(Royal Society of Chemistry, 2018) Liu, Wei; Huang, Xiongyi; Placzek, MIchael; Krska, Shane W.; McQuade, Paul; Hooker, Jacob; Groves, John T.
The first direct C–H 18F fluorination reaction of unactivated aliphatic sites using no-carrier-added [18F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C–H bonds can be selectively converted to C–18F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of 18F labeled radio tracers.
