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Shen, Shiqian

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Shen

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Shiqian

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Shen, Shiqian

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2017 - 20182

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Author's Publications: search.filters.isAuthorOfPublication.7ec74e11-f645-4401-9323-36e4477dcc63

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    Gut Microbiota is critical for the induction of chemotherapy-induced pain
    (2017) Shen, Shiqian; Lim, Grewo; You, Zerong; Ding, Weihua; Huang, Peigen; Ran, Chongzhao; Doheny, Jason; Caravan, Peter; Tate, Samuel; Hu, Kun; Kim, Hyangin; McCabe, Michael; Huang, Bo; Xie, Zhongcong; Kwon, Douglas; Chen, Lucy; Mao, Jianren
    Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that the gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechnical hyperalgesia was reduced in germ-free mice and in those mice pretreated with antibiotics. Restoration of the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.
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    Anaesthesia for chest wall reconstruction in a patient with Poland syndrome: CARE-compliant case report and literature review
    (BioMed Central, 2018) Gui, Lingli; Shen, Shiqian; Mei, Wei
    Background: Poland syndrome is a rare congenital disease, characterized by agenesis/hypoplasia of the pectoralis major muscle, usually associated with variable thoracic anomalies that needed chest wall reconstruction under general anesthesia. Anaesthetic management in Poland syndrome has scarcely been described. Case presentation: Here, we present our anaesthetic management of Nuss procedure for chest wall correction in a 5 years old patient with Poland syndrome. We also reviewed the reports of anaesthetic management of Poland syndrome by searching Pubmed, and summarize the perioperative procedures that may warrant a safe surgery. Conclusions: Examinations before surgery, intraoperative monitoring, choice of general anesthetics and pain management after surgery should all be contemplated.