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Chu, Yun

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Chu

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Chu, Yun
Author's Publications: search.filters.isAuthorOfPublication.4c56b750-9b66-4212-a68c-d5f42648c169

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    Protein kinase C is a calcium sensor for presynaptic short-term plasticity
    (eLife Sciences Publications, Ltd, 2014) Fioravante, Diasynou; Chu, Yun; de Jong, Arthur PH; Leitges, Michael; Kaeser, Pascal; Regehr, Wade
    In presynaptic boutons, calcium (Ca2+) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca2+ to their C2 domains, the proteins that sense smaller global Ca2+ increases to produce short-term plasticity have remained elusive. Here, we identify a Ca2+ sensor for post-tetanic potentiation (PTP), a form of plasticity thought to underlie short-term memory. We find that at the functionally mature calyx of Held synapse the Ca2+-dependent protein kinase C isoforms α and β are necessary for PTP, and the expression of PKCβ in PKCαβ double knockout mice rescues PTP. Disruption of Ca2+ binding to the PKCβ C2 domain specifically prevents PTP without impairing other PKCβ-dependent forms of synaptic enhancement. We conclude that different C2-domain-containing presynaptic proteins are engaged by different Ca2+ signals, and that Ca2+ increases evoked by tetanic stimulation are sensed by PKCβ to produce PTP. DOI: http://dx.doi.org/10.7554/eLife.03011.001
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    Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
    (2013) Tsai, Peter Tzu-shin; Hull, Court; Chu, Yun; Greene-Colozzi, Emily; Sadowski, Abbey R.; Leech, Jarrett M.; Steinberg, Jason; Crawley, Jacqueline N.; Regehr, Wade; Sahin, Mustafa