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Ximerakis, Methodios

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Ximerakis

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Methodios

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Ximerakis, Methodios

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    Single-cell transcriptomic profiling of the aging mouse brain
    (Springer Science and Business Media LLC, 2019-09-24) Ximerakis, Methodios; Lipnick, Scott; Innes, Brendan; Simmons, Sean; Adiconis, Xian; Dionne, Danielle; Mayweather, Brittany; Nguyen, Lan; Ozek, Ceren; Butty, Vincent; Isserlin, Ruth; Buchanan, Sean; Levine, Stuart; Regev, Aviv; Bader, Gary; Levin, Joshua; Rubin, Lee
    The mammalian brain is complex, with multiple cell types performing a variety of diverse functions, but exactly how each cell type is affected in aging remains largely unknown. Here we performed a single-cell transcriptomic analysis of young and old mouse brains. We provide comprehensive datasets of aging-related genes, pathways and ligand–receptor interactions in nearly all brain cell types. Our analysis identified gene signatures that vary in a coordinated manner across cell types and gene sets that are regulated in a cell-type specific manner, even at times in opposite directions. These data reveal that aging, rather than inducing a universal program, drives a distinct transcriptional course in each cell population, and they highlight key molecular processes, including ribosome biogenesis, underlying brain aging. Overall, these large-scale datasets (accessible online at https://portals.broadinstitute.org/single_cell/study/aging-mouse-brain) provide a resource for the neuroscience community that will facilitate additional discoveries directed towards understanding and modifying the aging process. believe that this large-scale dataset, which is publicly accessible online (aging-mouse-brain), will facilitate additional discoveries directed towards understanding and modifying the aging process.