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Gale, Seth

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Gale

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Gale, Seth

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2014 - 20172

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Author's Publications: search.filters.isAuthorOfPublication.a84537b7-36eb-4fbb-8e23-e4ebd7324357

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    Recurrent Epileptic Auras As a Presenting Symptom of Alzheimer’s Disease
    (Frontiers Media S.A., 2017) Sarkis, Rani; Willment, Kim C.; Gale, Seth; Dworetzky, Barbara
    Seizures are a common co-morbidity during the course of Alzheimer’s disease (AD) and in a subset of patients may be one of the presenting symptoms. In this case series, we highlight three patients with recurrent medically refractory epileptic auras whose work up ultimately lead to the diagnosis of AD. All three patients underwent prolonged EEG, serial neuropsychological testing, FDG-PET, cerebrospinal fluid (CSF) AD biomarkers, and MRI. CSF biomarkers were particularly helpful in two cases. These cases highlight the importance of having a high index of suspicion for AD in new onset “idiopathic” epilepsy in the elderly.
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    Lateralized, nonepileptic convulsions in an adult with cerebral palsy: Case report and review of the literature☆
    (Elsevier, 2014) Gale, Seth; Safar, Laura; Robbins, Jeffrey; Daffner, Kirk
    The authors report a case of unilateral functional neurological symptoms (nonepileptic convulsions) in a 38-year-old man with mild, motor-predominant cerebral palsy. His convulsions are all lateralized to the same side as his paretic limbs. His episodes significantly decreased after several months of weekly psychodynamic-oriented psychotherapy. Functional neurological disorders have been rarely reported in children or adults with cerebral palsy. Among patients with brain injury, right-hemispheric brain disease may be more helpful than either handedness or the side of symptoms in clinically profiling patients with suspected functional disorders. This case raises biomechanistic questions about brain injury, the development of functional disorders, and the lateralization of functional symptoms.