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Yalak, Garif

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Yalak

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Garif

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Yalak, Garif

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2014 - 20152

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Author's Publications: search.filters.isAuthorOfPublication.888937d4-6645-47cf-9182-99ebfb7435fc

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Now showing 1 - 2 of 2
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    Ecto-protein kinases and phosphatases: an emerging field for translational medicine
    (BioMed Central, 2014) Yalak, Garif; Ehrlich, Yigal H; Olsen, Bjorn
    Progress in translational research has led to effective new treatments of a large number of diseases. Despite this progress, diseases including cancer and cardiovascular disorders still are at the top in death statistics and disorders such as osteoporosis and osteoarthritis represent an increasing disease burden in the aging population. Novel strategies in research are needed more than ever to overcome such diseases. The growing field of extracellular protein phosphorylation provides excellent opportunities to make major discoveries of disease mechanisms that can lead to novel therapies. Reversible phosphorylation/dephosphorylation of sites in the extracellular domains of matrix, cell-surface and trans-membrane proteins is emerging as a critical regulatory mechanism in health and disease. Moreover, a new concept is emerging from studies of extracellular protein phosphorylation: in cells where ATP is stored within secretory vesicles and released by exocytosis upon cell-stimulation, phosphorylation of extracellular proteins can operate as a messenger operating uniquely in signaling pathways responsible for long-term cellular adaptation. Here, we highlight new concepts that arise from this research, and discuss translation of the findings into clinical applications such as development of diagnostic disease markers and next-generation drugs.
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    Proteomic database mining opens up avenues utilizing extracellular protein phosphorylation for novel therapeutic applications
    (BioMed Central, 2015) Yalak, Garif; Olsen, Bjorn
    Summary Recent advances in extracellular signaling suggest that extracellular protein phosphorylation is a regulatory mechanism outside the cell. The list of reported active extracellular protein kinases and phosphatases is growing, and phosphorylation of an increasing number of extracellular matrix molecules and extracellular domains of trans-membrane proteins is being documented. Here, we use public proteomic databases, collagens – the major components of the extracellular matrix, extracellular signaling molecules and proteolytic enzymes as examples to assess what the roles of extracellular protein phosphorylation may be in health and disease. We propose that novel tools be developed to help assess the role of extracellular protein phosphorylation and translate the findings for biomedical applications. Furthermore, we suggest that the phosphorylation state of extracellular matrix components as well as the presence of extracellular kinases be taken into account when designing translational medical applications. Electronic supplementary material The online version of this article (doi:10.1186/s12967-015-0482-4) contains supplementary material, which is available to authorized users.