Person:

Devor, Anna

Profile Picture

Email Address

AA Acceptance Date

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Devor

First Name

Anna

Name

Devor, Anna
Author's Publications: search.filters.isAuthorOfPublication.c4fee0eb-1147-49f7-a66a-e954bfcf48dfSubject: search.filters.subject.dilation

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication

    Cell type specificity of neurovascular coupling in cerebral cortex

    (eLife Sciences Publications, Ltd, 2016) Uhlirova, Hana; Kılıç, Kıvılcım; Tian, Peifang; Thunemann, Martin; Desjardins, Michèle; Saisan, Payam A; Sakadzic, Sava; Ness, Torbjørn V; Mateo, Celine; Cheng, Qun; Weldy, Kimberly L; Razoux, Florence; Vandenberghe, Matthieu; Cremonesi, Jonathan A; Ferri, Christopher GL; Nizar, Krystal; Sridhar, Vishnu B; Steed, Tyler C; Abashin, Maxim; Fainman, Yeshaiahu; Masliah, Eliezer; Djurovic, Srdjan; Andreassen, Ole A; Silva, Gabriel A; Boas, David; Kleinfeld, David; Buxton, Richard B; Einevoll, Gaute T; Dale, Anders M; Devor, Anna

    Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease. DOI: http://dx.doi.org/10.7554/eLife.14315.001

  • Thumbnail Image
    Publication

    Neurovascular Network Explorer 1.0: a database of 2-photon single-vessel diameter measurements with MATLAB® graphical user interface

    (Frontiers Media S.A., 2014) Sridhar, Vishnu B.; Tian, Peifang; Dale, Anders M.; Devor, Anna; Saisan, Payam A.

    We present a database client software—Neurovascular Network Explorer 1.0 (NNE 1.0)—that uses MATLAB® based Graphical User Interface (GUI) for interaction with a database of 2-photon single-vessel diameter measurements from our previous publication (Tian et al., 2010). These data are of particular interest for modeling the hemodynamic response. NNE 1.0 is downloaded by the user and then runs either as a MATLAB script or as a standalone program on a Windows platform. The GUI allows browsing the database according to parameters specified by the user, simple manipulation and visualization of the retrieved records (such as averaging and peak-normalization), and export of the results. Further, we provide NNE 1.0 source code. With this source code, the user can database their own experimental results, given the appropriate data structure and naming conventions, and thus share their data in a user-friendly format with other investigators. NNE 1.0 provides an example of seamless and low-cost solution for sharing of experimental data by a regular size neuroscience laboratory and may serve as a general template, facilitating dissemination of biological results and accelerating data-driven modeling approaches.