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Hornstein, Mark

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Hornstein

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Hornstein, Mark
Author's Publications: search.filters.isAuthorOfPublication.c06d3901-d138-4932-8e69-a5bc7483e827

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Now showing 1 - 6 of 6
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    Physical activity and semen quality among men attending an infertility clinic
    (Elsevier BV, 2011) Wise, Lauren A.; Cramer, Daniel; Hornstein, Mark; Ashby, Rachel; Missmer, Stacey
    OBJECTIVE To examine the association between regular physical activity and semen quality. DESIGN Prospective cohort study. SETTING Couples attending one of three IVF clinics in the greater Boston area during 1993–2003. At study entry, male participants completed a questionnaire about their general health, medical history, and physical activity. Odds ratios (OR) and 95% confidence intervals (CI) were derived using generalized estimating equations models, accounting for potential confounders and multiple samples per man. PATIENTS A total of 2,261 men contributing 4,565 fresh semen samples were enrolled before undergoing their first IVF cycle. INTERVENTION None. MAIN OUTCOME MEASURES Semen volume, sperm concentration, sperm motility, sperm morphology, and total motile sperm (TMS). RESULTS Overall, none of the semen parameters was materially associated with regular exercise. Compared with no regular exercise, bicycling ≥5 hours per week was associated with low sperm concentration (OR=1.92, 95%CI=1.03–3.56) and low TMS (OR=2.05, 95%CI=1.19–3.56). These associations did not vary appreciably by age, body mass index, or history of male factor infertility. CONCLUSIONS While the present study suggests no overall association between regular physical activity and semen quality, bicycling at levels of ≥5 hours per week was associated with lower sperm concentration and TMS.
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    Does a woman’s educational attainment influence in vitro fertilization outcomes?
    (Elsevier BV, 2011) Mahalingaiah, Shruthi; Berry, Katharine F.; Hornstein, Mark; Cramer, Daniel; Missmer, Stacey
    The association between educational level and cycle outcomes was quantified by applying multivariable logistic and linear regression within a prospective cohort of 2,569 women commencing their first in vitro fertilization (IVF) cycle. Although a woman’s educational attainment was not associated with the likelihood of implantation failure, chemical pregnancy, spontaneous abortion, or live birth, the odds of cycle cancellation before egg retrieval were 40% lower among those with an college degree and 48% lower among those with graduate school attendance compared with women who had no college degree, suggesting that educational attainment is inversely associated with the likelihood of cycle cancellation.
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    A Proteomic Analysis of IVF Follicular Fluid in Women ≤32 Years Old
    (Elsevier BV, 2009) Estes, Stephanie J.; Ye, Bin; Qiu, Weiliang; Cramer, Daniel; Hornstein, Mark; Missmer, Stacey
    Objective To address the lack of predictors of IVF success by using proteomic biometrics. Design Experimental study of follicular fluid specimens from a prospective cohort of IVF patients. Setting Academic research laboratory and IVF program. Patient(s) Women ≤32 years old with <11 oocytes retrieved and no pregnancy were matched to women who had ≥ 11 oocytes and live birth (10 pairs). Year of cycle start and IVF down-regulation protocol were also matched. Intervention(s) Follicular fluid was separated by two-dimensional polyacrylamide gel electrophoresis followed by Sypro Ruby staining and comparison with PDQuest software. Logistic regression was incorporated to calculate the likelihood of live birth in relation to the protein spot of interest. Main Outcome Measure(s) Protein markers. Result(s) Liquid chromatography–tandem mass spectrometry and searching of sequence databases revealed 11 potential protein candidates. Haptoglobin alpha, predominantly fetal expressed T1 domain, mitochondrial integrity genome (ATPase), apolipoprotein H (beta-2 glycoprotein I), dihydrolipoyl dehydrogenase, lyzozyme C, fibrinogen alpha-chain, and immunoglobulin heavy chain V-III (region BRO) were found to have increased expression in the live birth group, whereas antithrombin, vitamin D–binding protein, and complement 3 were decreased. An ELISA confirmed a significantly lower level of antithrombin. Conclusion(s) Proteomic evaluation of follicular fluid is able to identify potential biomarkers of good versus poor responders in matched pairs of IVF patients.
