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Foster, Rosemary

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Foster

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Rosemary

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Foster, Rosemary
Author's Publications: search.filters.isAuthorOfPublication.93996d53-863b-4636-b4fb-e8d3656762ea

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    Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau
    (Impact Journals LLC, 2018) Starbuck, Kristen; Al-Alem, Linah; Eavarone, David A.; Hernandez, Silvia Fatima; Bellio, Chiara; Prendergast, Jillian M.; Stein, Jenna; Dransfield, Daniel T.; Zarrella, Bianca; Growdon, Whitfield B.; Behrens, Jeff; Foster, Rosemary; Rueda, Bo
    Recurrent ovarian cancer (OvCa) is thought to result in part from the inability to eliminate rare quiescent cancer stem cells (CSCs) that survive cytotoxic chemotherapy and drive tumor resurgence. The Sialyl-Thomsen-nouveau antigen (STn) is a carbohydrate moiety present on protein markers of CSCs in pancreatic, colon, and gastric malignancies. We have demonstrated that human OvCa cell lines contain varying levels of cells that independently express either STn or the ovarian CSC marker CD133. Here we determine co-expression of STn and CD133 in a subset of human OvCa cell lines. Analyses of colony and sphere forming capacity and of response to standard-of-care cytotoxic therapy suggest a subset of OvCa STn+ cells display some CSC features. The effect of the anti-STn antibody-drug conjugates (ADCs) S3F-CL-MMAE and 2G12-2B2-CL-MMAE on OvCa cell viability in vitro and in vivo was also assessed. Treatment with S3F-CL-MMAE reduced the viability of two of three OvCa cell lines in vitro and exposure to either S3F-CL-MMAE or 2G12-2B2-CL-MMAE reduced OVCAR3-derived xenograft volume in vivo, depleting STn+ tumor cells. In summary, STn+ cells demonstrate some stem-like properties and specific therapeutic targeting of STn in ovarian tumors may be an effective clinical strategy to eliminate both STn+ CSC and STn+ non-CSC populations.
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    MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma
    (BioMed Central, 2018) Cardozo, Eden R.; Foster, Rosemary; Karmon, Anatte E.; Lee, Amy E.; Gatune, Leah W.; Rueda, Bo; Styer, Aaron
    Background: MicroRNAs (MiR) may promote fibroid development via altered expression of genes involved in cell proliferation and ECM formation, and evidence supports aberrant expression of MicroRNA (MiR) 21a-5p in fibroids. The purpose of this study was to investigate the functional significance of MiR 21a-5p overexpression in the pathobiology of leiomyomata (fibroids). Methods: A basic science experimental design using immortalized fibroid and myometrial cell lines derived from patient-matched specimens was used. Stable overexpression of MiR-21a-5p in an immortalized fibroid and patient matched myometrial cell line was achieved through lentiviral vector infection. Main outcome measures were MiR-21-5p overexpression, target gene and protein expression, collagen (COL1A1) production, cell proliferation, cell migration, and cell cycle stages of fibroid and myometrial immortalized cell lines. Results: MiR-21a-5p was overexpressed to similar levels in fibroid and myometrial cell lines after lentiviral infection. Increased expression of miR-21 resulted in increased gene and protein expression of TGF-β3 in both fibroid and myometrial cells. Changes in expression of the ECM genes Fibronectin, Collagen 1A1, CTGF, Versican and DPT were seen in both fibroid and myometrial cells. Changes were also seen in Matrix Metalloproteinase (MMP) related genes including MMP 2, MMP 9, MMP 11 and Serpine 1 in both fibroid and myometrial cells. MiR-21 upregulation resulted in increased proliferation and migration in fibroid cells compared to myometrial cells. Conclusions: MiR-21a-5p overexpression results in changes in the expression of ECM mediators in both fibroid and myometrial cells, and increased cell proliferation in fibroid cells. These finding suggest a potential functional role of MiR-21a-5p in the development of uterine fibroids and warrant further investigation. Electronic supplementary material The online version of this article (10.1186/s12958-018-0364-8) contains supplementary material, which is available to authorized users.
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    Inhibition of Notch Signaling in Combination with Paclitaxel Reduces Platinum-Resistant Ovarian Tumor Growth
    (Frontiers Media S.A., 2014) Groeneweg, Jolijn W.; DiGloria, Celeste M.; Yuan, Jing; Richardson, William S.; Growdon, Whitfield B.; Sathyanarayanan, Sriram; Foster, Rosemary; Rueda, Bo
    Introduction: Ovarian cancer (OvCa) is the most lethal gynecologic malignancy in the United States because of chemoresistant recurrent disease. Our objective was to investigate the efficacy of inhibiting the Notch pathway with a γ-secretase inhibitor (GSI) in an OvCa patient-derived xenograft model as a single agent therapy and in combination with standard chemotherapy. Methods: Immunocompromised mice bearing xenografts derived from clinically platinum-sensitive human ovarian serous carcinomas were treated with vehicle, GSI (MRK-003) alone, paclitaxel and carboplatin (P/C) alone, or the combination of GSI and P/C. Mice bearing platinum-resistant xenografts were given GSI with or without paclitaxel. Gene transcript levels of the Notch pathway target Hes1 were analyzed using RT-PCR. Notch1 and Notch3 protein levels were evaluated. The Wilcoxon rank-sum test was used to assess significance between the different treatment groups. Results: Expression of Notch1 and 3 was variable. GSI alone decreased tumor growth in two of three platinum-sensitive ovarian tumors (p < 0.05), as well as in one of three platinum-sensitive tumors (p = 0.04). The combination of GSI and paclitaxel was significantly more effective than GSI alone and paclitaxel alone in all platinum-resistant ovarian tumors (all p < 0.05). The addition of GSI did not alter the effect of P/C in platinum-sensitive tumors. Interestingly, although the response of each tumor to chronic GSI exposure did not correlate with its endogenous level of Notch expression, GSI did negatively affect Notch signaling in an acute setting. Conclusion: Inhibiting the Notch signaling cascade with a GSI reduces primary human xenograft growth in vivo. GSI synergized with conventional cytotoxic chemotherapy only in the platinum-resistant OvCa models with single agent paclitaxel. These findings suggest inhibition of the Notch pathway in concert with taxane therapy may hold promise for treatment of platinum-resistant OvCa.
