Person:

Quan, Qimin

Manipulation of light at the nanoscale has the promise to enable numerous technological advances in biomedical sensing, optical communications, nano-mechanics and quantum optics. As photons have vanishingly small interaction cross sections, their interactions have to be mitigated by matters (i.e. quantum emitters, molecules, electrons etc.). Waveguides and cavities are the fundamental building blocks of the optical circuits, which control or confine light to specific matters of interest. The first half of the thesis (Chapters 2 & 3) focuses on how to design various photonic nanostructures to manipulate light on nano- to micro- scale, especially to modify the light-matter interaction properties. Chapter 2 discusses how nano-slot waveguides and photonic crystal nanobeam waveguides are able to modify the emission of quantum emitters, in a different way that normal ridge waveguides are not able to. Chapter 3 focuses on a more complicated and powerful structure: the photonic crystal nanobeam cavity. The design, fabrication and characterization of the photonic crystal nanobeam cavities are described and demonstrated in detail, which lays out the foundation of the biomedical sensing applications in the second half of the thesis. The second half of the thesis (Chapters 4 & 5) focuses on the application of photonic crystal nanobeam cavities in the label-free sensing of biomedical substances. Chapter 4 demonstrates detection of solutions with different refractive index (aceton, methanol, IPA etc.), glucose concentration, single polystyrene nanoparticles and single streptavidin bio-molecules. Chapter 4 proposes a novel nonlinear optical method to further enhance the sensitivity. Chapter 4 also demonstrates high quality nanobeam cavities fabricated in polymers, that open up a new route to decrease the cost, as well as to achieve novel applications with functional polymers. The broader impact of this technology lies in its potential of commercialization of a new generation of biosensors with high sensitivity and high integration. Chapter 5 discusses progresses towards instrumentation of the nanobeam cavity sensing technology for research & development apparatus, as well as point-of-care diagnostic tools.

Fluorescent labeling techniques have been widely used in live cell studies; however, the labeling processes can be laborious and challenging for use in non-transfectable cells, and labels can interfere with protein functions. While label-free biosensors have been realized by nanofabrication, a method to track intracellular protein dynamics in real-time, in situ and in living cells has not been found. Here we present the first demonstration of label-free detection of intracellular p53 protein dynamics through a nanoscale surface plasmon-polariton fiber-tip-probe (FTP).

We demonstrate an integrated nanophotonic network in diamond, consisting of a ring resonator coupled to an optical waveguide with grating in- and outcouplers. Using a nitrogen-vacancy color center embedded inside the ring resonator as a source of photons, single photon generation and routing at room temperature is observed. Furthermore, we observe a large overall photon extraction efficiency (10%) and high quality factors of ring resonators (3200 for waveguide-coupled system and 12 600 for a bare ring).

A variety of nanoscale photonic, mechanical, electronic, and optoelectronic devices require scalable thin film fabrication. Typically, the device layer is defined by thin film deposition on a substrate of a different material, and optical or electrical isolation is provided by the material properties of the substrate or by removal of the substrate. For a number of materials this planar approach is not feasible, and new fabrication techniques are required to realize complex nanoscale devices. Here, we report a three-dimensional fabrication technique based on anisotropic plasma etching at an oblique angle to the sample surface. As a proof of concept, this angled-etching methodology is used to fabricate free-standing nanoscale components in bulk single-crystal diamond, including nanobeam mechanical resonators, optical waveguides, and photonic crystal and microdisk cavities. Potential applications of the fabricated prototypes range from classical and quantum photonic devices to nanomechanical-based sensors and actuators.

The realization of efficient optical interfaces for solid-state atom-like systems is an important problem in quantum science with potential applications in quantum communications and quantum information processing. We describe and demonstrate a technique for coupling single nitrogen vacancy (NV) centers to suspended diamond photonic crystal cavities with quality factors up to 6000. Specifically, we present an enhancement of the NV center’s zero-phonon line fluorescence by a factor of 7 in low-temperature measurements.

We demonstrate that a slot waveguide provides a broadband loss-free platform suitable for applications in quantum optics. We find that strong coupling between light quanta and a single quantum emitter placed in the waveguide slot can be achieved with efficiency higher than 96% and Purcell factor (spontaneous emission factor) larger than 200. The proposed system is a promising platform for quantum information processing and can be used to realize an efficient single photon source and optically addressable photon register.

We report exceptionally low thresholds (9.1 μJ/cm2) for room temperature lasing at ∼450 nm in optically pumped Gallium Nitride (GaN) nanobeam cavity structures. The nanobeam cavity geometry provides high theoretical Q (>100 000) with small modal volume, leading to a high spontaneous emission factor, β = 0.94. The active layer materials are Indium Gallium Nitride (InGaN) fragmented quantum wells (fQWs), a critical factor in achieving the low thresholds, which are an order-of-magnitude lower than obtainable with continuous QW active layers. We suggest that the extra confinement of photo-generated carriers for fQWs (compared to QWs) is responsible for the excellent performance.

Current methods to study molecular interactions require labeling the subject molecules with fluorescent reporters. The effect of the fluorescent reporters on molecular dynamics, however, has not been quantified due to lack of alternative methods. We develop a hybrid photonic-plasmonic antenna-in-a-nanovacity single molecule biosensor to study DNA-protein dynamics without using fluorescent labels. Our results indicate that the fluorescein and fluorescent protein labels will decrease the interaction between a single DNA and a protein due to weakened electrostatic interaction. While the study is performed on the DNA-XPA system, the conclusion has a generall implication that the traditional fluorescent labeling methods might be misestimating the molecular interactions.