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Suter, Melissa

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Suter

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Melissa

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Suter, Melissa

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2008 - 200912010 - 20187

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Author's Publications: search.filters.isAuthorOfPublication.d7b69c54-c2c2-4925-9019-6d67b2a373c8

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Now showing 1 - 8 of 8
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    Nano-optic endoscope for high-resolution optical coherence tomography in vivo
    (Springer Science and Business Media LLC, 2018-07-30) Pahlevaninezhad, Hamid; Khorasaninejad, Mohammadreza; Huang, Yao-Wei; Shi, Zhujun; Hariri, Lida P.; Adams, David C.; Ding, Vivien; Zhu, Alexander; Qiu, Cheng-Wei; Capasso, Federico; Suter, Melissa
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    High-resolution optical coherence tomography in vivo using a nano-optic endoscope
    (2018) Pahlevaninezhad, Hamid; Khorasaninejad, Mohammadreza; Huang, Yao-Wei; Shi, Zhujun; Hariri, Lida P.; Adams, David; Zhu, Alexander; Qiu, Cheng-Wei; Capasso, Federico; Suter, Melissa
    This work establishes a new class of endoscopic optical imaging catheters, termed nano-optic endoscopes, that uses metalenses with the ability to modify the phase of incident light at sub-wavelength level. We utilize the control of the phase and chromatic dispersion of the output beam to address two persistent limitations of optical imaging system, namely optical aberrations and the trade-off between transverse resolution and depth-of-focus. High-resolution endoscopic imaging at an extended depth-of-focus is demonstrated in resected human lung specimens and the airways of sheep in vivo. The nano-optic endoscope elevates the capabilities of endoscopic imaging in examining pathological changes in luminal tissue.
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    Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure
    (2012) Gora, Michalina J.; Sauk, Jenny S.; Carruth, Robert W.; Gallagher, Kevin A.; Suter, Melissa; Nishioka, Norman; Kava, Lauren E.; Rosenberg, Mireille; Bouma, Brett; Tearney, Guillermo
    Here, we introduce “tethered capsule endomicroscopy,” that involves swallowing an optomechanically-engineered pill that captures cross-sectional, 30 μm (lateral) × 7 μm (axial) resolution, microscopic images of the gut wall as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.
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    Comprehensive Microscopy of the Esophagus in Human Patients with Optical Frequency Domain Imaging
    (Elsevier BV, 2008) Suter, Melissa; Vakoc, Benjamin; Yachimski, Patrick S.; Shishkov, Milen; Lauwers, Gregory Y.; Mino-Kenudson, Mari; Bouma, Brett; Nishioka, Norman; Tearney, Guillermo
    Background: Optical coherence tomography (OCT) is a cross-sectional, high-resolution imaging modality that has been shown to accurately differentiate esophageal specialized intestinal metaplasia (SIM) from gastric cardia at the squamocolumnar junction (SCJ) and diagnose high-grade dysplasia and intramucosal carcinoma in patients with SIM. The clinical utility of OCT has been limited, however, by its inability to acquire images over large areas. Objective: The aim of this study was to use recently developed high-speed OCT technology, termed optical frequency domain imaging (OFDI), and a new balloon-centering catheter (2.5 cm diameter) to demonstrate the feasibility of large area, comprehensive optical microscopy of the entire distal esophagus (∼6.0 cm) in patients. Design: A pilot feasibility study. Setting: Massachusetts General Hospital. Patients: Twelve patients undergoing routine EGD. Results: Comprehensive microscopy of the distal esophagus was successfully performed in 10 patients with the OFDI system and balloon catheter. There were no complications resulting from the imaging procedure. Volumetric data sets were acquired in less than 2 minutes. OFDI images at the SCJ showed a variety of microscopic features that were consistent with histopathologic findings, including squamous mucosa, cardia, SIM with and without dysplasia, and esophageal erosion. Limitations: Inability to obtain direct correlation of OFDI data and histopathologic diagnoses. Conclusions: Comprehensive volumetric microscopy of the human distal esophagus was successfully demonstrated with OFDI and a balloon-centering catheter, providing a wealth of detailed information about the structure of the esophageal wall. This technique will support future studies to compare OFDI image information with histopathologic diagnoses.
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    Comprehensive Imaging of Gastroesophageal Biopsy Samples by Spectrally Encoded Confocal Microscopy
    (Elsevier BV, 2010) Kang, Dongkyun; Suter, Melissa; Boudoux, Caroline; Yoo, Hongki; Yachimski, Patrick S.; Puricelli, William P.; Nishioka, Norman; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Tearney, Guillermo