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    Notch signaling in serous ovarian cancer
    (BioMed Central, 2014) Groeneweg, Jolijn W; Foster, Rosemary; Growdon, Whitfield B; Verheijen, René HM; Rueda, Bo
    Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors. While cytoreductive surgery followed by platinum based chemotherapy are initially effective, ovarian tumors have a high propensity to recur highlighting the distinct need for novel therapeutics to improve outcomes for affected women. The Notch signaling pathway plays an established role in embryologic development and deregulation of this signaling cascade has been linked to many cancers. Recent genomic profiling of serous ovarian carcinoma revealed that Notch pathway alterations are among the most prevalent detected genomic changes. A growing body of scientific literature has confirmed heightened Notch signaling activity in ovarian carcinoma, and has utilized in vitro and in vivo models to suggest that targeting this pathway with gamma secretase inhibitors (GSIs) leads to anti-tumor effects. While it is currently unknown if Notch pathway inhibition can offer clinical benefit to women with ovarian cancer, several GSIs are currently in phase I and II trials across many disease sites including ovary. This review will provide background on Notch pathway function and will focus on the pre-clinical literature that links altered Notch signaling to ovarian cancer progression.
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    31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016
    (BioMed Central, 2016) Ager, Casey; Reilley, Matthew; Nicholas, Courtney; Bartkowiak, Todd; Jaiswal, Ashvin; Curran, Michael; Albershardt, Tina C.; Bajaj, Anshika; Archer, Jacob F.; Reeves, Rebecca S.; Ngo, Lisa Y.; Berglund, Peter; ter Meulen, Jan; Denis, Caroline; Ghadially, Hormas; Arnoux, Thomas; Chanuc, Fabien; Fuseri, Nicolas; Wilkinson, Robert W.; Wagtmann, Nicolai; Morel, Yannis; Andre, Pascale; Atkins, Michael B.; Carlino, Matteo S.; Ribas, Antoni; Thompson, John A.; Choueiri, Toni; Hodi, F. Stephen; Hwu, Wen-Jen; McDermott, David; Atkinson, Victoria; Cebon, Jonathan S.; Fitzharris, Bernie; Jameson, Michael B.; McNeil, Catriona; Hill, Andrew G.; Mangin, Eric; Ahamadi, Malidi; van Vugt, Marianne; van Zutphen, Mariëlle; Ibrahim, Nageatte; Long, Georgina V.; Gartrell, Robyn; Blake, Zoe; Simoes, Ines; Fu, Yichun; Saito, Takuro; Qian, Yingzhi; Lu, Yan; Saenger, Yvonne M.; Budhu, Sadna; De Henau, Olivier; Zappasodi, Roberta; Schlunegger, Kyle; Freimark, Bruce; Hutchins, Jeff; Barker, Christopher A.; Wolchok, Jedd D.; Merghoub, Taha; Burova, Elena; Allbritton, Omaira; Hong, Peter; Dai, Jie; Pei, Jerry; Liu, Matt; Kantrowitz, Joel; Lai, Venus; Poueymirou, William; MacDonald, Douglas; Ioffe, Ella; Mohrs, Markus; Olson, William; Thurston, Gavin; Capasso, Cristian; Frascaro, Federica; Carpi, Sara; Tähtinen, Siri; Feola, Sara; Fusciello, Manlio; Peltonen, Karita; Martins, Beatriz; Sjöberg, Madeleine; Pesonen, Sari; Ranki, Tuuli; Kyruk, Lukasz; Ylösmäki, Erkko; Cerullo, Vincenzo; Cerignoli, Fabio; Xi, Biao; Guenther, Garret; Yu, Naichen; Muir, Lincoln; Zhao, Leyna; Abassi, Yama; Cervera-Carrascón, Víctor; Siurala, Mikko; Santos, João; Havunen, Riikka; Parviainen, Suvi; Hemminki, Akseli; Dalgleish, Angus; Mudan, Satvinder; DeBenedette, Mark; Plachco, Ana; Gamble, Alicia; Grogan, Elizabeth W.; Krisko, John; Tcherepanova, Irina; Nicolette, Charles; Dhupkar, Pooja; Yu, Ling; Kleinerman, Eugenie S.; Gordon, Nancy; Grenga, Italia; Lepone, Lauren; Gameiro, Sofia; Knudson, Karin M.; Fantini, Massimo; Tsang, Kwong; Hodge, James; Donahue, Renee; Schlom, Jeffrey; Evans, Elizabeth; Bussler, Holm; Mallow, Crystal; Reilly, Christine; Torno, Sebold; Scrivens, Maria; Foster, Cathie; Howell, Alan; Balch, Leslie; Knapp, Alyssa; Leonard, John E.; Paris, Mark; Fisher, Terry; Hu-Lieskovan, Siwen; Smith, Ernest; Zauderer, Maurice; Fogler, William; Franklin, Marilyn; Thayer, Matt; Saims, Dan; Magnani, John L.; Gong, Jian; Gray, Michael; Fromm, George; de Silva, Suresh; Giffin, Louise; Xu, Xin; Rose, Jason; Schreiber, Taylor H.; Gameiro, Sofia R.; Clavijo, Paul E.; Allen, Clint T.; Hodge, James W.; Tsang, Kwong Y.; Grogan, Jane; Manieri, Nicholas; Chiang, Eugene; Caplazi, Patrick; Yadav, Mahesh; Hagner, Patrick; Chiu, Hsiling; Waldman, Michelle; Klippel, Anke; Thakurta, Anjan; Pourdehnad, Michael; Gandhi, Anita; Henrich, Ian; Quick, Laura; Young, Rob; Chou, Margaret; Hotson, Andrew; Willingham, Stephen; Ho, Po; Choy, Carmen; Laport, Ginna; McCaffery, Ian; Miller, Richard; Tipton, Kimberly A.; Wong, Kenneth R.; Singson, Victoria; Wong, Chihunt; Chan, Chanty; Huang, Yuanhiu; Liu, Shouchun; Richardson, Jennifer