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Lee, Wonhye

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Wonhye

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Lee, Wonhye
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    Publication
    Non-invasive transmission of sensorimotor information in humans using an EEG/focused ultrasound brain-to-brain interface
    (Public Library of Science, 2017) Lee, Wonhye; Kim, Suji; Kim, Byeongnam; Lee, Chungki; Chung, Yong An; Kim, Laehyun; Yoo, Seung-Schik
    We present non-invasive means that detect unilateral hand motor brain activity from one individual and subsequently stimulate the somatosensory area of another individual, thus, enabling the remote hemispheric link between each brain hemisphere in humans. Healthy participants were paired as a sender and a receiver. A sender performed a motor imagery task of either right or left hand, and associated changes in the electroencephalogram (EEG) mu rhythm (8–10 Hz) originating from either hemisphere were programmed to move a computer cursor to a target that appeared in either left or right of the computer screen. When the cursor reaches its target, the outcome was transmitted to another computer over the internet, and actuated the focused ultrasound (FUS) devices that selectively and non-invasively stimulated either the right or left hand somatosensory area of the receiver. Small FUS transducers effectively allowed for the independent administration of stimulatory ultrasonic waves to somatosensory areas. The stimulation elicited unilateral tactile sensation of the hand from the receiver, thus establishing the hemispheric brain-to-brain interface (BBI). Although there was a degree of variability in task accuracy, six pairs of volunteers performed the BBI task in high accuracy, transferring approximately eight commands per minute. Linkage between the hemispheric brain activities among individuals suggests the possibility for expansion of the information bandwidth in the context of BBI.
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    Publication
    5th International Symposium on Focused Ultrasound: North Bethesda, MD, USA. 28 August- 1 September 2016
    (BioMed Central, 2016) Zaaroor, Menashe; Sinai, Alon; Goldsher, Dorit; Eran, Ayelet; Nassar, Maria; Schlesinger, Ilana; Parker, Jonathon; Ravikumar, Vinod; Ghanouni, Pejman; Stein, Sherman; Halpern, Casey; Krishna, Vibhor; Hargrove, Amelia; Agrawal, Punit; Changizi, Barbara; Bourekas, Eric; Knopp, Michael; Rezai, Ali; Mead, Brian; Kim, Namho; Mastorakos, Panagiotis; Suk, Jung Soo; Miller, Wilson; Klibanov, Alexander; Hanes, Justin; Price, Richard; Wang, Shutao; Olumolade, Oluyemi; Kugelman, Tara; Jackson-Lewis, Vernice; Karakatsani, Maria Eleni (Marilena); Han, Yang; Przedborski, Serge; Konofagou, Elisa; Hynynen, Kullervo; Aubert, Isabelle; Leinenga, Gerhard; Nisbet, Rebecca; Hatch, Robert; Van der Jeugd, Anneke; Evans, Harrison; Götz, Jürgen; Van der Jeugd, Ann; Fishman, Paul; Yarowsky, Paul; Frenkel, Victor; Wei-Bin, Shen; Nguyen, Ben; Sanchez, Carlos Sierra; Acosta, Camilo; Chen, Cherry; Wu, Shih-Ying; Aryal, Muna; Papademetriou, Iason T.; Zhang, Yong-Zhi; Power, Chanikarn; McDannold, Nathan; Porter, Tyrone; Kovacs, Zsofia; Kim, Saejeong; Jikaria, Neekita; Qureshi, Farhan; Bresler, Michele; Frank, Joseph; Odéen, Henrik; Chiou, Jr-yuan; Snell, John; Todd, Nick; Madore, Bruno; Parker, Dennis; Pauly, Kim Butts; Marx, Mike; Jonathan, Sumeeth; Grissom, William; Arvanitis, Costas; Clement, Gregory; de Bever, Joshua; Payne, Allison; Christensen, Douglas; Maimbourg, Guillaume; Santin, Mathieu David; Houdouin, Alexandre; Lehericy, Stéphane; Tanter, Mickael; Aubry, Jean