(Oxford University Press, 2018) Kalvari, Ioanna; Argasinska, Joanna; Quinones-Olvera, Natalia; Nawrocki, Eric P; Rivas, Elena; Eddy, Sean; Bateman, Alex; Finn, Robert D; Petrov, Anton I
Abstract The Rfam database is a collection of RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. In this paper we introduce Rfam release 13.0, which switches to a new genome-centric approach that annotates a non-redundant set of reference genomes with RNA families. We describe new web interface features including faceted text search and R-scape secondary structure visualizations. We discuss a new literature curation workflow and a pipeline for building families based on RNAcentral. There are 236 new families in release 13.0, bringing the total number of families to 2687. The Rfam website is http://rfam.org.
