.; Hildebrandt, M. A. T.; Hou, M.-F.; Schoemaker, M. J.; Garcia-Closas, M.; Bogdanova, N.; Rahman, N.; Le, N. D.; Orr, N.; Wentzensen, N.; Pashayan, N.; Peterlongo, P.; Guenel, P.; Brennan, P.; Paulo, P.; Webb, P. M.; Broberg, P.; Fasching, P. A.; Devilee, P.; Wang, Q.; Cai, Q.; Li, Q.; Kaneva, R.; Butzow, R.; Kopperud, R. K.; Schmutzler, R. K.; Stephenson, R. A.; MacInnis, R. J.; Hoover, R. N.; Winqvist, R.; Ness, R.; Milne, R. L.; Travis, R. C.; Benlloch, S.; Olson, S. H.; McDonnell, S. K.; Tworoger, Shelley; Maia, S.; Berndt, S.; Lee, S. C.; Teo, S.-H.; Thibodeau, S. N.; Bojesen, S. E.; Gapstur, S. M.; Kjaer, S. K.; Pejovic, T.; Tammela, T. L. J.; Do rk, T.; Bru ning, T.; Wahlfors, T.; Key, T. J.; Edwards, T. L.; Menon, U.; Hamann, U.; Mitev, V.; Kosma, V.-M.; Setiawan, V. W.; Kristensen, V.; Arndt, V.; Vogel, W.; Zheng, W.; Sieh, W.; Blot, W. J.; Kluzniak, W.; Shu, X.-O.; Gao, Y.-T.; Schumacher, F.; Freedman, M. L.; Berchuck, A.; Dunning, A. M.; Simard, J.; Haiman, C. A.; Spurdle, A.; Sellers, T. A.; Hunter, David; Henderson, B. E.; Kraft, Peter; Chanock, S. J.; Couch, F. J.; Hall, P.; Gayther, S. A.; Easton, D. F.; Chenevix-Trench, G.; Eeles, R.; Pharoah, P. D. P.; Lambrechts, D.; undefined, undefined

    Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis.