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Sullivan, Jessica

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Sullivan

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Jessica

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Sullivan, Jessica

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2015 - 20162

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Author's Publications: search.filters.isAuthorOfPublication.80528d2e-d221-4ffa-817c-798581b4e7d1

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    The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy
    (Nature Publishing Group, 2015) Wang, Leo; Rao, Tirzah; Rowe, Robert; Nguyen, Phi; Sullivan, Jessica; Pearson, Daniel; Doulatov, Sergei; Wu, Linwei; Lindsley, Robert; Zhu, Hao; DeAngelo, Daniel; Daley, George; Wagers, Amy
    Mast cells are critical components of the innate immune system and important for host 48 defense, allergy, autoimmunity, tissue regeneration, and tumor progression.Dysregulated 49 mastcell development leads to systemic mastocytosis, a clinically variable but often 50 devastating family of hematologic disorders. Here we report that induced expression of 51 Lin28, a heterochronic gene and pluripotency factor implicated in driving a fetal 52 hematopoietic program, caused mast cell accumulation in adult mice in target organs such 53 as the skin and peritoneal cavity. In vitro assays revealed a skewing of myeloid 54 commitment in LIN28B-­‐expressing hematopoietic progenitors, with increased levels of 55 LIN28B in common myeloid and basophil-­‐mast cell progenitors altering gene expression 56 patterns to favor cell fate choices that enhanced mast cell specification. In addition, 57 LIN28B-­‐induced mast cells appeared phenotypically and functionally immature, and in 58 vitro assays suggested a slowing of mast cell terminal differentiation in the context of 59 LIN28B upregulation. Finally, interrogation of human mast cell leukemia samples revealed 60 upregulation of LIN28B in abnormal mast cells from patients with systemic mastocytosis 61 (SM). This work identifies Lin28 as a novel regulator of innate immune function and a new 62 protein of interest in mast cell disease.
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    Learning Mathematics in a Visuo-Spatial Format: A Randomized, Controlled Trial of Mental Abacus Instruction
    (Center for Open Science, 2016-09-08) Barner, David; Alvarez, George; Sullivan, Jessica; Brooks, Neon Blue; Srinivasan, Mahesh; Frank, Michael C.; srinivasan
    Mental abacus (MA) is a technique of performing fast, accurate arithmetic using a mental image of an abacus; experts exhibit astonishing calculation abilities. Over 3 years, 204 elementary school students (age range at outset: 5-7 years old) participated in a randomized, controlled trial to test whether MA expertise (a) can be acquired in standard classroom settings, (b) improves students' mathematical abilities (beyond standard math curricula), and (c) is related to changes in basic cognitive capacities like working memory. MA students outperformed controls on arithmetic tasks, suggesting that MA expertise can be achieved by children in standard classrooms. MA training did not alter basic cognitive abilities; instead, differences in spatial working memory at the beginning of the study mediated MA learning. We conclude that MA expertise can be achieved by many children in standard classrooms and results from efficient use of pre-existing abilities.