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Akbari, Ali

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Akbari

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Ali

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Akbari, Ali

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2020 - 20253

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Author's Publications: search.filters.isAuthorOfPublication.71ad7a4a-39c9-49d1-a3cd-0cc0cdb634cd

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    The genetic origin of the Indo-Europeans
    (Springer Science and Business Media LLC, 2025-02-05) Lazaridis, Iosif; Olalde, Iñigo; Khokhlov, Alexander A.; Kitov, Egor P.; Shishlina, Natalia I.; Ailincăi, Sorin C.; Agapov, Danila S.; Agapov, Sergey A.; Batieva, Elena; Bauyrzhan, Baitanayev; Bereczki, Zsolt; Buzhilova, Alexandra; Changmai, Piya; Chizhevsky, Andrey A.; Ciobanu, Ion; Constantinescu, Mihai; Csányi, Marietta; Dani, János; Dashkovskiy, Peter K.; Évinger, Sándor; Faifert, Anatoly; Flegontov, Pavel; Frînculeasa, Alin; Frînculeasa, Mădălina N.; Hajdu, Tamás; Higham, Tom; Jarosz, Paweł; Jelínek, Pavol; Khartanovich, Valeri I.; Kirginekov, Eduard N.; Kiss, Viktória; Kitova, Alexandera; Kiyashko, Alexeiy V.; Koledin, Jovan; Korolev, Arkady; Kosintsev, Pavel; Kulcsár, Gabriella; Kuznetsov, Pavel; Magomedov, Rabadan; Mamedov, Aslan M.; Melis, Eszter; Moiseyev, Vyacheslav; Molnár, Erika; Monge, Janet; Negrea, Octav; Nikolaeva, Nadezhda A.; Novak, Mario; Ochir-Goryaeva, Maria; Pálfi, György; Popovici, Sergiu; Rykun, Marina P.; Savenkova, Tatyana M.; Semibratov, Vladimir P.; Seregin, Nikolai N.; Šefčáková, Alena; Mussayeva, Raikhan S.; Shingiray, Irina; Shirokov, Vladimir N.; Simalcsik, Angela; Sirak, Kendra; Solodovnikov, Konstantin N.; Tárnoki, Judit; Tishkin, Alexey A.; Trifonov, Viktor; Vasilyev, Sergey; Candilio, Francesca; Cheronet, Olivia; Flegontova, Olga; Keating, Denise; Lawson, Ann Marie; Oppenheimer, Jonas; Qiu, Lijun; Workman, J. Noah; Zalzala, Fatma; Szécsényi-Nagy, Anna; Palamara, Pier Francesco; Mallick, Swapan; Rohland, Nadin; Pinhasi, Ron; Anthony, David; Vyazov, Leonid; Fournier, Romain; Ringbauer, Harald; Akbari, Ali; Brielle, Esther; Callan, Kimberly; Curtis, Elizabeth; Iliev, Lora; Kearns, Aisling; Mah, Matthew; Micco, Adam; Michel, Megan; Reich, David
    The Yamnaya archaeological complex appeared around 3300 BCE across the steppes north of the Black and Caspian Seas, and by 3000 BCE reached its maximal extent from Hungary in the west to Kazakhstan in the east. To localize Yamnaya origins among preceding Eneolithic people, we assembled ancient DNA from 428 individuals, demonstrating three genetic clines. A “Caucasus-Lower Volga” (CLV) Cline suffused with Caucasus hunter-gatherer1 ancestry extended between a Caucasus Neolithic southern end, and a northern end at Berezhnovka along the Lower Volga river. Bidirectional gene flow created intermediate populations, such as north Caucasus Maikop people, and those at Remontnoye on the steppe. The “Volga Cline” was formed as CLV people mixed with upriver populations of Eastern hunter-gatherer2 ancestry, creating hyper-variable groups as at Khvalynsk. The “Dnipro Cline” was formed as CLV people moved west, mixing with Ukraine Neolithic hunter-gatherers3 along the Dnipro river to establish Serednii Stih groups from whom Yamnaya ancestors formed around 4000 BCE and grew explosively after 3750-3350 BCE. CLV people contributed four-fifths of the ancestry of the Yamnaya, and, entering Anatolia likely from the east, at least a tenth of the ancestry of Bronze Age Central Anatolians, where Hittite was spoken4,5. We thus propose that the final unity of the speakers of “Proto-Indo-Anatolian”, the language ancestral to both Anatolian and Indo-European, was among CLV people sometime between 4400-4000 BCE.
