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Addo, Marylyn Martina

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Marylyn Martina

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Addo, Marylyn Martina

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Author's Publications: search.filters.isAuthorOfPublication.b3f7128e-8acd-462b-9648-7245f8546d0dStart date: 2010

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    Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals

    (Oxford University Press, 2011) Brainard, Diana M.; Rathod, Almas; Piechocka-Trocha, Alicja; Fideli, Ulgen; Mulenga, Joseph; Shutes, Erin; Alvino, Donna Marie L.; Hunter, Eric; Allen, Susan A.; Addo, Marylyn Martina; Altfeld, Marcus; Walker, Bruce

    Human immunodeficiency virus type 1 (HIV-1)–specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1–specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1–specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1–specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.