Person: Taylor, George
Loading...
Email Address
AA Acceptance Date
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
Taylor
First Name
George
Name
Taylor, George
3 results
Search Results
Now showing 1 - 3 of 3
Publication A cross-sectional study of osteocalcin and body fat measures among obese adolescents(2016) Lenders, Carine M.; Lee, Phillip DK.; Feldman, Henry; Wilson, Darrell M.; Abrams, Stephanie H.; Gitelman, Stephen E.; Klish, William J; Wertz, Marcia S.; Taylor, George; Alongi, Richard T.; Chen, Tai C.; Holick, Michael F.Osteocalcin (OCN), a marker of osteoblast activity, has been implicated in the regulation of energy metabolism by the skeleton and thus may affect body fat measures. We examined the relationships of OCN to body fat measures and whether they vary according to markers of energy and vitamin D metabolism. Data was obtained from 58 obese adolescents aged 13–17.9 years (38 females, 8 black or African-American). We calculated total fat mass (FM) [dual X-ray absorptiometry (DXA)] and visceral adipose tissue (VAT) [computerized axial tomography (CT)]. Blood tests included leptin, OCN, 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), thyroid function tests, and triglycerides. Markers of glucose metabolism were obtained from fasting and OGTT samples. Adolescents with 25(OH)D<20 ng/mL were considered deficient (n=17/58); none had high PTH (PTH≥65 pg/mL). OCN was associated with lower VAT (−84.27±33.89 mm2) and BMI (−0.10±0.05 kg/m2), not FM (p=0.597) in a core model including age, sex, race, geographic latitude, summer, height z-score, and tanner stage. Adding 25(OH)D deficiency and PTH attenuated the inverse association of OCN to VAT. We found a significant interaction of OCN and 25(OH)D deficiency on FM (0.37±0.18 kg, p=0.041) and BMI (0.28±0.10 kg/m2, p=0.007) in this adjusted model, which was further explained by leptin. Adding A1C to the core model modified the relationship of OCN to VAT (−93.08±35.05 mm2, p=0.011), which was further explained by HOMA-IR. In summary, these findings provide evidence for a relationship between OCN and body fat measures that is dependent on energy metabolism and vitamin D status among obese adolescents.Publication Quality of Pediatric Abdominal CT Scans Performed at a Dedicated Children’s Hospital and Its Referring Institutions: A Multifactorial Evaluation(Springer Science and Business Media LLC, 2017-01-13) Snow, Aisling; Milliren, Carly E.; Graham, Dionne; Callahan, Michael; MacDougall, Robert D.; Robertson, Richard; Taylor, GeorgeBackground Pediatric patients requiring transfer to a dedicated children’s hospital from an outside institution may undergo CT imaging as part of their evaluation. Whether this imaging is performed prior to or after transfer has been shown to impact the radiation dose imparted to the patient. Other quality variables could also be affected by the pediatric experience and expertise of the scanning institution. Objective To identify differences in quality between abdominal CT scans and reports performed at a dedicated children’s hospital, and those performed at referring institutions. Materials and methods Fifty consecutive pediatric abdominal CT scans performed at outside institutions were matched (for age, gender and indication) with 50 CT scans performed at a dedicated freestanding children’s hospital. We analyzed the scans for technical parameters, report findings, correlation with final clinical diagnosis, and clinical utility. Technical evaluation included use of intravenous and oral contrast agents, anatomical coverage, number of scan phases and size-specific dose estimate (SSDE) for each scan. Outside institution scans were re-reported when the child was admitted to the children’s hospital; they were also re-interpreted for this study by children’s hospital radiologists who were provided with only the referral information given in the outside institution’s report. Anonymized original outside institutional reports and children’s hospital admission re-reports were analyzed by two emergency medicine physicians for ease of understanding, degree to which the clinical question was answered, and level of confidence in the report. Results Mean SSDE was lower (8.68) for children’s hospital scans, as compared to outside institution scans (13.29, P = 0.03). Concordance with final clinical diagnosis was significantly lower for original outside institution reports (38/48, 79%) than for both the admission and study children’s hospital reports (48/50, 96%; P = 0.005). Children’s hospital admission reports were rated higher than outside institution reports for completeness, ease of understanding, answering of clinical question, and level of confidence of the report (P < 0.001). Conclusion Pediatric abdominal CT scans performed and interpreted at a dedicated children’s hospital are associated with higher technical quality, lower radiation dose and a more clinically useful report than those performed at referring institutions.Publication Sonographic Findings in Bacterial Meningitis in Neonates and Young Infants(Springer-Verlag, 2007) Yikilmaz, Ali; Taylor, GeorgeCranial sonography plays an important role in the initial evaluation of infants with suspected bacterial meningitis and in monitoring for complications of the disease. Echogenic widening of the brain sulci, meningeal thickening and hyperemia suggest the diagnosis in an at-risk population. Sonography can identify the presence of extra-axial fluid collections, and color Doppler sonography can be very helpful in differentiating benign enlargement of subarachnoid spaces from subdural effusions. Intraventricular debris and stranding, and an irregular and echogenic ependyma are highly suggestive findings associated with ventriculitis. Sonography can play an important role in the detection of postinfectious hydrocephalus, in the determination of the level of obstruction, and in the evaluation of intracranial compliance. Focal or diffuse parenchymal involvement can represent parenchymal involvement by cerebritis, infarction, secondary hemorrhage or early abscess.