H.; Kavanaugh, W. Michael; West, James; Irving, Bryan A.; Jaini, Ritika; Loya, Matthew; Eng, Charis; Johnson, Melissa L.; Adjei, Alex A.; Opyrchal, Mateusz; Ramalingam, Suresh; Janne, Pasi A.; Dominguez, George; Gabrilovich, Dmitry; de Leon, Laura; Hasapidis, Jeannette; Diede, Scott J.; Ordentlich, Peter; Cruickshank, Scott; Meyers, Michael L.; Hellmann, Matthew D.; Kalinski, Pawel; Zureikat, Amer; Edwards, Robert; Muthuswamy, Ravi; Obermajer, Nataša; Urban, Julie; Butterfield, Lisa H.; Gooding, William; Zeh, Herbert; Bartlett, David; Zubkova, Olga; Agapova, Larissa; Kapralova, Marina; Krasovskaia, Liudmila; Ovsepyan, Armen; Lykov, Maxim; Eremeev, Artem; Bokovanov, Vladimir; Grigoryeva, Olga; Karpov, Andrey; Ruchko, Sergey; Shuster, Alexandr; Khalil, Danny N.; Campesato, Luis Felipe; Li, Yanyun; Lazorchak, Adam S.; Patterson, Troy D.; Ding, Yueyun; Sasikumar, Pottayil; Sudarshan, Naremaddepalli; Gowda, Nagaraj; Ramachandra, Raghuveer; Samiulla, Dodheri; Giri, Sanjeev; Eswarappa, Rajesh; Ramachandra, Murali; Tuck, David; Wyant, Timothy; Leshem, Jasmin; Liu, Xiu-fen; Bera, Tapan; Terabe, Masaki; Bossenmaier, Birgit; Niederfellner, Gerhard; Reiter, Yoram; Pastan, Ira; Xia, Leiming; Xia, Yang; Hu, Yangyang; Wang, Yi; Bao, Yangyi; Dai, Fu; Huang, Shiang; Hurt, Elaine; Hollingsworth, Robert E.; Lum, Lawrence G.; Chang, Alfred E.; Wicha, Max S.; Li, Qiao; Mace, Thomas; Makhijani, Neil; Talbert, Erin; Young, Gregory; Guttridge, Denis; Conwell, Darwin; Lesinski, Gregory B.; Gonzales, Rodney JM Macedo; Huffman, Austin P.; Wang, Ximi K.; Reshef, Ran; MacKinnon, Andy; Chen, Jason; Gross, Matt; Marguier, Gisele; Shwonek, Peter; Sotirovska, Natalija; Steggerda, Susanne; Parlati, Francesco; Makkouk, Amani; Bennett, Mark K.; Emberley, Ethan; Huang, Tony; Li, Weiqun; Neou, Silinda; Pan, Alison; Zhang, Jing; Zhang, Winter; Marshall, Netonia; Marron, Thomas U.; Agudo, Judith; Brown, Brian; Brody, Joshua; McQuinn, Christopher; Farren, Matthew; Komar, Hannah; Shakya, Reena; Ludwug, Thomas; Morillon, Y. Maurice; Hammond, Scott A.; Greiner, John W.; Nath, Pulak R.; Schwartz, Anthony L.; Maric, Dragan; Roberts, David D.; Naing, Aung; Papadopoulos, Kyriakos P.; Autio, Karen A.; Wong, Deborah J.; Patel, Manish; Falchook, Gerald; Pant, Shubham; Ott, Patrick A.; Whiteside, Melinda; Patnaik, Amita; Mumm, John; Janku, Filip; Chan, Ivan; Bauer, Todd; Colen, Rivka; VanVlasselaer, Peter; Brown, Gail L.; Tannir, Nizar M.; Oft, Martin; Infante, Jeffrey; Lipson, Evan; Gopal, Ajay; Neelapu, Sattva S.; Armand, Philippe; Spurgeon, Stephen; Leonard, John P.; Sanborn, Rachel E.; Melero, Ignacio; Gajewski, Thomas F.; Maurer, Matthew; Perna, Serena; Gutierrez, Andres A.; Clynes, Raphael; Mitra, Priyam; Suryawanshi, Satyendra; Gladstone, Douglas; Callahan, Margaret K.; Crooks, James; Brown, Sheila; Gauthier, Audrey; de Boisferon, Marc Hillairet; MacDonald, Andrew; Brunet, Laura Rosa; Rothwell, William T.; Bell, Peter; Wilson, James M.; Sato-Kaneko, Fumi; Yao, Shiyin; Zhang, Shannon S.; Carson, Dennis A.; Guiducci, Cristina; Coffman, Robert L.; Kitaura, Kazutaka; Matsutani, Takaji; Suzuki, Ryuji; Hayashi, Tomoko; Cohen, Ezra E. W.; Schaer, David; Li, Yanxia; Dobkin, Julie; Amatulli, Michael; Hall, Gerald; Doman, Thompson; Manro, Jason; Dorsey, Frank Charles; Sams, Lillian; Holmgaard, Rikke; Persaud, Krishnadatt; Ludwig, Dale; Surguladze, David; Kauh, John S.; Novosiadly, Ruslan; Kalos, Michael; Driscoll, Kyla; Pandha, Hardev; Ralph, Christy; Harrington, Kevin; Curti, Brendan; Akerley, Wallace; Gupta, Sumati; Melcher, Alan; Mansfield, David; Kaufman, David R.; Schmidt, Emmett; Grose, Mark; Davies, Bronwyn; Karpathy, Roberta; Shafren, Darren; Shamalov, Katerina; Cohen, Cyrille; Sharma, Naveen; Allison, James; Shekarian, Tala; Valsesia-Wittmann, Sandrine; Caux, Christophe; Marabelle, Aurelien; Slomovitz, Brian M.; Moore, Kathleen M.; Youssoufian, Hagop; Posner, Marshall; Tewary, Poonam; Brooks, Alan D.; Xu, Ya-Ming; Wijeratne, Kithsiri; Gunatilaka, Leslie A. A.; Sayers, Thomas J.; Vasilakos, John P.; Alston, Tesha; Dovedi, Simon; Elvecrog, James; Grigsby, Iwen; Herbst, Ronald; Johnson, Karen; Moeckly, Craig; Mullins, Stefanie; Siebenaler, Kristen; SternJohn, Julius; Tilahun, Ashenafi; Tomai, Mark A.; Vogel, Katharina; Vietsch, Eveline E.; Wellstein, Anton; Wythes, Martin; Crosignani, Stefano; Tumang, Joseph; Alekar, Shilpa; Bingham, Patrick; Cauwenberghs, Sandra; Chaplin, Jenny; Dalvie, Deepak; Denies, Sofie; De