(BioMed Central, 2007) Zhu, Xiaopeng; Zhang, Xinmin; Chen, Runsheng; Manrai, Arjun K; Song, Jun S; Johnson, W. Evan; Li, Wei; Liu, Xiaole; Liu, Jun
A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates of the model parameters, is shown to perform superbly on published data sets. A robust algorithm for detecting peak regions is also formulated and shown to perform well compared to other approaches. The tools have been implemented as a stand-alone Java program called MA2C, which can display various plots of statistical analysis for quality control.
