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Annabi, Nasim

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Annabi

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Nasim

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Annabi, Nasim

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2017 - 20182

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Author's Publications: search.filters.isAuthorOfPublication.9f9ff79e-3bb6-44cb-a611-16fe618cc0f4

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    Visible light crosslinkable human hair keratin hydrogels
    (John Wiley and Sons Inc., 2018) Yue, Kan; Liu, Yanhui; Byambaa, Batzaya; Singh, Vaishali; Liu, Wanjun; Li, Xiuyu; Sun, Yunxia; Zhang, Yu; Tamayol, Ali; Zhang, Peihua; Ng, Kee Woei; Annabi, Nasim; Khademhosseini, Ali
    Abstract Keratins extracted from human hair have emerged as a promising biomaterial for various biomedical applications, partly due to their wide availability, low cost, minimal immune response, and the potential to engineer autologous tissue constructs. However, the fabrication of keratin‐based scaffolds typically relies on limited crosslinking mechanisms, such as via physical interactions or disulfide bond formation, which are time‐consuming and result in relatively poor mechanical strength and stability. Here, we report the preparation of photocrosslinkable keratin‐polyethylene glycol (PEG) hydrogels via the thiol‐norbornene “click” reaction, which can be formed within one minute upon irradiation of visible light. The resulting keratin‐PEG hydrogels showed highly tunable mechanical properties of up to 45 kPa in compressive modulus, and long‐term stability in buffer solutions and cell culture media. These keratin‐based hydrogels were tested as cell culture substrates in both two‐dimensional surface seeding and three‐dimensional cell encapsulation, demonstrating excellent cytocompatibility to support the attachment, spreading, and proliferation of fibroblast cells. Moreover, the photocrosslinking mechanism makes keratin‐based hydrogel suitable for various microfabrication techniques, such as micropatterning and wet spinning, to fabricate cell‐laden tissue constructs with different architectures. We believe that the unique features of this photocrosslinkable human hair keratin hydrogel promise new opportunities for their future biomedical applications.
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    Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
    (Nature Publishing Group UK, 2017) Tamayol, Ali; Hassani Najafabadi, Alireza; Mostafalu, Pooria; Yetisen, Ali K.; Commotto, Mattia; Aldhahri, Musab; Abdel-wahab, Mohamed Shaaban; Najafabadi, Zeynab Izadi; Latifi, Shahrzad; Akbari, Mohsen; Annabi, Nasim; Yun, Seok Hyun; Memic, Adnan; Dokmeci, Mehmet R.; Khademhosseini, Ali
    Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)- poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform’s biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.