Maeseneire, Coraline; Feng, JunLi; Frederix, Kim; Greasley, Samantha; Guo, Jie; Hardwick, James; Kaiser, Stephen; Jessen, Katti; Kindt, Erick; Letellier, Marie-Claire; Li, Wenlin; Maegley, Karen; Marillier, Reece; Miller, Nichol; Murray, Brion; Pirson, Romain; Preillon, Julie; Rabolli, Virginie; Ray, Chad; Ryan, Kevin; Scales, Stephanie; Srirangam, Jay; Solowiej, Jim; Stewart, Al; Streiner, Nicole; Torti, Vince; Tsaparikos, Konstantinos; Zheng, Xianxian; Driessens, Gregory; Gomes, Bruno; Kraus, Manfred; Xu, Chunxiao; Zhang, Yanping; Kradjian, Giorgio; Qin, Guozhong; Qi, Jin; Xu, Xiaomei; Marelli, Bo; Yu, Huakui; Guzman, Wilson; Tighe, Rober; Salazar, Rachel; Lo, Kin-Ming; English, Jessie; Radvanyi, Laszlo; Lan, Yan; Postow, Michael; Senbabaoglu, Yasin; Gasmi, Billel; Zhong, Hong; Liu, Cailian; Hirschhorhn-Cymerman, Daniel; Zha, Yuanyuan; Malnassy, Gregory; Fulton, Noreen; Park, Jae-Hyun; Stock, Wendy; Nakamura, Yusuke; Liu, Hongtao; Ju, Xiaoming; Kosoff, Rachelle; Ramos, Kimberly; Coder, Brandon; Petit, Robert; Princiotta, Michael; Perry, Kyle; Zou, Jun; Arina, Ainhoa; Fernandez, Christian; Zheng, Wenxin; Beckett, Michael A.; Mauceri, Helena J.; Fu, Yang-Xin; Weichselbaum, Ralph R.; Lewis, Whitney; Han, Yanyan; Wu, Yeting; Yang, Chou; Huang, Jing; Wu, Dongyun; Li, Jin; Liang, Xiaoling; Zhou, Xiangjun; Hou, Jinlin; Hassan, Raffit; Jahan, Thierry; Antonia, Scott J.; Kindler, Hedy L.; Alley, Evan W.; Honarmand, Somayeh; Liu, Weiqun; Leong, Meredith L.; Whiting, Chan C.; Nair, Nitya; Enstrom, Amanda; Lemmens, Edward E.; Tsujikawa, Takahiro; Kumar, Sushil; Coussens, Lisa M.; Murphy, Aimee L.; Brockstedt, Dirk G.; Koch, Sven D.; Sebastian, Martin; Weiss, Christian; Früh, Martin; Pless, Miklos; Cathomas, Richard; Hilbe, Wolfgang; Pall, Georg; Wehler, Thomas; Alt, Jürgen; Bischoff, Helge; Geissler, Michael; Griesinger, Frank; Kollmeier, Jens; Papachristofilou, Alexandros; Doener, Fatma; Fotin-Mleczek, Mariola; Hipp, Madeleine; Hong, Henoch S.; Kallen, Karl-Josef; Klinkhardt, Ute; Stosnach, Claudia; Scheel, Birgit; Schroeder, Andreas; Seibel, Tobias; Gnad-Vogt, Ulrike; Zippelius, Alfred; Park, Ha-Ram; Ahn, Yong-Oon; Kim, Tae Min; Kim, Soyeon; Kim, Seulki; Lee, Yu Soo; Keam, Bhumsuk; Kim, Dong-Wan; Heo, Dae Seog; Pilon-Thomas, Shari; Weber, Amy; Morse, Jennifer; Kodumudi, Krithika; Liu, Hao; Mullinax, John; Sarnaik, Amod A.; Pike, Luke; Bang, Andrew; Balboni, Tracy; Taylor, Allison; Spektor, Alexander; Wilhite, Tyler; Krishnan, Monica; Cagney, Daniel; Alexander, Brian; Aizer, Ayal; Buchbinder, Elizabeth; Awad, Mark; Ghandi, Leena; Schoenfeld, Jonathan; Lessey-Morillon, Elizabeth; Ridnour, Lisa; Segal, Neil H.; Sharma, Manish; Le, Dung T.; Ferris, Robert L.; Zelenetz, Andrew D.; Levy, Ronald; Lossos, Izidore S.; Jacobson, Caron; Ramchandren, Radhakrishnan; Godwin, John; Colevas, A. Dimitrios; Meier, Roland; Krishnan, Suba; Gu, Xuemin; Neely, Jaclyn; Timmerman, John; Vanpouille-Box, Claire I.; Formenti, Silvia C.; Demaria, Sandra; Wennerberg, Erik; Mediero, Aranzazu; Cronstein, Bruce N.; Gustafson, Michael P.; DiCostanzo, AriCeli; Wheatley, Courtney; Kim, Chul-Ho; Bornschlegl, Svetlana; Gastineau, Dennis A.; Johnson, Bruce D.; Dietz, Allan B.; MacDonald, Cameron; Bucsek, Mark; Qiao, Guanxi; Hylander, Bonnie; Repasky, Elizabeth; Turbitt, William J.; Xu, Yitong; Mastro, Andrea; Rogers, Connie J.; Withers, Sita; Wang, Ziming; Khuat, Lam T.; Dunai, Cordelia; Blazar, Bruce R.; Longo, Dan; Rebhun, Robert; Grossenbacher, Steven K.; Monjazeb, Arta; Murphy, William J.; Rowlinson, Scott; Agnello, Giulia; Alters, Susan; Lowe, David; Scharping, Nicole; Menk, Ashley V.; Whetstone, Ryan; Zeng, Xue; Delgoffe, Greg M.; Santos, Patricia M.; Shi, Jian; Delgoffe, Greg; Nagasaka, Misako; Sukari, Ammar; Byrne-Steele, Miranda; Pan, Wenjing; Hou, Xiaohong; Brown, Brittany; Eisenhower, Mary; Han, Jian; Collins, Natalie; Manguso, Robert; Pope, Hans; Shrestha, Yashaswi; Boehm, Jesse; Haining, W. Nicholas; Cron, Kyle R.; Sivan, Ayelet; Aquino-Michaels, Keston; Orecchioni, Marco; Bedognetti, Davide; Hendrickx, Wouter; Fuoco, Claudia; Spada, Filomena; Sgarrella, Francesco; Cesareni, Gianni; Marincola, Francesco; Kostarelos, Kostas; Bianco, Alberto; Delogu, Lucia; Roelands, Jessica; Boughorbel, Sabri; Decock, Julie; Presnell, Scott; Wang, Ena; Marincola, Franco M.; Kuppen, Peter; Ceccarelli, Michele; Rinchai, Darawan; Chaussabel, Damien; Miller, Lance; Nguyen, Andrew; Sanborn, J. Zachary; Vaske, Charles; Rabizadeh, Shahrooz; Niazi, Kayvan; Benz, Steven; Patel, Shashank; Restifo, Nicholas; White, James; Angiuoli, Sam; Sausen, Mark; Jones, Sian; Sevdali, Maria; Simmons, John; Velculescu, Victor; Diaz, Luis; Zhang, Theresa; Sims, Jennifer S.; Barton, Sunjay M.; Kadenhe-Chiweshe, Angela; Dela Cruz, Filemon; Turk, Andrew T.; Mazzeo, Christopher F.; Kung, Andrew L.; Bruce, Jeffrey N.; Yamashiro, Darrell J.; Connolly, Eileen P.; Baird, Jason; Crittenden, Marka; Friedman, David; Xiao, Hong; Leidner, Rom; Bell, Bryan; Young, Kristina; Gough, Michael; Bian, Zhen; Kidder, Koby; Liu, Yuan; Curran, Emily; Chen, Xiufen; Corrales, Leticia