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Posada, Jessica

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Posada

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Posada, Jessica

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    Non-Invasive Monitoring of Chronic Liver Disease via Near-Infrared and Shortwave-Infrared Imaging of Endogenous Lipofuscin
    (Springer Science and Business Media LLC, 2020-08) Saif, Mari; Kwanten, Wilhelmus J.; Carr, Jessica A.; Chen, Ivy X.; Posada, Jessica; Srivastava, Amitabh; Zhang, Juanye; Zheng, Yi; Pinter, Matthias; Chatterjee, Sampurna; Softic, Samir; Kahn, C.; van Leyen, Klaus; Bruns, Oliver T.; Jain, Rakesh; Bawendi, Moungi G.
    Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fluorescence of lipofuscin can be used to monitor the progression and regression of liver necroinflammation and fibrosis in mouse models of non-alcoholic fatty liver disease and advanced fibrosis, as well as to detect non-alcoholic steatohepatitis and cirrhosis in biopsied samples of human liver tissue.