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Liu, Li

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Liu, Li

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2008 - 200912010 - 20141

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Author's Publications: search.filters.isAuthorOfPublication.dde63b1c-95b4-456b-8bb0-508dc08b4528

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    Nanophotonic quantum phase switch with a single atom
    (Nature Publishing Group, 2014) Tiecke, Tobias; Thompson, Jeffrey Douglas; de Leon, Nathalie Pulmones; Liu, Li; Vuletić, V.; Lukin, Mikhail
    By analogy to transistors in classical electronic circuits, quantum optical switches are important elements of quantum circuits and quantum networks1, 2, 3. Operated at the fundamental limit where a single quantum of light or matter controls another field or material system4, such a switch may enable applications such as long-distance quantum communication5, distributed quantum information processing2 and metrology6, and the exploration of novel quantum states of matter7. Here, by strongly coupling a photon to a single atom trapped in the near field of a nanoscale photonic crystal cavity, we realize a system in which a single atom switches the phase of a photon and a single photon modifies the atom’s phase. We experimentally demonstrate an atom-induced optical phase shift8 that is nonlinear at the two-photon level9, a photon number router that separates individual photons and photon pairs into different output modes10, and a single-photon switch in which a single ‘gate’ photon controls the propagation of a subsequent probe field11, 12. These techniques pave the way to integrated quantum nanophotonic networks involving multiple atomic nodes connected by guided light.
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    VAC14 Nucleates a Protein Complex Essential for the Acute Interconversion of PI3P and PI(3,5)P2 in Yeast and Mouse
    (Nature Publishing Group, 2008) Jin, Natsuko; Chow, Clement Y; Zolov, Sergey N; Davisson, Muriel; Petersen, Jason L; Zhang, Yanling; Park, Sujin; Duex, Jason E; Goldowitz, Daniel; Meisler, Miriam H; Weisman, Lois S; Liu, Li; Bronson, Roderick
    The signalling lipid PI(3,5)P2 is generated on endosomes and regulates retrograde traffic to the trans-Golgi network. Physiological signals regulate rapid, transient changes in PI(3,5)P2 levels. Mutations that lower PI(3,5)P2 cause neurodegeneration in human patients and mice. The function of Vac14 in the regulation of PI(3,5)P2 was uncharacterized previously. Here, we predict that yeast and mammalian Vac14 are composed entirely of HEAT repeats and demonstrate that Vac14 exerts an effect as a scaffold for the PI(3,5)P2 regulatory complex by direct contact with the known regulators of PI(3,5)P2: Fig4, Fab1, Vac7 and Atg18. We also report that the mouse mutant ingls (infantile gliosis) results from a missense mutation in Vac14 that prevents the association of Vac14 with Fab1, generating a partial complex. Analysis of ingls and two additional mutants provides insight into the organization of the PI(3,5)P2 regulatory complex and indicates that Vac14 mediates three distinct mechanisms for the rapid interconversion of PI3P and PI(3,5)P2. Moreover, these studies show that the association of Fab1 with the complex is essential for viability in the mouse.