P.; Kline, Justin; Aguilar, Ethan G.; Guerriero, Jennifer; Sotayo, Alaba; Ponichtera, Holly; Pourzia, Alexandra; Schad, Sara; Carrasco, Ruben; Lazo, Suzan; Bronson, Roderick; Letai, Anthony; Kornbluth, Richard S.; Gupta, Sachin; Termini, James; Guirado, Elizabeth; Stone, Geoffrey W.; Meyer, Christina; Helming, Laura; Wilson, Nicholas; Hofmeister, Robert; Neubert, Natalie J.; Tillé, Laure; Barras, David; Soneson, Charlotte; Baumgaertner, Petra; Rimoldi, Donata; Gfeller, David; Delorenzi, Mauro; Fuertes Marraco, Silvia A.; Speiser, Daniel E.; Abraham, Tara S.; Xiang, Bo; Magee, Michael S.; Waldman, Scott A.; Snook, Adam E.; Blogowski, Wojciech; Zuba-Surma, Ewa; Budkowska, Marta; Salata, Daria; Dolegowska, Barbara; Starzynska, Teresa; Chan, Leo; Somanchi, Srinivas; McCulley, Kelsey; Lee, Dean; Buettner, Nico; Shi, Feng; Myers, Paisley T.; Curbishley, Stuart; Penny, Sarah A.; Steadman, Lora; Millar, David; Speers, Ellen; Ruth, Nicola; Wong, Gabriel; Thimme, Robert; Adams, David; Cobbold, Mark; Thomas, Remy; Al-Muftah, Mariam; Wong, Michael KK; Morse, Michael; Clark, Joseph I.; Kaufman, Howard L.; Daniels, Gregory A.; Hua, Hong; Rao, Tharak; Dutcher, Janice P.; Kang, Kai; Saunthararajah, Yogen; Velcheti, Vamsidhar; Kumar, Vikas; Anwar, Firoz; Verma, Amita; Chheda, Zinal; Kohanbash, Gary; Sidney, John; Okada, Kaori; Shrivastav, Shruti; Carrera, Diego A.; Liu, Shuming; Jahan, Naznin; Mueller, Sabine; Pollack, Ian F.; Carcaboso, Angel M.; Sette, Alessandro; Hou, Yafei; Okada, Hideho; Field, Jessica J.; Zeng, Weiping; Shih, Vincent FS; Law, Che-Leung; Senter, Peter D.; Gardai, Shyra J.; Okeley, Nicole M.; Abelin, Jennifer G.; Saeed, Abu Z.; Malaker, Stacy A.; Shabanowitz, Jeffrey; Ward, Stephen T.; Hunt, Donald F.; Profusek, Pam; Wood, Laura; Shepard, Dale; Grivas, Petros; Kapp, Kerstin; Volz, Barbara; Oswald, Detlef; Wittig, Burghardt; Schmidt, Manuel; Sefrin, Julian P.; Hillringhaus, Lars; Lifke, Valeria; Lifke, Alexander; Skaletskaya, Anna; Ponte, Jose; Chittenden, Thomas; Setiady, Yulius; Sivado, Eva; Thomas, Vincent; El Alaoui, Meddy; Papot, Sébastien; Dumontet, Charles; Dyson, Mike; McCafferty, John; El Alaoui, Said; Bommareddy, Praveen K.; Zloza, Andrew; Kohlhapp, Frederick; Silk, Ann W.; Jhawar, Sachin; Paneque, Tomas; Newman, Jenna; Beltran, Pedro; Cao, Felicia; Hong, Bang-Xing; Rodriguez-Cruz, Tania; Song, Xiao-Tong; Gottschalk, Stephen; Calderon, Hugo; Illingworth, Sam; Brown, Alice; Fisher, Kerry; Seymour, Len; Champion, Brian; Eriksson, Emma; Wenthe, Jessica; Hellström, Ann-Charlotte; Paul-Wetterberg, Gabriella; Loskog, Angelica; Milenova, Ioanna; Ståhle, Magnus; Jarblad-Leja, Justyna; Ullenhag, Gustav; Dimberg, Anna; Moreno, Rafael; Alemany, Ramon; Goyal, Sharad; Silk, Ann; Mehnert, Janice; Gabrail, Nashat; Bryan, Jennifer; Medina, Daniel; Mitchell, Leah; Yagiz, Kader; Lopez, Fernando; Mendoza, Daniel; Munday, Anthony; Gruber, Harry; Jolly, Douglas; Fuhrmann, Steven; Radoja, Sasa; Tan, Wei; Pourchet, Aldo; Frey, Alan; Mohr, Ian; Mulvey, Matthew; Andtbacka, Robert H. I.; Ross, Merrick; Agarwala, Sanjiv; Grossmann, Kenneth; Taylor, Matthew; Vetto, John; Neves, Rogerio; Daud, Adil; Khong, Hung; Meek, Stephanie M.; Ungerleider, Richard; Welden, Scott; Tanaka, Maki; Williams, Matthew; Hallmeyer, Sigrun; Fox, Bernard; Feng, Zipei; Paustian, Christopher; Bifulco, Carlo; Zafar, Sadia; Hemminki, Otto; Bramante, Simona; Vassilev, Lotta; Wang, Hongjie; Lieber, Andre; Hemmi, Silvio; de Gruijl, Tanja; Kanerva, Anna; Ansari, Tameem; Sundararaman, Srividya; Roen, Diana; Lehmann, Paul; Bloom, Anja C.; Bender, Lewis H.; Walters, Ian B.; Berzofsky, Jay A.; Chapelin, Fanny; Ahrens, Eric T.; DeFalco, Jeff; Harbell, Michael; Manning-Bog, Amy; Scholz, Alexander; Zhang, Danhui; Baia, Gilson; Tan, Yann Chong; Sokolove, Jeremy; Kim, Dongkyoon; Williamson, Kevin; Chen, Xiaomu; Colrain, Jillian; Santo, Gregg Espiritu; Nguyen, Ngan; Volkmuth, Wayne; Greenberg, Norman; Robinson, William; Emerling, Daniel; Drake, Charles G.; Petrylak, Daniel P.; Antonarakis, Emmanuel S.; Kibel, Adam S.; Chang, Nancy N.; Vu, Tuyen; Campogan, Dwayne; Haynes, Heather; Trager, James B.; Sheikh, Nadeem A.; Quinn, David I.; Kirk, Peter; Addepalli, Murali; Chang, Thomas; Zhang, Ping; Konakova, Marina; Hagihara, Katsunobu; Pai, Steven; VanderVeen, Laurie; Obalapur, Palakshi; Kuo, Peiwen; Quach, Phi; Fong, Lawrence; Charych, Deborah H.; Zalevsky, Jonathan; Langowski, John L.; Kirksey, Yolanda; Nutakki, Ravi; Kolarkar, Shalini; Pena, Rhoneil; Hoch, Ute; Doberstein, Stephen K.; Cha, John; Mallon, Zach; Perez, Myra; McDaniel, Amanda; Anand, Snjezana; Uecker, Darrin; Nuccitelli, Richard; Wieckowski, Eva; Muthuswamy, Ravikumar; Ravindranathan, Roshni; Renrick, Ariana