Person: Dashti, Hassan
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Dashti
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Hassan
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Dashti, Hassan
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Publication Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes(Nature Publishing Group UK, 2018) Vera, Beatriz; Dashti, Hassan; Gómez-Abellán, Purificación; Hernández-Martínez, Antonio M.; Esteban, Alberto; Scheer, Frank; Saxena, Richa; Garaulet, MartaEvening chronotype associates with health complications possibly via lifestyle factors, while the contribution of genetics is unknown. The aim was to study the relative contributions of genetics, lifestyle, and circadian-related physiological characteristics in metabolic risk of evening chronotype. In order to capture a biological contribution to chronotype, a genetic-risk-score (GRS), comprised of 15 chronotype-related variants, was tested. Moreover, a wide range of behavioral and emotional eating factors was studied within the same population. Chronotype, lifestyle, and metabolic syndrome (MetS) outcomes were assessed (n = 2,126), in addition to genetics (n = 1,693) and rest-activity/wrist-temperature rhythms (n = 100). Evening chronotype associated with MetS and insulin resistance (P < 0.05), and several lifestyle factors including poorer eating behaviors, lower physical activity and later sleep and wake times. We observed an association between higher evening GRS and evening chronotype (P < 0.05), but not with MetS. We propose a GRS as a tool to capture the biological component of the inter-individual differences in chronotype. Our data show that several modifiable factors such as sedentary lifestyle, difficulties in controlling the amount of food eaten, alcohol intake and later wake and bed times that characterized evening-types, may underlie chronotype-MetS relationship. Our findings provide insights into the development of strategies, particularly for evening chronotype.Publication Nutritional Biomarkers, Gene-Diet Interaction, and Risk Factors for Type 2 Diabetes(Hindawi Publishing Corporation, 2016) Zheng, Ju-Sheng; Niu, Kaijun; Jacobs, Simone; Dashti, Hassan; Huang, TaoPublication Sleep Characteristics Across the Lifespan in 1.1 Million Persons From the General Population of the Netherlands, UK and USA(Springer, 2020-11-16) Kocevska, Desana; Lysen, Thom S; Dotinga, Aafje; Koopman-Verhoef, M. Elisabeth; Luijk, Maartje PCM; Antypa, Niki; Biermasz, Nienke; Blokstra, Anneke; Brug, Johannis; Burk, William J.; Comijs, Hannie C.; Corpeleijn, Eva; Dashti, Hassan; de Bruin, Eduard J.; de Graaf, Ron; Derks, Ivonne P.M.; Dewald-Kaufmann, Julia F.; Elders, Petra J.M.; Reinoldus, J. B. J. Gemke; Grievink, Linda; Hale, Lauren; Hartman, Catharina A.; Heijnen, Cobi J.; Huisman, Martijn; Huss, Anke; Ikram, M. Arfan; Jones, Samuel E.; Klein Velderman, Mariska; Konig, Maaike; Meijer, Anne Marie; Noordham, Raymond; Oldehinkel, Albertine J.; Groeniger, Joost Oude; Penninx, Brenda W.J.H.; Picavet, H. Susan J.; Pieters, Sara; Reijneveld, Sijmen A.; Reitz, Ellen; Renders, Carry M.; Rodenburg, Gerda; Rutters, Femke; Smith, Matthew C.; Singh, Amika S.; Snijder, Marieke B.; ten Have, Margreet; Twisk, J. W. R.; Mheen, Dike Van de; van der Ende, Jan; van der Heiden, Kristiaan B.; van der Velden, Peter G.; van Lenthe, Frank J.; van Litsenburg, Raphaële R. L.; van Oostrom, Sandra H.; van Schalkwijk, Frank J.; Sheehan, Connor; Verheij, Robert A.; Verhulst, F. C.; Vermeulen, Marije C. M.; Vermeulen, Roel C. H.; Verschuren, W M Monique; Vrijkotte, Tanja G. M.; Wijga, Alet; Willemen, Agnes M.; Wolbeek, Maike ter; Wood, Andrew R.; Xerxa, Yllza; Bramer, Wichor M.; Franco, Oscar H.; Luik, Annemarie I.; Van Someren, Eus J. W.; Tiemeier, HenningObjectives. The study has three main objectives: 1) to obtain reliable reference charts for sleep duration; 2) estimate the prevalence of sleep complaints in the general population across the lifespan; and 3) to identify risk indicators of poor sleep. Design. Systematic review and meta-analysis of individual participant data (IPD). Data sources. Studies identified through systematic literature search in Embase, Medline and Web of Science (August 9th 2019), and through personal contacts with colleagues in the UK and US. Eligibility criteria. Studies eligible for IPD meta-analysis had to be published between 2000 and 2017 with data on sleep characteristics assessed with questionnaires that sampled ≥100 participants from the general population of the Netherlands. Large population-based studies/surveys from UK and US were included for comparisons. Data synthesis. For IPD analysis, data were obtained for 36 out of 47 eligible studies. Two researchers independently coded sleep variables: (time in bed (TIB), sleep duration (Total Sleep Time, TST), sleep efficiency (TST/TIB*100)), self/caregiver-reported sleep quality, insomnia symptoms and other sleep complaints, as well as socio-demographic characteristics (sex, age, education, ethnic origin, employment and partnership status) and health risk indicators (smoking and body mass index). All variables were coded following a standardized protocol. For comparison, complementary sleep data from the UK Biobank and the National Health Interview Survey in the USA were included. Where available, actigraphic sleep estimates were obtained using validated algorithms. Results. We assembled IPD from 200,358 persons (age range 1-100 years, 55% female) from the Netherlands, 471,759 persons (40 to 69 years old, 55.5% female) from the UK, and 409,617 persons (≥18 years, 55.8% female) from the US. Age-specific percentile curves for TST demonstrate that overall 24.5% of the studied population slept less than age-specific recommendations, but only 5.8% slept outside of the “acceptable range” for sleep duration. Short sleep duration was most prevalent in teenagers, as 51.5% reported TST less than the recommended 8-10 hours and 18% report daytime sleepiness. In adults (≥18yrs), poor sleep quality (13.3%) and insomnia symptoms (9.6-19.4%) were more prevalent than short sleep duration (6.5% with TST<6 hours). Insomnia symptoms were least frequent in 26-to-40-year-olds and most frequent in persons aged >65 years, and those spending 9 or more hours in bed. Poor sleep quality was most common in those spending <6 hours in bed. Women, persons of non-European origin, overweight persons and smokers were more prone to poor sleep. While habitual TST was similar in the different countries, insomnia symptoms were between 1.5 to 2.9 times higher in USA than in the Netherlands. Women (41+) reported sleeping shorter or slightly less efficient than men, which was opposite to actigraphy estimates where women were estimated to sleep longer and more efficiently than man, both in the UK and in the Netherlands. Conclusion. In the largest descriptive sleep study to date, we provide age- and sex-specific population reference charts for sleep duration and efficiency which can be used in research, clinical and preventive in industrialized countries. More people report poor sleep quality than short sleep duration. Thus, whereas most available guidelines address optimal sleep duration, our findings highlight the importance of also targeting sleep quality.