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Ehrlicher, Allen Joseph

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Ehrlicher

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Allen Joseph

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Ehrlicher, Allen Joseph

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2010 - 20132

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Author's Publications: search.filters.isAuthorOfPublication.aeaa85bb-2270-49e0-ae05-0a1892e0cb2c

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    Microwave dielectric heating of non-aqueous droplets in a microfluidic device for nanoparticle synthesis
    (Royal Society of Chemistry (RSC), 2013) Koziej, Dorota; Floryan, Caspar Jerzy; Sperling, Ralph A.; Ehrlicher, Allen Joseph; Issadore, David; Westervelt, Robert; Weitz, David
    We describe a microfluidic device with an integrated microwave heater specifically designed to dielectrically heat non-aqueous droplets using time-varying electrical fields with the frequency range between 700 and 900 MHz. The precise control of frequency, power, temperature and duration of the applied field opens up new vistas for experiments not attainable by conventional microwave heating. We use a non-contact temperature measurement system based on fluorescence to directly determine the temperature inside a single droplet. The maximum temperature achieved of the droplets is 50 °C in 15 ms which represents an increase of about 25 °C above the base temperature of the continuous phase. In addition we use an infrared camera to monitor the thermal characteristics of the device allowing us to ensure that heating is exclusively due to the dielectric heating and not due to other effects like non-dielectric losses due to electrode or contact imperfection. This is crucial for illustrating the potential of dielectric heating of benzyl alcohol droplets for the synthesis of metal oxides. We demonstrate the utility of this technology for metal oxide nanoparticle synthesis, achieving crystallization of tungsten oxide nanoparticles and remarkable microstructure, with a reaction time of 64 ms, a substantial improvement over conventional heating methods.
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    Cytoskeletal Mechanics of Proplatelet Maturation and Platelet Release
    (Rockefeller University Press, 2010) Thon, Jonathan; Montalvo, Alejandro; Patel-Hett, Sunita; Devine, Matthew T.; Richardson, Jennifer L.; Ehrlicher, Allen Joseph; Larson, Mark K.; Hoffmeister, Karin; Hartwig, John; Italiano, Joseph
    Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Although the mechanics of proplatelet elongation have been studied, the terminal steps of proplatelet maturation and platelet release remain poorly understood. To elucidate this process, released proplatelets were isolated, and their conversion into individual platelets was assessed. This enabled us to (a) define and quantify the different stages in platelet maturation, (b) identify a new intermediate stage in platelet production, the preplatelet, (c) delineate the cytoskeletal mechanics involved in preplatelet/proplatelet interconversion, and (d) model proplatelet fission and platelet release. Preplatelets are anucleate discoid particles 2–10 \(\mu\)m across that have the capacity to convert reversibly into elongated proplatelets by twisting microtubule-based forces that can be visualized in proplatelets expressing GFP–\(\beta\)1-tubulin. The release of platelets from the ends of proplatelets occurs at an increasing rate in time during culture, as larger proplatelets undergo successive fission, and is potentiated by shear.