N.; Thounaojam, Menaka; Thomas, Portia; Pellom, Samuel; Shanker, Anil; Dudimah, Duafalia; Brooks, Alan; Su, Yu-Lin; Adamus, Tomasz; Zhang, Qifang; Nechaev, Sergey; Kortylewski, Marcin; Wei, Spencer; Anderson, Clark; Tang, Chad; Schoenhals, Jonathan; Tsouko, Efrosini; Heymach, John; de Groot, Patricia; Chang, Joe; Hess, Kenneth R.; Diab, Adi; Sharma, Padmanee; Hong, David; Welsh, James; Parsons, Andrea J.; Leleux, Jardin; Ascarateil, Stephane; Koziol, Marie Eve; Bai, Dina; Dai, Peihong; Wang, Weiyi; Yang, Ning; Shuman, Stewart; Deng, Liang; Dillon, Patrick; Petroni, Gina; Brenin, David; Bullock, Kim; Olson, Walter; Smolkin, Mark E.; Smith, Kelly; Nail, Carmel; Slingluff, Craig L.; Sharma, Meenu; Fa’ak, Faisal; Janssen, Louise; Khong, Hiep; Xiao, Zhilan; Hailemichael, Yared; Singh, Manisha; Vianden, Christina; Overwijk, Willem W.; Facciabene, Andrea; Stefano, Pierini; Chongyung, Fang; Rafail, Stavros; Nielsen, Michael; Vanderslice, Peter; Woodside, Darren G.; Market, Robert V.; Biediger, Ronald J.; Marathi, Upendra K.; Hollevoet, Kevin; Geukens, Nick; Declerck, Paul; Joly, Nathalie; McIntosh, Laura; Paramithiotis, Eustache; Rizell, Magnus; Sternby, Malin; Andersson, Bengt; Karlsson-Parra, Alex; Kuai, Rui; Ochyl, Lukasz; Schwendeman, Anna; Moon, James; Deng, Weiwen; Hudson, Thomas E.; Hanson, Bill; Rae, Chris S.; Burrill, Joel; Skoble, Justin; Katibah, George; deVries, Michele; Lauer, Peter; Dubensky, Thomas W.; Chen, Xin; Zhou, Li; Ren, Xiubao; Aggarwal, Charu; Mangrolia, Drishty; Cohen, Roger; Weinstein, Gregory; Morrow, Matthew; Bauml, Joshua; Kraynyak, Kim; Boyer, Jean; Yan, Jian; Lee, Jessica; Humeau, Laurent; Oyola, Sandra; Duff, Susan; Weiner, David; Yang, Zane; Bagarazzi, Mark; McNeel, Douglas G.; Eickhoff, Jens; Jeraj, Robert; Staab, Mary Jane; Straus, Jane; Rekoske, Brian; Liu, Glenn; Melssen, Marit; Grosh, William; Varhegyi, Nikole; Galeassi, Nadejda; Deacon, Donna H.; Gaughan, Elizabeth; Ghisoli, Maurizio; Barve, Minal; Mennel, Robert; Wallraven, Gladice; Manning, Luisa; Senzer, Neil; Nemunaitis, John; Ogasawara, Masahiro; Ota, Shuichi; Peace, Kaitlin M.; Hale, Diane F.; Vreeland, Timothy J.; Jackson, Doreen O.; Berry, John S.; Trappey, Alfred F.; Herbert, Garth S.; Clifton, Guy T.; Hardin, Mark O.; Toms, Anne; Qiao, Na; Litton, Jennifer; Peoples, George E.; Mittendorf, Elizabeth A.; Ghamsari, Lila; Flano, Emilio; Jacques, Judy; Liu, Biao; Havel, Jonathan; Makarov, Vladimir; Chan, Timothy A.; Flechtner, Jessica B.; Facciponte, John; Ugel, Stefano; De Sanctis, Francesco; Coukos, George; Paris, Sébastien; Pottier, Agnes; Levy, Laurent; Lu, Bo; Cappuccini, Federica; Pollock, Emily; Bryant, Richard; Hamdy, Freddie; Hill, Adrian; Redchenko, Irina; Sultan, Hussein; Kumai, Takumi; Fesenkova, Valentyna; Celis, Esteban; Fernando, Ingrid; Palena, Claudia; David, Justin M.; Gabitzsch, Elizabeth; Jones, Frank; Gulley, James L.; Herranz, Mireia Uribe; Wada, Hiroshi; Shimizu, Atsushi; Osada, Toshihiro; Fukaya, Satoshi; Sasaki, Eiji; Abolhalaj, Milad; Askmyr, David; Lundberg, Kristina; Albrekt, Ann-Sofie; Greiff, Lennart; Lindstedt, Malin; Flies, Dallas B.; Higuchi, Tomoe; Ornatowski, Wojciech; Harris, Jaryse; Adams, Sarah F.; Aguilera, Todd; Rafat, Marjan; Castellini, Laura; Shehade, Hussein; Kariolis, Mihalis; Jang, Dadi; vonEbyen, Rie; Graves, Edward; Ellies, Lesley; Rankin, Erinn; Koong, Albert; Giaccia, Amato; Ajina, Reham; Wang, Shangzi; Smith, Jill; Pierobon, Mariaelena; Jablonski, Sandra; Petricoin, Emanuel; Weiner, Louis M.; Sherry, Lorcan; Waller, John; Anderson, Mark; Bigley, Alison; Bernatchez, Chantale; Haymaker, Cara; Kluger, Harriet; Tetzlaff, Michael; Jackson, Natalie; Gergel, Ivan; Tagliaferri, Mary; Hwu, Patrick; Snzol, Mario; Hurwitz, Michael; Barberi, Theresa; Martin, Allison; Suresh, Rahul; Barakat, David; Harris-Bookman, Sarah; Drake, Charles; Friedman, Alan; Berkey, Sara; Downs-Canner, Stephanie; Edwards, Robert P.; Curiel, Tyler; Odunsi, Kunle; Bruno, Tullia C.; Moore, Brandon; Squalls, Olivia; Ebner, Peggy; Waugh, Katherine; Mitchell, John; Franklin, Wilbur; Merrick, Daniel; McCarter, Martin; Palmer, Brent; Kern, Jeffrey; Vignali, Dario; Slansky, Jill; Chan, Anissa S. H.; Qiu, Xiaohong; Fraser, Kathryn; Jonas, Adria; Ottoson, Nadine; Gordon, Keith; Kangas, Takashi O.; Leonardo, Steven; Ertelt, Kathleen; Walsh, Richard; Uhlik, Mark; Graff, Jeremy; Bose, Nandita; Gupta, Ravi; Mandloi, Nitin; Paul, Kiran; Patil, Ashwini; Sathian, Rekha; Mohan, Aparna; Manoharan, Malini; Chaudhuri, Amitabha; Chen, Yu; Lin, Jing; Ye, Yun-bin; Xu, Chun-wei; Chen, Gang; Guo, Zeng-qing; Komarov, Andrey; Chenchik, Alex; Makhanov, Michael; Frangou, Costa; Zheng, Yi; Coltharp, Carla; Unfricht, Darryn; Dilworth, Ryan; Fridman, Leticia; Liu, Linying; Rajopadhye, Milind; Miller, Peter; Concha-Benavente, Fernando; Bauman, Julie; Trivedi, Sumita; Srivastava, Raghvendra; Ohr, James; Heron, Dwight; Duvvuri, Uma; Kim, Seungwon; Topley, Heather; Mera, Toshi; Okubo, Yoshiaki; Vanamee, Eva; Foster, Rosemary; Faustman, Denise; Stack, Edward; Izaki, Daisuke; Beck, Kristen; Jia, Dan