Person: Douglass, Chester
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Publication Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma
(2013) Savage, Sharon A.; Mirabello, Lisa; Wang, Zhaoming; Gastier-Foster, Julie M.; Gorlick, Richard; Khanna, Chand; Flanagan, Adrienne M.; Tirabosco, Roberto; Andrulis, Irene L.; Wunder, Jay S.; Gokgoz, Nalan; Patiño-Garcia, Ana; Sierrasesúmaga, Luis; Lecanda, Fernando; Kurucu, Nilgün; Ilhan, Inci Ergurhan; Sari, Neriman; Serra, Massimo; Hattinger, Claudia; Picci, Piero; Spector, Logan; Barkauskas, Donald A.; Marina, Neyssa; de Toledo, Silvia Regina Caminada; Petrilli, Antonio S.; Amary, Maria Fernanda; Halai, Dina; Thomas, David M.; Douglass, Chester; Meltzer, Paul S.; Jacobs, Kevin; Chung, Charles C.; Berndt, Sonja I.; Purdue, Mark P.; Caporaso, Neil E.; Tucker, Margaret; Rothman, Nathaniel; Landi, Maria Teresa; Silverman, Debra T.; Kraft, Phillip; Hunter, David; Malats, Nuria; Kogevinas, Manolis; Wacholder, Sholom; Troisi, Rebecca; Helman, Lee; Fraumeni, Joseph F.; Yeager, Meredith; Hoover, Robert N.; Chanock, Stephen J.Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: rs1906953 at 6p21.3, in the glutamate receptor metabotropic 4 [GRM4] gene (P = 8.1 ×10-9), and rs7591996 and rs10208273 in a gene desert on 2p25.2 (P = 1.0 ×10-8 and 2.9 ×10-7). These two susceptibility loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.