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Chi, Anthony Wei Shine

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Chi

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Anthony Wei Shine

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Chi, Anthony Wei Shine
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    Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
    (Elsevier BV, 2014) Suva, Mario; Rheinbay, Esther; Gillespie, Shawn M.; Patel, Anoop Premswaroop; Wakimoto, Hiroaki; Rabkin, Samuel; Riggi, Nicolo; Chi, Anthony Wei Shine; Cahill, Daniel; Nahed, Brian; Curry, William; Martuza, Robert; Rivera, Miguel; Rossetti, Nikki; Kasif, Simon; Beik, Samantha Petrillo; Kadri, Sabah; Tirosh, Itay; Wortman, Ivo; Shalek, Alex K.; Rozenblatt-Rosen, Orit; Regev, Aviv; Louis, David; Bernstein, Bradley
    Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies reminiscent of normal development but superimposed on underlying genetic aberrations. In glioblastoma (GBM), a subset of stem-like tumor-propagating cells (TPCs) appears to drive tumor progression and underlie therapeutic resistance, yet remain poorly understood. Here, we identify a core set of neurodevelopmental TFs (POU3F2, SOX2, SALL2, OLIG2) essential for GBM propagation. These TFs coordinately bind and activate TPC-specific regulatory elements, and are sufficient to fully reprogram differentiated GBM cells to ‘induced’ TPCs, recapitulating the epigenetic landscape and phenotype of native TPCs. We reconstruct a network model that highlights critical interactions and identifies novel therapeutic targets for eliminating TPCs. Our study establishes the epigenetic basis of a developmental hierarchy in GBM, provides detailed insight into underlying gene regulatory programs, and suggests attendant therapeutic strategies.
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    Multimodal Therapy of an Intramedullary Cervical Primitive Neuroectodermal Tumor in an Adult
    (American Society of Clinical Oncology (ASCO), 2012) Coumans, Jean-Valery; Walcott, B. P.; Nahed, Brian; Oh, Kevin; Chi, Anthony Wei Shine
    Primitive neuroectodermal tumors (PNETs) are malignant, poorly differentiated neoplasms derived from the neural crest.1 They include cerebellar medulloblastomas but can also arise in the cerebral cortex (supratentorial PNETs), pineal region (pineoblastomas), spinal cord, cauda equina, and peripheral nerves.2 Only a few cases of primary intraspinal PNETs have been reported in children3-14 and in adults.15-17 To our knowledge, there has only been one previously reported case of intramedullary PNET of the cervical spine in an adult.17 In this article, we present a rare adult patient with a primary intramedullary cervical PNET and describe his treatment regimen and outcome.