Tong; Armenta, Paul; White-Stern, Ashley; Marks, Douglas; Taback, Bret; Horst, Basil; Glickman, Laura Hix; Kanne, David B.; Gauthier, Kelsey S.; Desbien, Anthony L.; Francica, Brian; Leong, Justin L.; Sung, Leonard; Metchette, Ken; Kasibhatla, Shailaja; Pferdekamper, Anne Marie; Zheng, Lianxing; Cho, Charles; Feng, Yan; McKenna, Jeffery M.; Tallarico, John; Bender, Steven; Ndubaku, Chudi; McWhirter, Sarah M.; Gugel, Elena Gonzalez; Bell, Charles J. M.; Munk, Adiel; Muniz, Luciana; Bhardwaj, Nina; Zhao, Fei; Evans, Kathy; Xiao, Christine; Holtzhausen, Alisha; Hanks, Brent A.; Scholler, Nathalie; Yin, Catherine; Van der Meijs, Pien; Prantner, Andrew M.; Krejsa, Cecile M.; Smith, Leia; Johnson, Brian; Branstetter, Daniel; Stein, Paul L.; Jaen, Juan C.; Tan, Joanne BL; Chen, Ada; Park, Timothy; Powers, Jay P.; Sexton, Holly; Xu, Guifen; Young, Steve W.; Schindler, Ulrike; Deng, Wentao; Klinke, David John; Komar, Hannah M.; Serpa, Gregory; Elnaggar, Omar; Hart, Philip; Schmidt, Carl; Dillhoff, Mary; Jin, Ming; Ostrowski, Michael C.; Koti, Madhuri; Au, Katrina; Peterson, Nichole; Truesdell, Peter; Reid-Schachter, Gillian; Graham, Charles; Craig, Andrew; Francis, Julie-Ann; Kotlan, Beatrix; Balatoni, Timea; Farkas, Emil; Toth, Laszlo; Ujhelyi, Mihaly; Savolt, Akos; Doleschall, Zoltan; Horvath, Szabolcs; Eles, Klara; Olasz, Judit; Csuka, Orsolya; Kasler, Miklos; Liszkay, Gabriella; Barnea, Eytan; Blakely, Collin; Flynn, Patrick; Goodman, Reid; Bueno, Raphael; Sugarbaker, David; Jablons, David; Broaddus, V. Courtney; West, Brian; Kunk, Paul R.; Obeid, Joseph M.; Winters, Kevin; Pramoonjago, Patcharin; Stelow, Edward B.; Bauer, Todd W.; Rahma, Osama E.; Lamble, Adam; Kosaka, Yoko; Huang, Fei; Saser, Kate A.; Adams, Homer; Tognon, Christina E.; Laderas, Ted; McWeeney, Shannon; Loriaux, Marc; Tyner, Jeffery W.; Druker, Brian J.; Lind, Evan F.; Liu, Zhuqing; Lu, Shanhong; Kane, Lawrence P.; Shayan, Gulidanna; Femel, Julia; Lane, Ryan; Booth, Jamie; Lund, Amanda W.; Rodriguez, Anthony; Engelhard, Victor H.; Metelli, Alessandra; Wu, Bill X.; Fugle, Caroline W.; Saleh, Rachidi; Sun, Shaoli; Wu, Jennifer; Liu, Bei; Li, Zihai; Morris, Zachary S.; Guy, Emily I.; Heinze, Clinton; Kler, Jasdeep; Gressett, Monica M.; Werner, Lauryn R.; Gillies, Stephen D.; Korman, Alan J.; Loibner, Hans; Hank, Jacquelyn A.; Rakhmilevich, Alexander L.; Harari, Paul M.; Sondel, Paul M.; Huelsmann, Erica; Broucek, Joseph; Brech, Dorothee; Straub, Tobias; Irmler, Martin; Beckers, Johannes; Buettner, Florian; Schaeffeler, Elke; Schwab, Matthias; Noessner, Elfriede; Wolfreys, Alison; Da Costa, Andre; Silva, John; Crosby, Andrea; Staelens, Ludovicus; Craggs, Graham; Cauvin, Annick; Mason, Sean; Paterson, Alison M.; Lake, Andrew C.; Armet, Caroline M.; O’Connor, Rachel W.; Hill, Jonathan A.; Normant, Emmanuel; Adam, Ammar; Biniszkiewicz, Detlev M.; Chappel, Scott C.; Palombella, Vito J.; Holland, Pamela M.; Becker, Annette; Leleti, Manmohan R.; Newcomb, Eric; Tan, Joanne B. L.; Rapisuwon, Suthee; Radfar, Arash; Gardner, Kellie; Gibney, Geoffrey; Atkins, Michael; Rennier, Keith R.; Crowder, Robert; Wang, Ping; Pachynski, Russell K.; Carrero, Rosa M. Santana; Rivas, Sarai; Beceren-Braun, Figen; Anthony, Scott; Schluns, Kimberly S.; Sawant, Deepali; Chikina, Maria; Yano, Hiroshi; Workman, Creg; Salerno, Elise; Mauldin, Ileana; Deacon, Donna; Shea, Sofia; Pinczewski, Joel; Gajewski, Thomas; Spranger, Stefani; Horton, Brendan; Suzuki, Akiko; Leland, Pamela; Joshi, Bharat H.; Puri, Raj K.; Sweis, Randy F.; Bao, Riyue; Luke, Jason; Theodoraki, Marie-Nicole; Mogundo, Frances-Mary; Won, Haejung; Moreira, Dayson; Gao, Chan; Zhao, Xingli; Duttagupta, Priyanka; Jones, Jeremy; D’Apuzzo, Massimo; Pal, Sumanta
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    Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours
    (Nature Pub. Group, 2015) Ince, Tan A.; Sousa, Aurea D.; Jones, Michelle A.; Harrell, J. Chuck; Agoston, Elin S.; Krohn, Marit; Selfors, Laura; Liu, Wenbin; Chen, Ken; Yong, Mao; Buchwald, Peter; Wang, Bin; Hale, Katherine S.; Cohick, Evan; Sergent, Petra; Witt, Abigail; Kozhekbaeva, Zhanna; Gao, Sizhen; Agoston, Agoston; Merritt, Melissa A.; Foster, Rosemary; Rueda, Bo; Crum, Christopher; Brugge, Joan; Mills, Gordon B.