Francois; Federau, Christian; Werner, Beat; Paeng, Dong-Guk; Xu, Zhiyuan; Quigg, Anders; Eames, Matt; Jin, Changzhu; Everstine, Ashli; Sheehan, Jason; Lopes, M. Beatriz; Kassell, Neal; Drake, James; Price, Karl; Lustgarten, Lior; Sin, Vivian; Mougenot, Charles; Donner, Elizabeth; Tam, Emily; Hodaie, Mojgan; Waspe, Adam; Looi, Thomas; Pichardo, Samuel; Lee, Wonhye; Chung, Yong An; Jung, Yujin; Song, In-Uk; Yoo, Seung-Schik; Kim, Hyun-Chul; Lee, Jong-Hwan; Caskey, Charles; Zinke, Wolf; Cosman, Josh; Shuman, Jillian; Schall, Jeffrey; Aurup, Christian; Chen, Hong; Kamimura, Hermes; Carneiro, Antonio; Sun, Tao; Nazai, Navid; Patz, Sam; Livingstone, Margaret; Mainprize, Todd; Huang, Yuexi; Alkins, Ryan; Chapman, Martin; Perry, James; Lipsman, Nir; Bethune, Allison; Sahgal, Arjun; Trudeau, Maureen; Liu, Hao-Li; Hsu, Po-Hung; Wei, Kuo-Chen; Sutton, Jonathan; Alexander, Phillip; Miller, Eric; Kobus, Thiele; Carpentier, Alexandre; Canney, Michael; Vignot, Alexandre; Beccaria, Kevin; Leclercq, Delphine; Lafon, Cyril; Chapelon, Jean Yves; Hoang-Xuan, Khe; Delattre, Jean-Yves; Idbaih, Ahmed; Moore, David; Xu, Alexis; Schmitt, Paul; Foley, Jessica; Sukovich, Jonathan; Cain, Charles; Pandey, Aditya; Chaudhary, Neeraj; Camelo-Piragua, Sandra; Allen, Steven; Cannata, Jon; Teofilovic, Dejan; Bertolina, Jim; Hall, Timothy; Xu, Zhen; Grondin, Julien; Ferrera, Vincent; ter Haar, Gail; Mouratidis, Petros; Repasky, Elizabeth; Timbie, Kelsie; Badr, Lena; Campbell, Benjamin; McMichael, John; Buckner, Andrew; Prince, Jessica; Stevens, Aaron; Bullock, Timothy; Skalina, Karin; Guha, Chandan; Orsi, Franco; Bonomo, Guido; Vigna, Paolo Della; Mauri, Giovanni; Varano, Gianluca; Schade, George; Wang, Yak-Nam; Pillarisetty, Venu; Hwang, Joo Ha; Khokhlova, Vera; Bailey, Michael; Khokhlova, Tatiana; Sinilshchikov, Ilya; Yuldashev, Petr; Andriyakhina, Yulia; Kreider, Wayne; Maxwell, Adam; Sapozhnikov, Oleg; Partanen, Ari; Lundt, Jonathan; Preusser, Tobias; Haase, Sabrina; Bezzi, Mario; Jenne, Jürgen; Langø, Thomas; Midiri, Massimo; Mueller, Michael; Sat, Giora; Tanner, Christine; Zangos, Stephan; Guenther, Matthias; Melzer, Andreas; Menciassi, Arianna; Tognarelli, Selene; Cafarelli, Andrea; Diodato, Alessandro; Ciuti, Gastone; Rothluebbers, Sven; Schwaab, Julia; Strehlow, Jan; Mihcin, Senay; Tretbar, Steffen; Payen, Thomas; Palermo, Carmine; Sastra, Steve; Olive, Kenneth; Adams, Matthew; Salgaonkar, Vasant; Scott, Serena; Sommer, Graham; Diederich, Chris; Vidal-Jove, Joan; Perich, Eloi; Ruiz, Antonio; Velat, Manuela; Melodelima, David; Dupre, Aurelien; Vincenot, Jeremy; Yao, Chen; Perol, David; Rivoire, Michel; Tucci, Samantha; Mahakian, Lisa; Fite, Brett; Ingham, Elizabeth; Tam, Sarah; Hwang, Chang-il; Tuveson, David; Ferrara, Katherine; Scionti, Stephen; Chen, Lili; Cvetkovic, Dusica; Chen, Xiaoming; Gupta, Roohi; Wang, Bin; Ma, Charlie; Bader, Kenneth; Haworth, Kevin; Holland, Christy; Sanghvi, Narendra; Carlson, Roy; Chen, Wohsing; Chaussy, Christian; Thueroff, Stefan; Cesana, Claudio; Bellorofonte, Carlo; Wang, Qingguo; Wang, Han; Wang, Shengping; Zhang, Junhai; Bazzocchi, Alberto; Napoli, Alessandro; Staruch, Robert; Bing, Chenchen; Shaikh, Sumbul; Nofiele, Joris; Szczepanski, Debra; Staruch, Michelle Wodzak; Williams, Noelle; Laetsch, Theodore; Chopra, Rajiv; Rosenberg, Jarrett; Bitton, Rachelle; LeBlang, Suzanne; Meyer, Joshua; Hurwitz, Mark; Yarmolenko, Pavel; Celik, Haydar; Eranki, Avinash; Beskin, Viktoriya; Santos, Domiciano; Patel, Janish; Oetgen, Matthew; Kim, AeRang; Kim, Peter; Sharma, Karun; Chisholm, Alexander; Aleman, Dionne; Scipione, Roberto; Temple, Michael; Amaral, Joao