    Background: Spectrally encoded confocal microscopy (SECM) is a high-speed reflectance confocal microscopy technique that has the potential to be used for acquiring comprehensive images of the entire distal esophagus endoscopically with subcellular resolution. Objective: The goal of this study was to demonstrate large-area SECM in upper GI tissues and to determine whether the images contain microstructural information that is useful for pathologic diagnosis. Design: A feasibility study. Setting: Gastrointestinal Unit, Massachusetts General Hospital. Patients: Fifty biopsy samples from 36 patients undergoing routine EGD were imaged by SECM, in their entirety, immediately after their removal. Results: The microstructure seen in the SECM images was similar to that seen by histopathology. Gastric cardia mucosa was clearly differentiated from squamous mucosa. Gastric fundic/body type mucosa showed more tightly packed glands than gastric cardia mucosa. Fundic gland polyps showed cystically dilated glands lined with cuboidal epithelium. The presence of intraepithelial eosinophils was detected with the cells demonstrating a characteristic bilobed nucleus. Specialized intestinal metaplasia was identified by columnar epithelium and the presence of goblet cells. Barrett's esophagus (BE) with dysplasia was differentiated from specialized intestinal metaplasia by the loss of nuclear polarity and disorganized glandular architecture. Limitations: Ex vivo, descriptive study. Conclusions: Large-area SECM images of gastroesophageal biopsy samples enabled the visualization of both subcellular and architectural features of various upper GI mucosal types and were similar to the corresponding histopathologic slides. These results suggest that the development of an endoscopic SECM probe is merited.
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    Image-Guided Biopsy in the Esophagus through Comprehensive Optical Frequency Domain Imaging and Laser Marking: A Study in Living Swine
    (Elsevier BV, 2010) Suter, Melissa; Jillella, Priyanka A.; Vakoc, Benjamin; Halpern, Elkan F.; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Nishioka, Norman; Tearney, Guillermo
    Background: Random biopsy esophageal surveillance can be subject to sampling errors, resulting in diagnostic uncertainty. Optical frequency domain imaging (OFDI) is a high-speed, 3-dimensional endoscopic microscopy technique. When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes. Objective: To test a new platform for guided biopsy that allows the operator to select target regions of interest on an OFDI dataset, and then use a laser to mark the esophagus at corresponding locations. The specific goals include determining the optimal laser parameters, testing the accuracy of the laser marking process, evaluating the endoscopic visibility of the laser marks, and assessing the amount of mucosal damage produced by the laser. Design: Experimental study conducted in 5 swine in vivo. Setting: Massachusetts General Hospital. Main Outcome Measurements: Success rate, including endoscopic visibility of laser marks and accuracy of the laser marking process for selected target sites, and extent of the thermal damage caused by the laser marks. Results: All of the laser-induced marks were visible by endoscopy. Target locations were correctly marked with a success rate of 97.07% (95% confidence interval, 89.8%-99.7%). Thermal damage was limited to the superficial layers of the mucosa and was observed to partially heal within 2 days. Limitations: An animal study with artificially placed targets to simulate pathology. Conclusions: The study demonstrates that laser marking of esophageal sites identified in comprehensive OFDI datasets is feasible and can be performed with sufficient accuracy, precision, and visibility to guide biopsy in vivo.
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    Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    (Optical Society of America, 2012) Tan, K.M.; Shishkov, Milen; Chee, A.; Applegate, M. B.; Bouma, Brett; Suter, Melissa
    Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the catheter sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.
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    Co-Registered Spectrally Encoded Confocal Microscopy and Optical Frequency Domain Imaging System
    (Wiley-Blackwell, 2010) Kang, D.K.; Suter, Melissa; Boudoux, Caroline; Yachimski, P.S.; Puricelli, W.P.; Nishioka, Norman; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Tearney, Guillermo
    Spectrally encoded confocal microscopy and optical frequency domain imaging are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for histopathological diagnosis. Although spectrally encoded confocal microscopy has better transverse resolution than optical frequency domain imaging, optical frequency domain imaging can penetrate deeper into tissues, which potentially enables the visualization of different morphologic features. We have developed a co-registered spectrally encoded confocal microscopy and optical frequency domain imaging system and have obtained preliminary images from human oesophageal biopsy samples to compare the capabilities of these imaging techniques for diagnosing oesophageal pathology.