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Vitelli, Vincenzo

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Vitelli, Vincenzo

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    Observation of topological action potentials in engineered tissues
    (Springer Science and Business Media LLC, 2022-12-22) Ori, Hillel; Duque, Marc; Frank Hayward, Rebecca; Scheibner, Colin; Tian, He; Ortiz, Gloria; Vitelli, Vincenzo; Cohen, Adam
    Due to the nonlinear current-voltage relations of ion channels, an interface between two tissues can have very different bioelectrical properties compared to either tissue on its own. Here we show experimentally that gap junction-coupled interfaces between non-excitable tissues can be electrically excitable. This topologically protected excitability occurs over a far larger range of ion channel expression levels than does excitability in the bulk. Topological excitations at tissue interfaces can cause local elevations in calcium concentration, possibly providing a bioelectrical mechanism for interface sensing. As in condensed matter physics, topological excitations in electrophysiology constitute a distinct class of phenomena which may show exotic and novel properties.