Guilherme; Endre, Ruby; Lamberti-Pasculli, Maria; de Ruiter, Joost; Campbell, Fiona; Stimec, Jennifer; Gupta, Samit; Singh, Manoj; Hopyan, Sevan; Czarnota, Gregory; Brenin, David; Rochman, Carrie; Kovatcheva, Roussanka; Vlahov, Jordan; Zaletel, Katja; Stoinov, Julian; Bucknor, Matthew; Rieke, Viola; Shim, Jenny; Koral, Korgun; Lang, Brian; Wong, Carlos; Lam, Heather; Shinkov, Alexander; Hu, Jim; Zhang, Xi; Macoskey, Jonathan; Ives, Kimberly; Owens, Gabe; Gurm, Hitinder; Shi, Jiaqi; Pizzuto, Matthew; Dillon, Christopher; Christofferson, Ivy; Hilas, Elaine; Shea, Jill; Greillier, Paul; Ankou, Bénédicte; Bessière, Francis; Zorgani, Ali; Pioche, Mathieu; Kwiecinski, Wojciech; Magat, Julie; Melot-Dusseau, Sandrine; Lacoste, Romain; Quesson, Bruno; Pernot, Mathieu; Catheline, Stefan; Chevalier, Philippe; Marquet, Fabrice; Bour, Pierre; Vaillant, Fanny; Amraoui, Sana; Dubois, Rémi; Ritter, Philippe; Haïssaguerre, Michel; Hocini, Mélèze; Bernus, Olivier; Tebebi, Pamela; Burks, Scott; Milo, Blerta; Gertner, Michael; Zhang, Jimin; Wong, Andrew; Liu, Yu; Kheirolomoom, Azadeh; Seo, Jai; Watson, Katherine; Zhang, Hua; Foiret, Josquin; Borowsky, Alexander; Xu, Doudou; Thanou, Maya; Centelles, Miguell; Wright, Mike; Amrahli, Maral; So, Po-Wah; Gedroyc, Wladyslaw; Kneepkens, Esther; Heijman, Edwin; Keupp, Jochen; Weiss, Steffen; Nicolay, Klaas; Grüll, Holger; Nagle, Matthew; Nikolaeva, Anastasia V.; Terzi, Marina E.; Tsysar, Sergey A.; Cunitz, Bryan; Mourad, Pierre; Downs, Matthew; Yang, Georgiana; Wang, Qi; Chen, Johnny; Farry, Justin; Dixon, Adam; Du, Zhongmin; Dhanaliwala, Ali; Hossack, John; Ranjan, Ashish; Maples, Danny; Wardlow, Rachel; Malayer, Jerry; Ramachandran, Akhilesh; Namba, Hirofumi; Kawasaki, Motohiro; Izumi, Masashi; Kiyasu, Katsuhito; Takemasa, Ryuichi; Ikeuchi, Masahiko; Ushida, Takahiro; Crake, Calum; Kothapalli, Satya V. V. N.; Leighton, Wan; Wang, Zhaorui; Gach, H. Michael; Straube, William; Altman, Michael; Kim, Young-sun; Lim, Hyo Keun; Rhim, Hyunchul; van Breugel, Johanna; Braat, Manon; Moonen, Chrit; van den Bosch, Maurice; Ries, Mario; Marrocchio, Cristina; Dababou, Susan; Lee, Jae Young; Chung, Hyun Hoon; Kang, Soo Yeon; Kang, Kook Jin; Son, Keon Ho; Zhang, Dandan; Plata, Juan; Jones, Peter; Pascal-Tenorio, Aurea; Bouley, Donna; Bond, Aaron; Dallapiazza, Robert; Huss, Diane; Warren, Amy; Sperling, Scott; Gwinn, Ryder; Shah, Binit; Elias, W. Jeff; Curley, Colleen; Zhang, Ying; Negron, Karina; Abounader, Roger; Samiotaki, Gesthimani; Tu, Tsang-Wei; Papadakis, Georgios; Hammoud, Dima; Silvestrini, Matthew; Wolfram, Frank; Güllmar, Daniel; Reichenbach, Juergen; Hofmann, Denis; Böttcher, Joachim; Schubert, Harald; Lesser, Thomas G.; Almquist, Scott; Camarena, Francisco; Jiménez-Gambín, Sergio; Jiménez, Noé; Chang, Jin Woo; Chaplin, Vandiver; Griesenauer, Rebekah; Miga, Michael; Ellens, Nicholas; Airan, Raag; Quinones-Hinojosa, Alfredo; Farahani, Keyvan; Feng, Xue; Fielden, Samuel; Zhao, Li; Wintermark, Max; Meyer, Craig; Guo, Sijia; Lu, Xin; Zhuo, Jiachen; Xu, Su; Gullapalli, Rao; Gandhi, Dheeraj; Brokman, Omer; Baek, Hongchae; Kim, Hyungmin; Leung, Steven; Webb, Taylor; Vykhodtseva, Natalia; Nguyen, Thai-Son; Park, Chang Kyu; Park, Sang Man; Jung, Na Young; Kim, Min Soo; Chang, Won Seok; Jung, Hyun Ho; Plaksin, Michael; Weissler, Yoni; Shoham, Shy; Kimmel, Eitan; Rosnitskiy, Pavel B.; Krupa, Steve; Hazan, Eilon; Naor, Omer; Levy, Yoav; Maimon, Noam; Brosh, Inbar; Kahn, Itamar; Cahill, Jessica; Colas, Elodie Constanciel; Wydra, Adrian; Maev, Roman; Aly, Amirah; Sesenoglu-Laird, Ozge; Padegimas, Linas; Cooper, Mark; Waszczak, Barbara; Tehrani, Seruz; Slingluff, Craig; Larner, James; Andarawewa, Kumari; Ozhinsky, Eugene; Shah, Rutwik; Krug, Roland; Deckers, Roel; Linn, Sabine; Suelmann, Britt; Witkamp, Arjen; Vaessen, Paul; van