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Kotliar, Dylan

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Kotliar

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Dylan

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Kotliar, Dylan

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2015 - 20182

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Author's Publications: search.filters.isAuthorOfPublication.8e2f7127-2aba-4c4d-98b2-8067ec5687dc

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    Medical education in the United States: do residents feel prepared?
    (Bohn Stafleu van Loghum, 2015) Chen, Chen Amy; Kotliar, Dylan; Drolet, Brian C.
    Background: Medical schools face a growing challenge in providing a comprehensive educational experience. Students must graduate with not only the medical knowledge but also the requisite skills to care for patients and serve as physicians-in-training. Objective: To assess whether residents felt prepared by their medical school training. Method We developed a questionnaire to assess resident attitudes towards various aspects of their medical school training and electronically distributed it among 107 United States training institutions. Results: A total of 2287 residents responded. Overall, a majority (53.8 %) agreed that ‘medical school prepared me well to be a resident.’ Most residents felt very well or mostly prepared in medical knowledge and clinical skills such as collecting a history (92.3 %), presenting a physical exam (86.1 %), or pathophysiology (81.6 %), but not for applied medical and psychosocial practices including end-of-life care (41.7 %), dealing with a patient death (46.3 %), and considering cost-effective care (28.7 %). Additionally, many residents reported feeling underprepared for time and fatigue management, debt, and medical-legal issues. Conclusions: Medical school graduates generally feel well prepared for residency. However, they may be less prepared to face important psychosocial, cultural and professional issues. Ultimately, a greater emphasis on skills and psychosocial experience may yield graduates who feel better prepared for today's residency challenges.
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    Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever
    (Nature Publishing Group UK, 2018) Boisen, Matthew L.; Hartnett, Jessica N.; Shaffer, Jeffrey G.; Goba, Augustine; Momoh, Mambu; Sandi, John Demby; Fullah, Mohamed; Nelson, Diana K. S.; Bush, Duane J.; Rowland, Megan M.; Heinrich, Megan L.; Koval, Anatoliy P.; Cross, Robert W.; Barnes, Kayle; Lachenauer, Anna E.; Lin, Aaron; Nekoui, Mahan; Kotliar, Dylan; Winnicki, Sarah; Siddle, Katherine; Gbakie, Michael; Fonnie, Mbalu; Koroma, Veronica J.; Kanneh, Lansana; Kulakosky, Peter C.; Hastie, Kathryn M.; Wilson, Russell B.; Andersen, Kristian G.; Folarin, Onikepe O.; Happi, Christian T.; Sabeti, Pardis; Geisbert, Thomas W.; Saphire, Erica Ollmann; Khan, S. Humarr; Grant, Donald S.; Schieffelin, John S.; Branco, Luis M.; Garry, Robert F.
    Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a patient’s clinical presentation. The field performance of recombinant antigen-based Lassa fever immunoassays was compared to that of quantitative polymerase chain assays (qPCRs) using samples from subjects meeting the case definition of Lassa fever presenting to Kenema Government Hospital in Sierra Leone. The recombinant Lassa virus (ReLASV) enzyme-linked immunosorbant assay (ELISA) for detection of viral antigen in blood performed with 95% sensitivity and 97% specificity using a diagnostic standard that combined results of the immunoassays and qPCR. The ReLASV rapid diagnostic test (RDT), a lateral flow immunoassay based on paired monoclonal antibodies to the Josiah strain of LASV (lineage IV), performed with 90% sensitivity and 100% specificity. ReLASV immunoassays performed better than the most robust qPCR currently available, which had 82% sensitivity and 95% specificity. The performance characteristics of recombinant antigen-based Lassa virus immunoassays indicate that they can aid in the diagnosis of LASV Infection and inform the clinical management of Lassa fever patients.