Person:
Touroutoglou, Alexandra

Profile Picture

Email Address

AA Acceptance Date

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Touroutoglou

First Name

Alexandra

Name

Touroutoglou, Alexandra

Filters

20172

Settings

Author's Publications: search.filters.isAuthorOfPublication.ad819be1-f441-4da1-90ff-6aa314ddc6c7

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans
    (2017) Kleckner, Ian R.; Zhang, Jiahe; Touroutoglou, Alexandra; Chanes, Lorena; Xia, Chenjie; Simmons, W. Kyle; Quigley, Karen S.; Dickerson, Bradford; Barrett, Lisa Feldman
    Large-scale intrinsic brain systems have been identified for exteroceptive senses (e.g., sight, hearing, touch). We introduce an analogous system for representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral systems in the body, called allostasis. Employing the recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two intrinsic functional magnetic resonance imaging samples (N = 280 and N = 270) to evaluate the existence of an intrinsic allostatic/interoceptive system in the human brain. Another sample (N = 41) allowed us to evaluate the convergent validity of the hypothesized allostatic/interoceptive system by showing that individuals with stronger connectivity between system hubs performed better on an implicit index of interoceptive ability related to autonomic fluctuations. Implications include insights for the brain’s functional architecture, dissolving the artificial boundary between mind and body, and unifying mental and physical illness.
  • Thumbnail Image
    Publication
    Resting connectivity between salience nodes predicts recognition memory
    (Oxford University Press, 2017) Andreano, Joseph M.; Touroutoglou, Alexandra; Dickerson, Bradford; Barrett, Lisa F.
    Abstract The resting connectivity of the brain’s salience network, particularly the ventral subsystem of the salience network, has been previously associated with various measures of affective reactivity. Numerous studies have demonstrated that increased affective arousal leads to enhanced consolidation of memory. This suggests that individuals with greater ventral salience network connectivity will exhibit greater responses to affective experience, leading to a greater enhancement of memory by affect. To test this hypothesis, resting ventral salience connectivity was measured in 41 young adults, who were then exposed to neutral and negative affect inductions during a paired associate memory test. Memory performance for material learned under both negative and neutral induction was tested for correlation with resting connectivity between major ventral salience nodes. The results showed a significant interaction between mood induction (negative vs neutral) and connectivity between ventral anterior insula and pregenual anterior cingulate cortex, indicating that salience node connectivity predicted memory for material encoded under negative, but not neutral induction. These findings suggest that the network state of the perceiver, measured prior to affective experience, meaningfully influences the extent to which affect modulates memory. Implications of these findings for individuals with affective disorder, who show alterations in both connectivity and memory, are considered.