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Von Oettingen, Julia Elisabeth

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Von Oettingen

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Julia Elisabeth

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Von Oettingen, Julia Elisabeth

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Author's Publications: search.filters.isAuthorOfPublication.8ba82d54-bf6e-43dd-bae4-ecd0f8b3e36bAuthor: search.filters.author.Lockman, ShahinAuthor: search.filters.author.Hughes, MichaelAuthor: search.filters.author.Essex, MaxAuthor: search.filters.author.Fawzi, WafaieSubject: search.filters.subject.maternal vitamin DSubject: search.filters.subject.growthSubject: search.filters.subject.mortalitySubject: search.filters.subject.morbidity

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    Vitamin D Insufficiency in HIV-infected Pregnant Women Receiving Antiretroviral Therapy is Not Associated With Morbidity, Mortality or Growth Impairment in Their Uninfected Infants in Botswana

    (Ovid Technologies (Wolters Kluwer Health), 2014) Powis, Kathleen; Lockman, Shahin; Smeaton, Laura; Hughes, Michael; Fawzi, Wafaie; Ogwu, Anthony; Moyo, Sikhulile; van Widenfelt, Erik; Von Oettingen, Julia Elisabeth; Makhema, Joseph; Essex, Max; Shapiro, Roger

    Background

    Low maternal 25(OH)D (vitamin D) values have been associated with higher mortality and impaired growth among HIV-exposed uninfected (HEU) infants of antiretroviral (ART)-naïve women. These associations have not been studied among HEU infants of women receiving ART.

    Methods

    We performed a nested case-control study in the Botswana Mma Bana Study, a study providing ART to women during pregnancy and breastfeeding. Median maternal vitamin D values, and the proportion with maternal vitamin D insufficiency, were compared between women whose HEU infants experienced morbidity/mortality during 24 months of follow-up and women with non-hospitalized HEU infants. Growth faltering was assessed for never hospitalized infants attending the 24-month-of-life visit. Multivariate logistic regression models determined associations between maternal vitamin D insufficiency and infant morbidity/mortality and growth faltering.

    Results

    Delivery plasma was available and vitamin D levels assayable from 119 (86%) of 139 cases and 233 (84%) of 278 controls, and did not differ significantly between cases and controls (median 36.7 ng/mL; IQR 29.1- 44.7 vs. 37.1 ng/mL; IQR 30.0 - 47.2; p = 0.32). Vitamin D insufficiency (< 32 ng/mL) was recorded among 112 (31.8%) of 352 women at delivery and occurred most frequently among women delivering in winter. Multivariate logistic regression models adjusted for maternal HIV disease progression did not show associations between maternal vitamin D insufficiency at delivery and child morbidity/mortality, or 24-month-of-life growth faltering.

    Conclusions

    Vitamin D insufficiency was common among ART treated pregnant women in Botswana, but was not associated with morbidity, mortality or growth impairment in their HIV-uninfected children.