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    Association between endometriosis, dysplastic naevi and history of melanoma in women of reproductive age
    (Oxford University Press (OUP), 1997) Hornstein, Mark; Thomas, Paul Patrick; Sober, Arthur; Wyshak, Grace; Albright, N. L.; Frisch, Rose
    Women with melanoma and its precursor lesions, dysplastic naevi, have a higher prevalence of reproductive disorders than women without melanotic lesions. This association appears strongest among young women with dysplastic naevi and endometriosis. The purpose of this study was to evaluate patients with laparoscopy-confirmed endometriosis for the presence of dysplastic naevi. A total of 66 endometriosis patients and 35 controls completed a detailed questionnaire and underwent an extensive dermatological examination for the presence of dysplastic naevi. In all, 41% of patients aged < or = 32 years had dysplastic naevi, compared with 8% of controls (P = 0.038). In addition, 29% of patients with endometriosis reported a family history of melanoma compared with 10% of controls (P = 0.039). This study demonstrated an association between endometriosis and dysplastic naevi in younger women of reproductive age and found an associated family history of melanoma among endometriosis patients. These observations may be useful in the evaluation and care of young women by both gynaecologists and dermatologists.
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    Effect of Alcohol Consumption on In Vitro Fertilization
    (Ovid Technologies (Wolters Kluwer Health), 2011) Rossi, Brooke V.; Berry, Katharine F.; Hornstein, Mark; Cramer, Daniel; Ehrlich, Shelley; Missmer, Stacey
    To estimate whether alcohol use at the initiation of an in vitro fertilization (IVF) cycle is associated with IVF outcomes. METHODS In this prospective cohort study, men and women completed a self-administered questionnaire before their first IVF cycle. Participants reported alcohol type, amount, and frequency consumed. Discrete survival analysis was applied to calculate the odds ratio (OR) and 95% confidence interval (CI) for live birth—the primary outcome. Secondary outcomes were cycle characteristics and points of failure in the IVF process (cycle cancellation, failed fertilization, implantation failure, and spontaneous abortion). We conducted multicycle analyses with final models adjusted for potential confounders that included cycle number, cigarette use, body mass index, and age. RESULTS A total of 2,545 couples contributed 4,729 cycles. Forty-one percent of women and 58% of men drank one to six drinks per week. Women drinking at least four drinks per week had 16% less odds of a live birth rate compared with those who drank fewer than four drinks per week (OR 0.84, CI 0.71–0.99). For couples in which both partners drank at least four drinks per week, the odds of live birth were 21% lower compared with couples in which both drank fewer than four drinks per week (OR 0.79; CI 0.66–0.96). CONCLUSION Consumption of as few as four alcoholic drinks per week is associated with a decrease in IVF live birth rate.
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    Lifestyle and in vitro fertilization: what do patients believe?
    (BioMed Central, 2016) Rossi, Brooke V.; Bressler, Leah Hawkins; Correia, Katharine F.; Lipskind, Shane; Hornstein, Mark; Missmer, Stacey
    Background: Patients have many beliefs regarding lifestyle factors and IVF outcomes. Methods: Observational study of 208 IVF patients at an academic infertility center. Main outcome measures were perceived influence of various lifestyle factors assessed by multivariable logistic regression and p-value tests for linear trend (Pt). Results: A majority of participants believed that there were many women’s lifestyle choices that were influential, compared to fewer male factors (cessation of tobacco (72 %), alcohol (69 %), caffeine (62 %), and use of vitamins (88 %)). Compared to participants with less education, participants with a higher education level were less likely to believe vitamins were helpful and some alcohol use was not harmful. As income decreased, participants were less likely to consider dietary factors contributory to IVF success, such as women (p-trend, p = 0.02) and men (p-trend, p = 0.009) consuming a full-fat dairy diet. Participants’ beliefs were most commonly influenced by physicians (84 %) and the internet (71 %). Conclusions: Patients believed many lifestyle factors are associated with IVF success. Understanding patients’ assumptions regarding the effect of lifestyle factors on IVF success may better allow physicians to counsel patients about IVF outcomes. Electronic supplementary material The online version of this article (doi:10.1186/s40738-016-0026-5) contains supplementary material, which is available to authorized users.