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Huang, Xudong

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Huang

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Xudong

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Huang, Xudong
Author's Publications: search.filters.isAuthorOfPublication.f304a3dd-485f-4d6a-866b-54719e4234e6End date: 2009Subject: search.filters.subject.5'-untranslated region

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    Physiological and Pathological Role of Alpha-Synuclein in Parkinson’s Disease through Iron Mediated Oxidative Stress; The Role of a Putative Iron-Responsive Element

    (Molecular Diversity Preservation International (MDPI), 2009) Olivares, David; Huang, Xudong; Branden, Lars; Greig, Nigel H.; Rogers, Jack

    Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer’s disease (AD) and represents a large health burden to society. Genetic and oxidative risk factors have been proposed as possible causes, but their relative contribution remains unclear. Dysfunction of alpha-synuclein ((\alpha)-syn) has been associated with PD due to its increased presence, together with iron, in Lewy bodies. Brain oxidative damage caused by iron may be partly mediated by (\alpha)-syn oligomerization during PD pathology. Also, (\alpha)-syn gene dosage can cause familial PD and inhibition of its gene expression by blocking translation via a newly identified Iron Responsive Element-like RNA sequence in its 5’-untranslated region may provide a new PD drug target.