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Liu, Jia

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Jia

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Liu, Jia

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2015 - 20162

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Author's Publications: search.filters.isAuthorOfPublication.de6672d2-3209-45a1-9903-3f95515e9d62

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    Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes
    (Nature Publishing Group, 2015) Xie, Chong; Liu, Jia; Fu, Tian-Ming; Dai, Xiaochuan; Zhou, Wei; Lieber, Charles
    Direct electrical recording and stimulation of neural activity using micro-fabricated silicon and metal micro-wire probes have contributed extensively to basic neuroscience and therapeutic applications; however, the dimensional and mechanical mismatch of these probes with the brain tissue limits their stability in chronic implants and decreases the neuron–device contact. Here, we demonstrate the realization of a three-dimensional macroporous nanoelectronic brain probe that combines ultra-flexibility and subcellular feature sizes to overcome these limitations. Built-in strains controlling the local geometry of the macroporous devices are designed to optimize the neuron/probe interface and to promote integration with the brain tissue while introducing minimal mechanical perturbation. The ultra-flexible probes were implanted frozen into rodent brains and used to record multiplexed local field potentials and single-unit action potentials from the somatosensory cortex. Significantly, histology analysis revealed filling-in of neural tissue through the macroporous network and attractive neuron–probe interactions, consistent with long-term biocompatibility of the device.
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    Buckling Induced Functionality in Soft Structures
    (2016-04-18) Liu, Jia; Bertoldi, Katia; Suo, Zhigang; Clarke, David R.
    A variety of instabilities can be triggered when elastic structures are subjected to mechanical loadings. While such instabilities have traditionally been considered as a failure, a new trend is emerging in which the dramatic geometric changes induced by them are harnessed to enable new functionalities. In this thesis, I report a systematic study on the morphology and functionality changes induced by buckling in soft structures. Using a combination of theoretical, numerical and experimental analyses, I investigate the non-linear response of a variety of one dimensional, two dimensional and three dimensional systems, with particular emphasis on their stability. The results show that the deformation induced by buckling can be rather complex even if the undeformed geometry is simple. Moreover, I demonstrate that a wide range of morphologies can be obtained by carefully controlling the geometric, material and loading parameters. Such tunability may open venues for the design of structures with adaptive and switchable properties.