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Nan, Hongmei

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Hongmei

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Nan, Hongmei

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2008 - 20092

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Author's Publications: search.filters.isAuthorOfPublication.6149c6b6-5279-4ed7-8920-02bed4a46d19

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    A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
    (Public Library of Science, 2008) Kraft, Peter; Guo, Qun; Qureshi, Abrar; Duffy, David L.; Montgomery, Grant W.; Hayward, Nicholas K.; Thomas, Gilles; Hoover, Robert N.; Chanock, Stephen; Han, Jiali; Nan, Hongmei; Turman, Constance; Hankinson, Susan; Hu, Frank; Zhao, Zhen Zhen; Martin, Nicholas G.; Hunter, David
    We conducted a multi-stage genome-wide association study of natural hair color in more than 10,000 men and women of European ancestry from the United States and Australia. An initial analysis of 528,173 single nucleotide polymorphisms (SNPs) genotyped on 2,287 women identified IRF4 and SLC24A4 as loci highly associated with hair color, along with three other regions encompassing known pigmentation genes. We confirmed these associations in 7,028 individuals from three additional studies. Across these four studies, SLC24A4 rs12896399 andIRF4 rs12203592 showed strong associations with hair color, with \(p = 6.0×10^{−62}\) and \(p = 7.46×10^{−127}\), respectively. The IRF4 SNP was also associated with skin color \((p = 6.2×10^{−14})\), eye color \((p = 6.1×10^{−13})\), and skin tanning response to sunlight \((p = 3.9×10^{−89})\). A multivariable analysis pooling data from the initial GWAS and an additional 1,440 individuals suggested that the association between rs12203592 and hair color was independent of rs1540771, a SNP between the IRF4 and EXOC2 genes previously found to be associated with hair color. After adjustment for rs12203592, the association between rs1540771 and hair color was not significant (p = 0.52). One variant in the MATP gene was associated with hair color. A variant in the HERC2 gene upstream of the OCA2 gene showed the strongest and independent association with hair color compared with other SNPs in this region, including three previously reported SNPs. The signals detected in a region around the MC1R gene were explained byMC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation.
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    Genetic Variants in FGFR2 and FGFR4 Genes and Skin Cancer Risk in the Nurses' Health Study
    (BioMed Central, 2009) Nan, Hongmei; Qureshi, Abrar A; Hunter, David; Han, Jiali
    Background: The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers. Methods: We evaluated the associations of four genetic variants in the FGFR2 gene highly related to breast cancer risk and the three common tag-SNPs in the FGFR4 gene with skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 controls. Results: We found no evidence for associations between these seven genetic variants and the risks of melanoma and nonmelanocytic skin cancer. Conclusion: Given the power of this study, we did not detect any contribution of genetic variants in the FGFR2 or FGFR4 genes to inherited predisposition to skin cancer among Caucasian women.