Diest, Paul; Bartels, Lambertus W.; Bos, Clemens; Borys, Nicolas; Storm, Gert; Van der Wall, Elsken; Farr, Navid; Alnazeer, Moez; Katti, Prateek; Wood, Bradford; Farrer, Alexis; Ferrer, Cyril; de Senneville, Baudouin Denis; van Stralen, Marijn; Liu, Jingfei; Leach, J. Kent; Zidowitz, Stephan; Lee, Hsin-Lun; Hsu, Fang-Chi; Kuo, Chia-Chun; Jeng, Shiu-Chen; Chen, Tung-Ho; Yang, Nai-Yi; Chiou, Jeng-Fong; Kao, Yi-tzu; Pan, Chia-Hsin; Wu, Jing-Fu; Tsai, Yi-Chieh; Johnson, Sara; Li, Dawei; He, Ye; Karakitsios, Ioannis; Schwenke, Michael; Demedts, Daniel; Xiao, Xu; Cavin, Ian; Minalga, Emilee; Merrill, Robb; Hadley, Rock; Ramaekers, Pascal; de Greef, Martijn; Shahriari, Kian; Parvizi, Mohammad Hossein; Asadnia, Kiana; Chamanara, Marzieh; Kamrava, Seyed Kamran; Chabok, Hamid Reza; Stein, Ruben; Muller, Sébastien; Tan, Jeremy; Zachiu, Cornel; Erasmus, Hans-Peter; Van Arsdell, Glen; Benson, Lee; Jang, Kee W.; Angstadt, Mary; Lewis, Bobbi; McLean, Hailey; Hoogenboom, Martijn; Eikelenboom, Dylan; den Brok, Martijn; Wesseling, Pieter; Heerschap, Arend; Fütterer, Jurgen; Adema, Gosse; Wang, Kevin; Zhong, Pei; Joy, Joyce; McLeod, Helen; Kim, Harry; Lewis, Matthew; Ozilgen, Arda; Zahos, Peter; Coughlin, Dezba; Tang, Xinyan; Lotz, Jeff; Jedruszczuk, Kathleen; Gulati, Amitabh; Solomon, Stephen; Kaye, Elena; Mugler, John; Barbato, Gaetano; Scoarughi, Gian Luca; Corso, Cristiano; Gorgone, Alessandro; Migliore, Ilaria Giuseppina; Larrabee, Zachary; Hananel, Arik; Aubry, Jean-Francois; Negussie, Ayele; Wilson, Emmanuel; Seifabadi, Reza; Moon, Hyungwon; Kang, Jeeun; Sim, Changbeom; Chang, Jin Ho; Kim, Hyuncheol; Lee, Hak Jong; Sasaki, Noboru; Takiguchi, Mitsuyoshi; Sebeke, Lukas; Luo, Xi; de Jager, Bram; Heemels, Maurice; Abraham, Christopher; Curiel, Laura; Berriet, Rémi; Janát-Amsbury, Margit; Corea, Joseph; Ye, Patrick Peiyong; Arias, Ana Clauda; Lustig, Micheal; Svedin, Bryant
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    Functional and diffusion tensor magnetic resonance imaging of the sheep brain
    (BioMed Central, 2015) Lee, Wonhye; Lee, Stephanie D.; Park, Michael Y.; Foley, Lori; Purcell-Estabrook, Erin; Kim, Hyungmin; Yoo, Seung-Schik
    Background: An ovine model can cast great insight in translational neuroscientific research due to its large brain volume and distinct regional neuroanatomical structures. The present study examined the applicability of brain functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to sheep using a clinical MR scanner (3 tesla) with a head coil. The blood-oxygenation-level-dependent (BOLD) fMRI was performed on anesthetized sheep during the block-based presentation of external tactile and visual stimuli using gradient echo-planar-imaging (EPI) sequence. Results: The individual as well as group-based data processing subsequently showed activation in the eloquent sensorimotor and visual areas. DTI was acquired using 26 differential magnetic gradient directions to derive directional fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values from the brain. White matter tractography was also applied to reveal the macrostructure of the corticospinal tracts and optic radiations. Conclusions: Utilization of fMRI and DTI along with anatomical MRI in the sheep brain could shed light on a broader use of an ovine model in the field of translational neuroscientific research targeting the brain.
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    Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound
