Person: Cohen, Pieter
Loading...
Email Address
AA Acceptance Date
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
Cohen
First Name
Pieter
Name
Cohen, Pieter
23 results
Search Results
Now showing 1 - 10 of 23
Publication Analysis of Ingredients of Supplements in the National Institutes of Health Supplement Database Marketed as Containing a Novel Alternative to Anabolic Steroids(American Medical Association (AMA), 2020-04-15) Cohen, Pieter; Sharfstein, Joshua; Kamugisha, Angélique; Vanhee, CélinePublication Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case Report(American College of Physicians, 2015-06-16) Cohen, Pieter; Zeijlon, Rickard; Nardin, Rachel; Keizers, Peter H.J.; Venhuis, BastiaanPublication The stimulant higenamine in weight loss and sports supplements(Informa UK Limited, 2018-09-06) Cohen, Pieter; Travis, John C.; Keizers, Peter H. J.; Boyer, Frederick E.; Venhuis, Bastiaan J.Background: Higenamine is a stimulant with cardiovascular properties recently prohibited in sport by the World Anti-Doping Agency (WADA). Higenamine is also a natural constituent of several traditional botanical remedies and is listed as an ingredient in weight loss and sports supplements sold over-the- counter in the United States. Objectives: We analyzed dietary supplements available for sale in the United States prior to WADA’s prohibition of higenamine in sport for the presence and quantity of higenamine. Methods: All supplements labeled as containing higenamine or a synonym (i.e., norcoclaurine or demethylcoclaurine) available for sale in the United States were identified. For each brand, one sample was analyzed by NSF International (Ann Arbor, MI) and one sample by the Netherland’s National Institute for Public Health and the Environment (RIVM). NSF International carried out qualitative and quantitative analyses using ultra high performance liquid chromatography (UHPLC) with tandem mass spectrometry. RIVM carried out qualitative analysis using UHPLC quadrupole time of flight mass spec- trometry for an independent confirmation of identity. Results: Twenty-four products were analyzed. The majority of supplements were marketed as either weight loss (11/24; 46%) or sports/energy supplements (11/24; 46%); two brands did not list a labeled indication. The quantity of higenamine (±95% CI) ranged from trace amounts to 62±6.0mg per serv- ing. Consumers could be exposed to up to 110 ± 11 mg of higenamine per day when following recom- mended serving sizes provided on the label. Five products (5/24; 21%) listed an amount of higenamine, but none were accurately labeled; the quantity in these supplements ranged from <0.01% to 200% of the quantity listed on the label. Conclusion: Dosages of up to 62 ± 6.0 mg per serving of the stimulant higenamine were found in diet- ary supplements sold in the United States.Publication Variability in strength of red yeast rice supplements purchased from mainstream retailers(SAGE Publications, 2017-06-23) Cohen, Pieter; Avula, Bharathi; Khan, Ikhlas AThe United States Food and Drug Administration (FDA) has introduced manufacturing standards for dietary supple- ments, including red yeast rice, to assure their identity, purity, strength, and composition. One supplement commonly used to self-treat high cholesterol, red yeast rice, may contain monacolin K, an ingredient identical to prescription lovastatin. We examined whether FDA’s manufacturing standards led to standard concentrations of the statin monacolin K in red yeast rice supplements. We analyzed 28 brands of red yeast rice supplements by ultra-high performance liquid chromatography-diode array detector-quadrupole time-of-flight mass spectrometry for monacolin K content. Monacolin K was not detected in two brands. In the 26 brands that contained monacolin K, the quantity ranged more than 60-fold from 0.09 to 5.48 mg per 1200 mg of red yeast rice. Following the manufacturers’ recommendations for daily servings, the quantity of monacolin K consumed per day would range more than 120-fold from 0.09 to 10.94 mg. Despite FDA manufacturing standards, strength and composition of red yeast rice supplements sold at mainstream retail stores in the United States remains unpredictable.Publication Contaminated Dietary Supplements(Massachusetts Medical Society, 2010-01-21) Cohen, PieterPublication American Roulette — Contaminated Dietary Supplements(New England Journal of Medicine (NEJM/MMS), 2009) Cohen, PieterPublication Assessing Supplement Safety — The FDA's Controversial Proposal(New England Journal of Medicine (NEJM/MMS), 2012) Cohen, PieterPublication Hazards of Hindsight — Monitoring the Safety of Nutritional Supplements(New England Journal of Medicine (NEJM/MMS), 2014) Cohen, PieterPublication Contaminated Dietary Supplements(Massachusetts Medical Society, 2010-01-21) Cohen, PieterPublication Presence of Banned Drugs in Dietary Supplements Following FDA Recalls(American Medical Association (AMA), 2014) Cohen, Pieter; Maller, Gregory; DeSouza, Renan; Neal-Kababick, James
- «
- 1 (current)
- 2
- 3
- »