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Salari, Keyan

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Salari

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Keyan

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Salari, Keyan

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2015 - 201912020 - 20211

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Author's Publications: search.filters.isAuthorOfPublication.f48de2cf-888b-4381-b111-61242d332e72

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    Biologically Informed Deep Neural Network for Prostate Cancer Discovery
    (Springer Science and Business Media LLC, 2021-09-22) Elmarakeby, Haitham A.; Hwang, Justin; Arafeh, Rand; Crowdis, Jett; Gang, Sydney; Liu, David; AlDubayan, Saud H.; Salari, Keyan; Kregel, Steven; Richter, Camden; Arnoff, Taylor E.; Park, Jihye; Hahn, William; Van Allen, Eliezer
    Determination of molecular features that mediate clinically aggressive phenotypes in prostate cancer remains a major biological and clinical challenge [1,2]. Recent advances in machine learning interpretability as applied to biomedical problems may enable discovery and prediction in clinical cancer genomics [3–5]. Here, we developed a biologically informed deep learning model (P-NET) to stratify prostate cancer patients by treatment resistance state and evaluate molecular drivers of treatment resistance for therapeutic targeting through complete model interpretability. We demonstrate that P-NET can predict cancer state using molecular data with a performance that is superior to other modeling approaches. Moreover, the biological interpretability within P-NET revealed established and novel molecularly altered candidates, such as MDM4 and FGFR1, that were implicated in predicting advanced disease and validated in vitro. Broadly, biologically informed fully interpretable neural networks enable preclinical discovery and clinical prediction in prostate cancer and may have general applicability across cancer types.
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    Evaluation and Treatment of a Ureterosciatic Hernia Causing Hydronephrosis and Renal Colic
    (Mary Ann Liebert, Inc., 2015) Salari, Keyan; Yura, Emily M.; Harisinghani, Mukesh; Eisner, Brian
    Abstract An 87-year-old female presented with complaints of intermittent severe right renal colic. CT imaging demonstrated a ureterosciatic hernia and moderate hydronephrosis proximal to the portion of the ureter that was herniated through the sciatic foramen. A retrograde pyelogram demonstrated a transition point in the ureter at the location of the hernia. A ureteral stent was placed resulting in straightening of the ureter, resolution of hydronephrosis, and complete resolution of the patient's symptoms.