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Jung, Keehoon

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Jung

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Keehoon

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Jung, Keehoon
Author's Publications: search.filters.isAuthorOfPublication.7d1eaf69-443a-46f0-9200-5020af6faadc

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    Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2
    (American Association for the Advancement of Science (AAAS), 2018) Incio, Joao; Ligibel, Jennifer; McManus, Daniel T.; Suboj, Priya; Jung, Keehoon; Kawaguchi, Kosuke; Pinter, Matthias; Babykutty, Suboj; Chin, Shan M.; Vardam, Trupti; Huang, Yuhui; Rahbari, Nuh N.; Roberge, Sylvie; Wang, Dannie; Gomes-Santos, Igor L.; Puchner, Stefan B.; Schlett, Christopher L.; Hoffmman, Udo; Ancukiewicz, Marek; Tolaney, Sara; Krop, Ian; Duda, Dan; Boucher, Yves; Fukumura, Dai; Jain, Rakesh
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    Live Images of Donor Dendritic Cells Trafficking via CX3CR1 Pathway
    (Frontiers Media S.A., 2016) Ueno, Takuya; Kim, Pilhan; McGrath, Martina; Yeung, Melissa; Shimizu, Tetsunosuke; Jung, Keehoon; Sayegh, Mohamed; Chandraker, Anil; Abdi, Reza; Yun, Seok H.
    Background: A number of studies have demonstrated the role of CX3CR1 in regulating the migration of monocytes into peripheral tissue and their transformation into dendritic cell (DC). No data are yet available on the importance of chemokine pathways in regulating homeostasis of DC in heart transplants. Recently, we showed that recipients of heart allografts from CX3CR1−/− donors show longer survival. To assess the trafficking of dDC, we have developed and tested a novel in vivo imaging tool in CX3CR1GFP/+ DC (B6 background) heart graft into BALB/c recipient model. Results: Majority of GFP+ cells were noted in the middle of cardiac myocyte. However few hours post transplant, they experienced morphological changes including stretching their extensions (3 and 24 h). However, images from 72 h at cardiac graft showed many of GFP+ cells moved to vessel areas. GFP+ cells were detected in near vessel wall. Only one GFP+ cell was observed in three lymph nodes (two mesenteric and one inguinal) (72 h). Conclusion: Our data indicate that immediately post transplant dDC undergo morphological changes and traffic out of the organs via systemic circulation. While, we still noted presence of dDC in the transplanted organs, their trafficking to lymphoid tissue remains to be fully explored.
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    Solid stress and elastic energy as measures of tumour mechanopathology
    (Springer Nature, 2016) Nia, Hadi; Jain, Rakesh; Liu, Hao; Seano, Giorgio; Datta, Meenal; Jones, Dennis; Rahbari, Nuh; Incio, Joao; Chauhan, Vikash; Jung, Keehoon; Martin, John D.; Askoxylakis, Vasileios; Padera, Timothy; Fukumura, Dai; Boucher, Yves; Hornicek, Francis; Grodzinsky, Alan J; Baish, James W; Munn, Lance
    Solid stress and tissue stiffness affect tumour growth, invasion, metastasis and treatment. Unlike stiffness, which can be precisely mapped in tumours, the measurement of solid stresses is challenging. Here, we show that two-dimensional spatial mappings of solid stress and the resulting elastic energy in excised or in situ tumours with arbitrary shapes and wide size ranges can be obtained via three distinct and quantitative techniques that rely on the measurement of tissue displacement after disruption of the confining structures. Application of these methods in models of primary tumours and metastasis revealed that: (i) solid stress depends on both cancer cells and their microenvironment; (ii) solid stress increases with tumour size; and (iii) mechanical confinement by the surrounding tissue significantly contributes to intratumoural solid stress. Further study of the genesis and consequences of solid stress, facilitated by the engineering principles presented here, may lead to significant discoveries and new therapies.