    (BioMed Central, 2016) Lee, Wonhye; Chung, Yong An; Jung, Yujin; Song, In-Uk; Yoo, Seung-Schik
    Background: Transcranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcranial magnetic stimulation or transcranial direct current stimulation. We examined the presence of tactile sensations elicited by FUS stimulation of two separate brain regions in humans—the primary (SI) and secondary (SII) somatosensory areas of the hand, as guided by individual-specific functional magnetic resonance imaging data. Results: Under image-guidance, acoustic stimulations were delivered to the SI and SII areas either separately or simultaneously. The SII areas were divided into sub-regions that are activated by four types of external tactile sensations to the palmar side of the right hand—vibrotactile, pressure, warmth, and coolness. Across the stimulation conditions (SI only, SII only, SI and SII simultaneously), participants reported various types of tactile sensations that arose from the hand contralateral to the stimulation, such as the palm/back of the hand or as single/neighboring fingers. The type of tactile sensations did not match the sensations that are associated with specific sub-regions in the SII. The neuro-stimulatory effects of FUS were transient and reversible, and the procedure did not cause any adverse changes or discomforts in the subject’s mental/physical status. Conclusions: The use of multiple FUS transducers allowed for simultaneous stimulation of the SI/SII in the same hemisphere and elicited various tactile sensations in the absence of any external sensory stimuli. Stimulation of the SII area alone could also induce perception of tactile sensations. The ability to stimulate multiple brain areas in a spatially restricted fashion can be used to study causal relationships between regional brain activities and their cognitive/behavioral outcomes. Electronic supplementary material The online version of this article (doi:10.1186/s12868-016-0303-6) contains supplementary material, which is available to authorized users.
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    Transcranial focused ultrasound stimulation of human primary visual cortex
    (Nature Publishing Group, 2016) Lee, Wonhye; Kim, Hyun-Chul; Jung, Yujin; Chung, Yong An; Song, In-Uk; Lee, Jong-Hwan; Yoo, Seung-Schik
    Transcranial focused ultrasound (FUS) is making progress as a new non-invasive mode of regional brain stimulation. Current evidence of FUS-mediated neurostimulation for humans has been limited to the observation of subjective sensory manifestations and electrophysiological responses, thus warranting the identification of stimulated brain regions. Here, we report FUS sonication of the primary visual cortex (V1) in humans, resulting in elicited activation not only from the sonicated brain area, but also from the network of regions involved in visual and higher-order cognitive processes (as revealed by simultaneous acquisition of blood-oxygenation-level-dependent functional magnetic resonance imaging). Accompanying phosphene perception was also reported. The electroencephalo graphic (EEG) responses showed distinct peaks associated with the stimulation. None of the participants showed any adverse effects from the sonication based on neuroimaging and neurological examinations. Retrospective numerical simulation of the acoustic profile showed the presence of individual variability in terms of the location and intensity of the acoustic focus. With exquisite spatial selectivity and capability for depth penetration, FUS may confer a unique utility in providing non-invasive stimulation of region-specific brain circuits for neuroscientific and therapeutic applications.