Person: Ding, Ming
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Ding, Ming
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Publication Bone Mineral Density of the Spine in 11,898 Chinese Infants and Young Children: A Cross-Sectional Study(Public Library of Science, 2013) Xu, Haiqing; Zhao, Zhiwei; Wang, Hong; Ding, Ming; Zhou, Aiqin; Wang, Xiaoyan; Zhang, Ping; Duggan, Christopher; Hu, FrankBackground: Bone mineral density (BMD) increases progressively during childhood and adolescence and is affected by various genetic and environmental factors. The aim of this study was to establish reference values for lumbar BMD in healthy Chinese infants and young children and investigate its influencing factors. Methods and Findings: Healthy children aged 0 to 3 years who underwent regular physical examinations at the Child Health Care Clinic of Hubei Maternal and Child Health Hospital (N = 11,898) were recruited for this study. We also chose 379 preterm infants aged 0 to 1 years to preliminarily explore the development of BMD in this special population. BMD (g/cm2) measurements of the lumbar spine (L2–L4) were carried out with dual-energy X-ray absorptiometry and a questionnaire was administered to full-term children's parents to gather information on various nutritional and lifestyle factors as well as mothers' nutritional supplement use during pregnancy. Lumbar BMD significantly increased with age among both boys and girls (p<0.05), with fastest growth observed during the first postnatal year. There was no significant difference in lumbar BMD between boys and girls of similar age (p>0.05), either among healthy reference children or preterm infants. However, BMD values in preterm infants were significantly lower than those in term infants 3 to 8 months old (p<0.05) after adjustment for gestational age. Multivariable linear regression analysis indicated significant positive associations between lumbar BMD of healthy children and the child's age and current weight, mother's weight gain during pregnancy, birth weight, children's outdoor activity duration and children's physical activity duration. Conclusion: Our study provides reference values of lumbar BMD for healthy Chinese children aged 0 to 3 years and identifies several influencing factors.Publication Trajectories of length, weight, and bone mineral density among preterm infants during the first 12 months of corrected age in China(BioMed Central, 2015) Zhao, Zhiwei; Ding, Ming; Hu, Zubin; Dai, Qiong; Satija, Ambika; Zhou, Aiqin; Xu, Yusong; Zhang, Xuan; Hu, Frank; Xu, HaiqingBackground: Limited evidence has been provided on the trajectories of length, weight, and bone mineral density (BMD) among preterm infants in early life in Asian countries. Methods: We conducted a longitudinal study, which included 652 late preterm (gestational age: 34–36.9 weeks), 486 moderate preterm (32–33.9), 291 very preterm (28–31.9), 149 extremely preterm infants (≤28.9) and 1434 full-term peers (≥37) during the first 12 months of corrected age in Wuhan, China. Weight and length were measured at birth, once randomly before term, and every month thereafter. BMD was examined at 3, 6, 9 and 12 months using dual-energy X-ray absorptiometry. Results: From birth to 12 months of corrected age, growth peaks in length and weight were observed at 1–3 months among preterm infants. No catch-up growth in length, weight, and BMD was observed among preterm infants. However, accelerated growth in length, weight, and BMD was found. Among extremely preterm infants, relative to full-term infants, length was −6.77 cm (95 % CI: −7.14, −6.40; P for trend < 0.001) lower during the first 12 months; weight was −1.23 kg (−1.33, −1.13; P for trend < 0.001) lower; and BMD was −0.070 g/cm2(−0.087, −0.053; P for trend < 0.001) lower; however, average growth rates of these measures were higher (Ps < 0.05). Small gestational age and low birth weight were independently associated with lower length, weight, and BMD. Conclusion: Growth peaks in length and weight among preterm infants were observed at 1–3 months. No catch-up growth in length, weight, and BMD was observed, however, there was accelerated growth in length, weight, and BMD. Electronic supplementary material The online version of this article (doi:10.1186/s12887-015-0396-6) contains supplementary material, which is available to authorized users.Publication The Associations Between Consumption of Coffee and Soy Food With Health Outcomes.(2016-01-26) Ding, Ming; Hu, Frank; Giovannucci, Edward; Sun, Qi; Rosner, BernardObesity has become a global epidemic, and obesity prevalence rose from 4.8% to 9.8% in men and from 7.9% to 13.8% in women between 1980 and 2008 1. Preventing obesity and related chronic diseases, especially type 2 diabetes (T2D) and cardiovascular disease (CVD), is of crucial public health significance 2. Identification of dietary factors that are beneficial to health is of high priority. This dissertation focused on two kinds of foods, coffee and soy food, and their associations with obesity-related health outcomes. In Chapter 1, the association of coffee consumption with cardiovascular disease has been investigated in numerous epidemiological studies 3-5. However, a key issue that remains to be resolved is the dose-response relationship of long-term coffee consumption with CVD risk, including incidence of coronary heart disease, stroke, and heart failure, and CVD mortality. In the current study, I examined the association between coffee consumption and risk of CVD by meta-analyzing results from 36 prospective cohort studies with 1,279,804 study participants and 36,352 CVD cases. In Chapter 2, the study described in Chapter 1 showed that coffee