  • No Thumbnail Available
    Publication
    A positively selected FBN1 missense variant reduces height in Peruvian individuals
    (Springer Science and Business Media LLC, 2020-05-13) Asgari, Samira; Luo, Yang; Akbari, Ali; Belbin, Gillian M.; Li, Xinyi; Harris, Daniel N.; Selig, Martin; Bartell, Eric; Calderon, Roger; Slowikowski, Kamil; Contreras, Carmen; Yataco, Rosa; Galea, Jerome; Jimenez, Judith; Coit, Julia; Farroñay, Chandel; Nazarian, Rosalynn; O’Connor, Timothy D.; Dietz, Harry C.; Hirschhorn, Joel; Guio, Heinner; Lecca, Leonid; Kenny, Eimear E.; Freeman, Esther E.; Murray, Megan B.; Raychaudhuri, Soumya; Murray
    On average, the Peruvian population is among the shortest in the world1. Here we show that Native American ancestry is associated with reduced height in an ethnically diverse group of Peruvians, and identify a novel, population-specific, missense variant in FBN1 (E1297G) that is significantly associated with lower height. Each copy of the minor allele (frequency=4.7%) reduces height by 2.2 cm (4.4 cm in homozygous individuals). This is the largest effect size known for a common height-associated variant. FBN1 encodes the extracellular matrix protein fibrillin-1, a major structural component of microfibrils. We observed less densely packed fibrillin-1-rich microfibrils with irregular edges in the skin of individuals homozygous for G1297 compared to individuals homozygous for E1297. Moreover, we show that E1297G locus is under positive selection in non-African populations, and the E1297 variant shows subtle evidence of positive selection within the Peruvian population specifically. This variant is also significantly more frequent in coastal Peruvian populations than in populations from the Andes or the Amazon, suggesting that short stature might be the result of adaptation to factors associated with the coastal environment in Peru.
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    Publication
    Large-Scale Migration into Britain During the Middle to Late Bronze Age
    (SpringerNature, 2021-12-22) Patterson, Nicholas; Isakov, Michael; Booth, Thomas; Büster, Lindsey; Fischer, Claire-Elise; Olalde, Inigo; Ringbauer, Harald; Akbari, Ali; Cheronet, Olivia; Bleasdale, Madeleine; Adamski, Nicole; Altena, Eveline; Bernardos, Rebecca; Brace, Selina; Broomandkhoshbacht, Nasreen; Callan, Kimberly; Candilio, Francesca; Culleton, Brendan; Curtis, Elizabeth; Demetz, Lea; Carlson, Kellie; Edwards, C.; Fernandes, Daniel M.; Foody, M. George B.; Freilich, Suzanne; Goodchild, Helen; Kearns, Aisling; Lawson, Ann Marie; Lazaridis, Iosif; Mah, Matthew; Mallick, Swapan; Mandl, Kirsten; Micco, Adam; Michel, Megan; Morante, Guillermo Bravo; Oppenheimer, Jonas; Özdoğan, Kadir