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Lin, Pei-Yi

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Pei-Yi

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Lin, Pei-Yi

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2016 - 20183

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Author's Publications: search.filters.isAuthorOfPublication.9d7893f4-9df5-4347-98c5-9ea9e38fd78a

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Now showing 1 - 3 of 3
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    Reduced cerebral blood flow and oxygen metabolism in extremely preterm neonates with low-grade germinal matrix- intraventricular hemorrhage
    (Nature Publishing Group, 2016) Lin, Pei-Yi; Hagan, Katherine; Fenoglio, Angela; Grant, P.; Franceschini, Maria Angela
    Low-grade germinal matrix-intraventricular hemorrhage (GM-IVH) is the most common complication in extremely premature neonates. The occurrence of GM-IVH is highly associated with hemodynamic instability in the premature brain, yet the long-term impact of low-grade GM-IVH on cerebral blood flow and neuronal health have not been fully investigated. We used an innovative combination of frequency-domain near infrared spectroscopy and diffuse correlation spectroscopy (FDNIRS-DCS) to measure cerebral oxygen saturation (SO2) and an index of cerebral blood flow (CBFi) at the infant’s bedside and compute an index of cerebral oxygen metabolism (CMRO2i). We enrolled twenty extremely low gestational age (ELGA) neonates (seven with low-grade GM-IVH) and monitored them weekly until they reached full-term equivalent age. During their hospital stay, we observed consistently lower CBFi and CMRO2i in ELGA neonates with low-grade GM-IVH compared to neonates without hemorrhages. Furthermore, lower CBFi and CMRO2i in the former group persists even after the resolution of the hemorrhage. In contrast, SO2 does not differ between groups. Thus, CBFi and CMRO2i may have better sensitivity than SO2 in detecting GM-IVH-related effects on infant brain development. FDNIRS-DCS methods may have clinical benefit for monitoring the evolution of GM-IVH, evaluating treatment response, and potentially predicting neurodevelopmental outcome.
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    Shedding light on the neonatal brain: probing cerebral hemodynamics by diffuse optical spectroscopic methods
    (Nature Publishing Group UK, 2017) Farzam, Parisa; Buckley, Erin M.; Lin, Pei-Yi; Hagan, Katherine; Grant, P.; Inder, Terrie; Carp, Stefan; Franceschini, Maria Angela
    Investigating the cerebral physiology of healthy term newborns’ brains is important for better understanding perinatal brain injuries, of which the most common etiologies are hypoxia and ischemia. Hence, cerebral blood flow and cerebral oxygenation are important biomarkers of brain health. In this study, we employed a hybrid diffuse optical system consisting of diffuse correlation spectroscopy (DCS) and frequency-domain near infrared spectroscopy (FDNIRS) to measure hemoglobin concentration, oxygen saturation, and indices of cerebral blood flow and metabolism. We measured 30 term infants to assess the optical and physiological characteristics of the healthy neonatal brain in the frontal, temporal, and parietal lobes. We observed higher metabolism in the right hemisphere compared to the left and a positive correlation between gestational age and the level of cerebral hemoglobin concentration, blood volume, and oxygen saturation. Moreover, we observed higher cerebral blood flow and lower oxygen saturation in females compared to males. The delayed maturation in males and the sexual dimorphism in cerebral hemodynamics may explain why males are more vulnerable to perinatal brain injuries than females.
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    Publisher Correction: Shedding light on the neonatal brain: probing cerebral hemodynamics by diffuse optical spectroscopic methods
    (Nature Publishing Group UK, 2018) Farzam, Parisa; Buckley, Erin M.; Lin, Pei-Yi; Hagan, Katherine; Grant, P.; Inder, Terrie; Carp, Stefan; Franceschini, Maria Angela