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Chang, Huibin

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Chang

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Chang, Huibin
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    High-Throughput Coating With Biodegradable Antimicrobial Pullulan Fibres Extends Shelf Life and Reduces Weight Loss in an Avocado Model
    (Springer Science and Business Media LLC, 2022-06-20) Chang, Huibin; Xu, Jie; MacQueen, Luke; Aytac, Zeynep; Peters, Michael; Zimmerman, John; Xu, Tao; Demokritou, Philip; Parker, Kevin
    Food waste and food safety motivate the need for improved food packaging solutions. However, current films/coatings addressing these issues are often limited by inefficient release dynamics that require large quantities of active ingredients. Here, we developed antimicrobial pullulan fiber (APFs) based packaging that are biodegradable and capable of wrapping food substrates, increasing their longevity and food safety. APFs were spun using a high-throughput system termed focused rotary jet spinning (FRJS) with water as the only solvent, allowing the incorporation of nature-derived antimicrobial agents. Using avocados as a representative example, we demonstrate that APF-coated samples had their shelf life extended by inhibited proliferation of natural microflora, as well as reduced weight loss compared to uncoated control samples. This work offers a promising technique to produce scalable, low cost and environmentally friendly biodegradable antimicrobial packaging systems.
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    Recreating the heart’s helical structure-function relationship with focused rotary jet spinning
    (American Association for the Advancement of Science (AAAS), 2022-07-08) Chang, Huibin; Liu, Qihan; Zimmerman, John F.; Lee, Keel Yong; Jin, Qianru; Peters, Michael M.; Rosnach, Michael; Choi, Suji; Kim, Sean L.; Ardoña, Herdeline Ann M.; MacQueen, Luke A.; Chantre, Christophe O.; Motta, Sarah E.; Cordoves, Elizabeth M.; Parker, Kevin
    Helical alignments within the heart’s musculature have been speculated to be important in achieving physiological pumping efficiencies. Testing this possibility is difficult, however, because it is challenging to reproduce the fine spatial features and complex structures of the heart’s musculature using current techniques. Here we report focused rotary jet spinning (FRJS), an additive manufacturing approach that enables rapid fabrication of micro/nanofiber scaffolds with programmable alignments in three-dimensional geometries. Seeding these scaffolds with cardiomyocytes enabled the biofabrication of tissue-engineered ventricles, with helically aligned models displaying more uniform deformations, greater apical shortening, and increased ejection fractions compared with circumferential alignments. The ability of FRJS to control fiber arrangements in three dimensions offers a streamlined approach to fabricating tissues and organs, with this work demonstrating how helical architectures contribute to cardiac performance.