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Oribe, Naoya

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Oribe

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Naoya

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Oribe, Naoya
Author's Publications: search.filters.isAuthorOfPublication.95ea6311-07fa-43e9-a031-5089aef27f94

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    Clinical high risk and first episode schizophrenia: Auditory event-related potentials
    (Elsevier BV, 2015) Del Re, Elisabetta; Spencer, Kevin; Oribe, Naoya; Mesholam-Gately, Raquelle; Goldstein, Jill; Shenton, Martha; Petryshen, Tracey L.; Seidman, Larry Joel; McCarley, Robert William; Niznikiewicz, Margaret
    The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examined sex- and age-matched clinical high risk (CHR, n=21), first episode schizophrenia patients (FESZ, n=20) and matched healthy controls (HC, n=25) on oddball and novelty paradigms and assessed the N100, P200, P3a and P3b as indices of perceptual, attentional and working memory processes. To our knowledge, this is the only such comparison using all of these event-related potentials (ERPs) in two paradigms. We hypothesized that the ERPs would differentiate between the three groups and allow prediction of a diagnostic group. The majority of ERPs were significantly affected in CHR and FESZ compared with controls, with similar effect sizes. Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership.
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    Gamma Band Neural Synchronization Deficits for Auditory Steady State Responses in Bipolar Disorder Patients
    (Public Library of Science, 2012) Oda, Yuko; Onitsuka, Toshiaki; Tsuchimoto, Rikako; Hirano, Shogo; Ueno, Takefumi; Nakamura, Itta; Miura, Tomofumi; Kanba, Shigenobu; Oribe, Naoya; Hirano, Yoji
    Periodic auditory click stimulation has been reported to elicit an auditory steady state response (ASSR). The ASSR has been suggested to reflect the efficiency of γ-amino butyric acid (GABA) inhibitory interneuronal activity. Although a potential role for GABAergic dysfunction has been previously proposed, the role of neural synchronization in the ASSR in people with bipolar disorder (BD) has received little attention. In the current study, we investigated ASSRs to 20 Hz, 30 Hz, 40 Hz and 80 Hz click trains in BD patients. A total of 14 (4 males) BD patients and 25 (10 males) healthy controls participated in this study. ASSRs were obtained using whole-head 306-channel magnetoencephalography to calculate, ASSR power values and phase locking factors (PLF). BD patients exhibited significantly reduced mean ASSR power and PLF values bilaterally at frequencies of 30, 40, and 80 Hz (p<0.05 for these frequencies). At 20 Hz, bipolar patients showed no significant reduction in mean ASSR power and PLF values. There was a significant negative correlation between 80 Hz-ASSR-power values obtained from the right hemisphere and scores on the Hamilton Depression Rating Scale (rho = −0.86, p = 0.0003). The current study showed reduced low and high gamma band ASSR power and PLF bilaterally with no significant beta band ASSR reduction in BD patients. BD patients are characterized by deficits in gamma band oscillations, which may be associated with GABA inhibitory interneuronal activity dysfunction.