consumption was non-linearly associated with risk of CVD: moderate coffee consumption was associated with lower risk of CVD, with the lowest CVD risk at 3 to 5 cups per day, and heavy coffee consumption was not associated with risk of CVD. However, whether the non-linear association was due to a true biological effect or confounding of smoking is not known. In this chapter, with 208,501 participants and 31,956 deaths in three large cohort studies, I prospectively examined the associations of coffee consumption with total mortality and cause-specific mortality among the overall population as well as never smokers. In Chapters 3 and 4, the association of isoflavone intake with risk of T2D has been assessed, and mixed results were observed 6-8. Clinical trials showed that isoflavone supplements did not improve glucose control 9-10, however, these clinical trials were limited by small sample size and short duration of follow-up. Therefore, I further examined the association of soy food with risk of type 2 diabetes. Two different approaches were used to assess soy food intake. First, soy food assessed by food frequency questionnaire (FFQ) was used as main exposure, and the association of soy food consumption with risk of type 2 diabetes was examined prospectively in three Harvard cohorts. Second, urinary isoflavones excretion was used as main exposure, and the association of urinary isoflavones concentration with risk of type 2 diabetes was assessed using a nested case-control design.Publication Time trends and risk factor associated with premature birth and infants deaths due to prematurity in Hubei Province, China from 2001 to 2012(BioMed Central, 2015) Xu, Haiqing; Dai, Qiong; Xu, Yusong; Gong, Zhengtao; Dai, Guohong; Ding, Ming; Duggan, Christopher; Hu, Zubin; Hu, FrankBackground: The nutrition and epidemiologic transition has been associated with an increasing incidence of preterm birth in developing countries, but data from large observational studies in China have been limited. Our study was to describe the trends and factors associated with the incidence of preterm birth and infant mortality due to prematurity in Hubei Province, China. Methods: We conducted a population-based survey through the Maternal and Child Health Care Network in Hubei Province from January 2001 to December 2012. We used data from 16 monitoring sites to examine the trend and risk factors for premature birth as well as infant mortality associated with prematurity. Results: A total of 818,481 live births were documented, including 76,923 preterm infants (94 preterm infants per 1,000 live births) and 2,248 deaths due to prematurity (2.75 preterm deaths per 1,000 live births). From 2001 to 2012, the incidence of preterm birth increased from 56.7 to 105.2 per 1,000 live births (P for trend < 0.05), while the infant mortality rate due to prematurity declined from 95.0 to 13.4 per 1,000 live births (P for trend < 0.05). Older maternal age, lower maternal education, use of assisted reproductive technology (ART), higher income, residence in urban areas, and infant male sex were independently associated with a higher incidence of preterm birth (all p values < 0.05). Shorter gestation, lower birth weight, and lower income were associated with a higher mortality rate, while use of newborn emergency transport services (NETS) was associated with a lower preterm mortality rate (all p values < 0.05). Conclusion: An increasing incidence of preterm birth and a parallel reduction in infant mortality due to prematurity were observed in Hubei Province from 2001 to 2012. Our results provide important information for areas of improvements in reducing incidence and mortality of premature birth. Electronic supplementary material The online version of this article (doi:10.1186/s12884-015-0767-x) contains supplementary material, which is available to authorized users.Publication Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts(2016) Ding, Ming; Pan, An; Manson, JoAnn; Willett, Walter; Malik, Vasanti; Rosner, Bernard; Giovannucci, Edward; Hu, Frank; Sun, QiBackground: Evidence regarding the consumption of soy foods and isoflavones in relation to risk of type 2 diabetes (T2D) is scarce. Objective: Our study was to evaluate the association between soy food and isoflavone consumption and risk of T2D in US men and women. Methods: We followed 63,115 women in the Nurses’ Health Study (1998-2012), 79,061 women in the Nurses’ Health Study II (1999-2013), and 21,281 men in the Health Professionals Follow-Up Study (2002-2010). Diet was assessed by a validated food-frequency questionnaire, and was updated every 4 y. Self-reports of incident T2D was confirmed by a validated supplementary questionnaire. Results: During 1,966,321 person-years of follow-up, 9,185 incident T2D cases were documented. After multivariate adjustment for covariates, consumption of soy foods (tofu and soy milk) was not associated with a lower T2D risk. Compared to non-consumers of soy foods, the hazard ratio (HR) was 1.00 (95% CI: 0.93, 1.07) for <1 serving/week, and 0.93 (95% CI: 0.83, 1.03) for ≥1 serving/week of soy foods (P for trend = 0.14). In contrast, intake of total isoflavones was inversely associated with T2D risk. Comparing extreme quintiles of isoflavones, the HR was 0.89 (95% CI: 0.83, 0.96; P for trend = 0.009). Inverse associations were also found for consumption of major individual isoflavones, including daidzein and genistein, with risk of T2D. Conclusions: Intake of isoflavones was associated with a modestly lower T2D risk in US men and women who typically consumed low to moderate amounts of soy foods. These findings warrant replications in other populations with similar soy intake levels.