Person: Sung, Chang Kyoo
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Chang Kyoo
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Sung, Chang Kyoo
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Publication Production of a Natural Antibody to the Mouse Polyoma Virus Is a Multigenic Trait(Genetics Society of America, 2012) Andrews, Erik; Velupillai, Palanivel; Sung, Chang Kyoo; Beier, D; Benjamin, ThomasMA/MyJ mice express a natural antibody to the highly oncogenic polyoma virus. C57BR/cdJ mice lack this antibody but mount an adaptive T-cell response to the virus. Analysis of F2 progeny of a cross between these strains reveals a pattern of inheritance of expression of the natural antibody involving two genes in an epistatic relationship.Publication The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC(Public Library of Science, 2012) Sung, Chang Kyoo; Yim, Hyungshin; Gu, Hongcang; Li, Dawei; Andrews, Erik; Duraisamy, Sekhar; Li, Cheng; Drapkin, Ronny; Benjamin, Thomasp150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types.