    Currently available human tumour cell line panels consist of a small number of lines in each lineage that generally fail to retain the phenotype of the original patient tumour. Here we develop a cell culture medium that enables us to routinely establish cell lines from diverse subtypes of human ovarian cancers with >95% efficiency. Importantly, the 25 new ovarian tumour cell lines described here retain the genomic landscape, histopathology and molecular features of the original tumours. Furthermore, the molecular profile and drug response of these cell lines correlate with distinct groups of primary tumours with different outcomes. Thus, tumour cell lines derived using this methodology represent a significantly improved platform to study human tumour pathophysiology and response to therapy.
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    Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer
    (Impact Journals LLC, 2015) Gao, Yan; Foster, Rosemary; Yang, Xiaoqian; Feng, Yong; Shen, Jacson K.; Mankin, Henry; Hornicek, Francis; Amiji, Mansoor M.; Duan, Zhenfeng
    The clinical significance of Cluster of Differentiation 44 (CD44) remains controversial in human ovarian cancer. The aim of this study is to evaluate the clinical significance of CD44 expression by using a unique tissue microarray, and then to determine the biological functions of CD44 in ovarian cancer. In this study, a unique ovarian cancer tissue microarray (TMA) was constructed with paired primary, metastatic, and recurrent tumor tissues from 26 individual patients. CD44 expression in TMA was assessed by immunohistochemistry. Both the metastatic and recurrent ovarian cancer tissues expressed higher level of CD44 than the patient-matched primary tumor. A significant association has been shown between CD44 expression and both the disease free survival and overall survival. A strong increase of CD44 was found in the tumor recurrence of mouse model. Finally, when CD44 was knocked down, proliferation, migration/invasion activity, and spheroid formation were significantly suppressed, while drug sensitivity was enhanced. Thus, up-regulation of CD44 represents a crucial event in the development of metastasis, recurrence, and drug resistance to current treatments in ovarian cancer. Developing strategies to target CD44 may prevent metastasis, recurrence, and drug resistance in ovarian cancer.
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    Influence of a novel histone deacetylase inhibitor panobinostat (LBH589) on the growth of ovarian cancer
    (BioMed Central, 2016) Garrett, Leslie; Growdon, Whitfield B.; Rueda, Bo; Foster, Rosemary
    Background: Pre-clinical studies have demonstrated that natural and synthetic histone deacetylase (HDAC) inhibitors can impede the in vitro and in vivo growth of cell lines from a variety of gynecologic and other malignancies. We investigated the anti-tumor activity of panobinostat (LBH589) both in vitro and in vivo as either a single agent or in combination with conventional cytotoxic chemotherapy using patient-derived xenograft (PDX) models of primary serous ovarian tumors. Methods: The ovarian cancer cell lines OVCAR8, SKOV3 and their paclitaxel-resistant derivatives OVCAR8-TR and SKOV3-TR were treated with increasing doses of LBH589. The effect of LBH589 on cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Serially transplanted primary human high-grade serous ovarian adenocarcinoma tissue was utilized to generate xenografts in 6-week old female NOD/SCID mice. The mice were then randomized into one of 4 treatment groups: (1) vehicle control; (2) paclitaxel and carboplatin (P/C); (3) LBH589; or (4) P/C + LBH589. Mice were treated for 21 days and tumor volumes and mouse weights were obtained every 3 days. These experiments were performed in triplicate with three different patient derived tumors. Wilcoxan rank-sum testing was utilized to assess tumor volume differences. Results: In vitro treatment with LBH589 significantly reduced the viability of both taxol-sensitive and taxol-resistant ovarian cancer cell lines (p < 0.01). In vivo treatment with LBH589 alone appeared tumorstatic and reduced tumor growth when compared to vehicle treatment (p < 0.007) after 21 days. This single agent activity was confirmed in two additional experiments with other PDX tumors (p < 0.03, p < 0.05). A potential additive effect of LBH589 and P/C, manifested as enhanced tumor regression with the addition of LBH589 compared to vehicle (p < 0.02), in one of the three analyzed serous PDX models. Conclusions: Our findings suggest that pan-HDAC inhibition with panobinostat precludes the growth of ovarian cancer cell lines in vitro and PDXs in vivo. Added benefit of LBH589 to standard P/C therapy was observed in one of three PDX models suggesting improved response in a subset of serous ovarian cancers.