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Wilkinson, Jeremy

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Wilkinson, Jeremy

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    Overview of the Microbiome Among Nurses study (Micro-N) as an example of prospective characterization of the microbiome within cohort studies
    (Springer Science and Business Media LLC, 2021-04-21) Song, Mingyang; Everett, Christine; Li, Chengchen; Wilkinson, Jeremy; Nguyen, Long; McIver, Lauren; Ivey, Kerry; Izard, Jacques; Palacios, Natalia; Eliassen, A; Willett, Walter; Ascherio, Alberto; Sun, Qi; Tworoger, Shelley; Chang, Andrew; Garrett, Wendy; Huttenhower, Curtis; Rimm, Eric
    A lack of prospective studies has been a major barrier for assessing the role of the microbiome in human health and disease on a population-wide scale. To address this significant knowledge gap, we have launched a large-scale collection targeting fecal and oral microbiome specimens from 20,000 women within the Nurses’ Health Study II cohort (the Microbiome among Nurses, or Micro-N study). Leveraging the rich epidemiologic data that have been repeatedly collected from this cohort since 1989; the established biorepository of archived blood, urine, buccal cell, and tumor tissue specimens; the available genetic and biomarker data; the cohort's ongoing follow-up; and the BIOM-Mass microbiome research platform, Micro-N furnishes unparalleled resources for future prospective studies to interrogate the interplay between host, environmental factors, and the microbiome in human health. These prospectively collected materials will provide much-needed evidence to infer causality in microbiome-associated outcomes, paving the way towards development of microbiota-targeted modulators, preventives, diagnostics and therapeutics. Here, we describe a generalizable, scalable and cost-effective platform used for stool and oral microbiome specimen and metadata collection in the Micro-N study as an example of how prospective studies of the microbiome may be carried out.