Toykan; Qiu, Lijun; Schattke, Constanze; Stewardson, Kristin; Workman, James; Zalzala, Fatma; Zhang, Zhao; Agustí, Bibiana; Allen, Tim; Almássy, Katalin; Amkreutz, Luc; Ash, Abigail; Baillif-Ducros, Christèle; Barclay, Alistair; Bartosiewicz, László; Baxter, Katherine; Bernert, Zsolt; Blažek, Jan; Bodružić, Mario; Boissinot, Philippe; Bonsall, Clive; Bradley, Pippa; Brittain, Marcus; Brookes, Alison; Brown, Fraser; Brown, Lisa; Budd, Chelsea; Burmaz, Josip; Canet, Sylvain; Carnicero-Cáceres, Silvia; Čaušević-Bully, Morana; Chamberlain, Andrew; Chauvin, Sébastien; Clough, Sharon; Čondić, Natalija; Coppa, Alfredo; Craig, Oliver; Črešnar, Matija; Cummings, Vicki; Czifra, Szabolcs; Danielisová, Alžběta; Daniels, Robin; Davies, Alex; de Jersey, Philip; Deacon, Jody; Deminger, Csilla; Ditchfield, Peter W.; Dizdar, Marko; Dobeš, Miroslav; Dobisíková, Miluše; Domboróczki, László; Drinkall, Gail; Đukić, Ana; Ernée, Michal; Evans, Christopher; Evans, Jane; Fernández-Götz, Manuel; Filipović, Slavica; Fitzpatrick, Andrew; Fokkens, Harry; Fowler, Chris; Fox, Allison; Gallina, Zsolt; Gamble, Michelle; González Morales, Manuel R.; González-Rabanal, Borja; Green, Adrian; Gyenesei, Katalin; Habermehl, Diederick; Hajdu, Tamás; Hamilton, Derek; Harris, James; Hayden, Chris; Hendriks, Joep; Hernu, Bénédicte; Hey, Gill; Horňák, Milan; Ilon, Gábor; Istvánovits, Eszter; Jones, Andy M.; Blečić Kavur, Martina; Kazek, Kevin; Kenyon, Robert A.; Khreisheh, Amal; Kiss, Viktória; Kleijne, Jos; Knight, Mark; Kootker, Lisette M.; Kovács, Péter F.; Kozubová, Anita; Kulcsár, Gabriella; Kulcsár, Valéria; Le Pennec, Christophe; Legge, Michael; Leivers, Matt; Loe, Louise; López-Costas, Olalla; Lord, Tom; Los, Dženi; Lyall, James; Marín-Arroyo, Ana B.; Mason, Philip; Matošević, Damir; Maxted, Andy; McIntyre, Lauren; McKinley, Jacqueline; McSweeney, Kathleen; Meijlink, Bernard; Mende, Balázs G.; Menđušić, Marko; Metlička, Milan; Meyer, Sophie; Mihovilić, Kristina; Milasinovic, Lidija; Minnitt, Steve; Moore, Joanna; Morley, Geoff; Mullan, Graham; Musilová, Margaréta; Neil, Benjamin; Nicholls, Rebecca; Novak, Mario; Pala, Maria; Papworth, Martin; Paresys, Cécile; Patten, Ricky; Perkić, Domagoj; Pesti, Krisztina; Petit, Alba; Petriščáková, Katarína; Pichon, Coline; Pickard, Catriona; Pilling, Zoltán; Price, T. Douglas; Radović, Siniša; Redfern, Rebecca; Resutík, Branislav; Rhodes, Daniel T.; Richards, Martin B.; Roberts, Amy; Roefstra, Jean; Sankot, Pavel; Šefčáková, Alena; Sheridan, Alison; Skae, Sabine; Šmolíková, Miroslava; Somogyi, Krisztina; Somogyvári, Ágnes; Stephens, Mark; Szabó, Géza; Szécsényi-Nagy, Anna; Szeniczey, Tamás; Tabor, Jonathan; Tankó, Károly; Tavarez Maria, Clenis; Terry, Rachel; Teržan, Biba; Teschler-Nicola, Maria; Torres-Martínez, Jesús F.; Trapp, Julien; Turle, Ross; Ujvári, Ferenc; van der Heiden, Menno; Veleminsky, Petr; Veselka, Barbara; Vytlačil, Zdeněk; Waddington, Clive; Ware, Paula; Wilkinson, Paul; Wilson, Linda; Wiseman, Rob; Young, Eilidh; Zaninović, Joško; Žitňan, Andrej; Lalueza-Fox, Carles; de Knijff, Peter; Barnes, Ian; Halkon, Peter; Thomas, Mark G.; Kennett, Douglas J.; Cunliffe, Barry; Lillie, Malcolm; Rohland-Pinello, Nadin; Pinhasi, Ron; Armit, Ian; Reich, David
    Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age1. To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000-875 BCE, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across Central and Western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and Britain’s independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in Central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in Central Europe over this period.