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Mutter, George

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Mutter

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Mutter, George

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2011 - 20162

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Author's Publications: search.filters.isAuthorOfPublication.700f484e-3082-4abc-858b-bbe7201d8763Start date: 2011End date: 2016

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    Endometrial Intraepithelial Neoplasia Clinical Correlates and Outcomes

    (Ovid Technologies (Wolters Kluwer Health), 2011) Semere, Luwam G.; Ko, Emily; Johnson, Natasha; Vitonis, Allison F.; Phang, Laura J.; Cramer, Daniel; Mutter, George

    Objective

    To estimate cancer outcome and outcome predictors of women with endometrial intraepithelial neoplasia (EIN).

    Methods

    Outcomes of women with first diagnosis of EIN (“index biopsy”) was determined by follow-up pathology. Patient characteristics were correlated with EIN regression, EIN persistence, and progression to cancer.

    Results

    Fifteen percent (9.8-20.8%, 26/177) of index EIN biopsies had concurrent cancer. Of the women with cancer-free index EIN biopsies, and follow-up by hysterectomy or more than 18 months surveillance, 25% (18.4-33.3%, 36/142) showed regression, 35% (27.4-43.7%, 50/142) persistence, and 39% (31.3-48.0%, 56/142) progression. Non-white ethnicity and progestin treatment reduced cancer outcomes (OR 0.16 (0.03,0.84) and 0.24 (0.08, 0.70) respectively), while body mass index (BMI) greater than 25 increased malignant outcomes (BMI 25 or higher, OR 3.05 (1.10,8.45)).

    Conclusion

    EIN confers a high risk of cancer, but individual patient outcomes cannot be predicted. Management should include exclusion of concurrent carcinoma and consideration of hysterectomy.

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    Toxicology Study of Single-walled Carbon Nanotubes and Reduced Graphene Oxide in Human Sperm

    (Nature Publishing Group, 2016) Asghar, Waseem; Shafiee, Hadi; Velasco, Vanessa; Sah, Vasu R.; Guo, Shirui; El Assal, Rami; Inci, Fatih; Rajagopalan, Adhithi; Jahangir, Muntasir; Anchan, Raymond; Mutter, George; Ozkan, Mihrimah; Ozkan, Cengiz S.; Demirci, Utkan

    Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have not been fully examined. Additionally, it is not clear whether the nanomaterial exposure has any effect on sperm sorting procedures used in clinical settings. Here, we show that the presence of functionalized single walled carbon nanotubes (SWCNT-COOH) and reduced graphene oxide at concentrations of 1–25 μg/mL do not affect sperm viability. However, SWCNT-COOH generate significant reactive superoxide species at a higher concentration (25 μg/mL), while reduced graphene oxide does not initiate reactive species in human sperm. Further, we demonstrate that exposure to these nanomaterials does not hinder the sperm sorting process, and microfluidic sorting systems can select the sperm that show low oxidative stress post-exposure.