Publication:
Apicobasal polarization: epithelial form and function

No Thumbnail Available

Date

2003

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier
The Harvard community has made this article openly available. Please share how this access benefits you.

Research Projects

Organizational Units

Journal Issue

Citation

Gibson, Matthew C, and Norbert Perrimon. 2003. “Apicobasal Polarization: Epithelial Form and Function.” Current Opinion in Cell Biology 15 (6): 747–52. https://doi.org/10.1016/j.ceb.2003.10.008.

Research Data

Abstract

The structure and function of epithelial sheets generally depend on apicobasal polarization, which is achieved and maintained by linking asymmetrically distributed intercellular junctions to the cytoskeleton of individual cells. Recent studies in both Drosophila and vertebrate epithelia have yielded new insights into the conserved mechanisms by which apicobasal polarity is established and maintained during development. In mature polarized epithelia, apicobasal polarity is important for the establishment of adhesive junctions and the formation of a paracellular diffusion barrier that prevents the movement of solutes across the epithelium. Recent findings show that segregation of ligand and receptor with one on each side of this barrier can be a crucial regulator of cell-cell signaling events.

Description

Other Available Sources

Keywords

Terms of Use

Metadata Only

Endorsement

Review

Supplemented By

Referenced By

Related Stories