Person:
Calhoun, William

Profile Picture

Email Address

AA Acceptance Date

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Calhoun

First Name

William

Name

Calhoun, William

Filters

20141

Settings

Author's Publications: search.filters.isAuthorOfPublication.a20ead70-c932-469b-82f7-93977aa22aa3

Search Results

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Publication
    Unsupervised Phenotyping of Severe Asthma Research Program Participants Using Expanded Lung Data
    (Elsevier BV, 2014-03-03) Wu, Wei; Bleecker, Eugene; Moore, Wendy; Busse, William W.; Castro, Mario; Chung, Kian Fan; Erzurum, Serpil; Gaston, Benjamin; Curran-Everett, Douglas; Wenzel, Sally E.; Calhoun, William; Israel, Elliot
    Background Previous studies have identified asthma phenotypes based on small numbers of clinical, physiologic or inflammatory characteristics. However, no studies have utilized a wide range of variables using machine learning approaches. Objectives To identify subphenotypes of asthma utilizing blood, bronchoscopic, exhaled nitric oxide and clinical data from the Severe Asthma Research Program using unsupervised clustering, and then characterize them using supervised learning approaches. Methods Unsupervised clustering approaches were applied to 112 clinical, physiologic and inflammatory variables from 378 subjects. Variable selection and supervised learning techniques were employed to select relevant and nonredundant variables, address their predictive values, as well as the predictive value of the full variable set. Results Ten variable clusters and six subject clusters were identified, which differed and overlapped with previous clusters. Traditionally defined severe asthmatics distributed through subject Clusters 3–6. Cluster 4 identified early onset allergic asthmatics with low lung function and eosinophilic inflammation. Later onset, mostly severe asthmatics with nasal polyps and eosinophilia characterized Cluster 5. Cluster 6 asthmatics manifested persistent inflammation in blood and bronchoalveolar lavage and exacerbations despite high systemic corticosteroid use and side effects. Age of asthma onset, quality of life, symptoms, medications and health care utilization were some of the 51 nonredundant variables distinguishing subject clusters. These 51 variables classified test cases with 88% accuracy, compared to 93% accuracy with all 112 variables. Conclusion The unsupervised machine learning approaches used here provide unique insights into disease, confirming other approaches while revealing novel additional phenotypes.