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Arellano, Ronald

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Arellano

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Arellano, Ronald

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Author's Publications: search.filters.isAuthorOfPublication.66b3d532-9513-44e0-b877-074e7c815dd7

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    A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors
    (Elsevier BV, 2014) Hong, Theodore; Delaney, Thomas; Mamon, Harvey; Willett, Christopher G.; Yeap, Beow; Niemierko, Andrzej; Wolfgang, John; Lu, Hsiao-Ming; Adams, Judith; Weyman, Elizabeth A.; Arellano, Ronald; Blaszkowsky, Lawrence; Allen, Jill; Tanabe, Kenneth; Ryan, David; Zhu, Andrew
    Purpose To evaluate the feasibility of a respiratory-gated proton beam therapy for liver tumors. Materials and Methods Fifteen patients were enrolled on a prospective IRB-approved protocol. Eligibility criteria included Childs-Pugh A/B cirrhosis, unresectablebiopsy-proven hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), or metastatic disease (solid tumors only), 1-3 lesions, and tumor size of ≤6 cm. Patients received 15 fractions to a total dose of 45-75 GyE using respiratory-gated proton beam therapy. Gating was performed with an external respiratory position monitoring (RPM) based system. Results Of the15 patients enrolled on this clinical trial, 11 had HCC, 3 had ICC, and 1had metastasis from another primary. Ten patients had a single lesion, 3 patients had 2 lesions, and 2 patients 3 lesions. Toxicities were: Gr 3 bilirubinemia- 2, Gr 3 gastrointestinal bleed- 1, and Gr 5 stomach perforation-1. One patient had a marginal recurrence, 3 had hepatic recurrences elsewhere in the liver, and 2 had extrahepatic recurrence. With a median follow-up for survivors of 69 months, 1-yr, 2-yr, 3-yr OS is 53%, 40%, and 33% respectively. PFS is 40%,33% and 27% at 1, 2, and 3 years, respectively. Conclusion Respiratory-gated proton beam therapy for liver tumors is feasible. Phase II studies for primary liver tumors and metastatic tumorsare underway.