Person: Yu, Xiaocong
Loading...
Email Address
AA Acceptance Date
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
Yu
First Name
Xiaocong
Name
Yu, Xiaocong
2 results
Search Results
Now showing 1 - 2 of 2
Publication Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease(2013) Yu, Xiaocong; Li, Zihai; Zhou, Zhenxian; Kilby, J Michael; Jiang, WeiAlthough T cells are the primary and most-studied targets of the Human Immunodeficiency Virus (HIV), B cells, especially memory B lymphocytes, are also chronically depleted in the course of HIV disease. Although the lack of CD4+ T cell help may explain these deficiencies, intrinsic defects in B lymphocytes appear to contribute to B cell depletion and reduced antibody (Ab) production in the setting of HIV, especially of some antigens eliciting T cell-independent responses. The gut mucosal barrier is disrupted in HIV disease, resulting in increased systemic exposure to microbial products such as Toll-Like Receptor (TLR) agonists. The association of enhanced systemic levels of TLR agonists and B cell dysfunction in HIV disease is not understood. This review discusses the potential role of microbial TLR agonists in the B cell depletion, enhanced autoantibody production and impaired responses to vaccination observed in HIV-infected hosts. Increased microbial translocation in HIV infection may drive B cells to produce autoantibodies and increase susceptibilities of B cells to apoptosis through activation-induced cell death. Determining the mechanisms of B cell perturbations in HIV disease will inform the design of novel strategies of improve immune responses to vaccines, reduce opportunistic infections and slow disease progression.Publication Impact of IgA Constant Domain on HIV-1 Neutralizing Function of Monoclonal Antibody F425-A1g8(BioMed Central, 2012) Yu, Xiaocong; Duval, M; Lewis, C; Cavacini, Lisa Ann