Drosophila Jun Relays the Jun Amino-Terminal Kinase Signal Transduction Pathway to the Decapentaplegic Signal Transduction Pathway in Regulating Epithelial Cell Sheet Movement
Date
July 1, 1997
Author(s)
Hou, Steven X.
Goldstein, Elliott S.
Publisher
Cold Spring Harbor Laboratory
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Citation
Hou, Steven X., Elliott S. Goldstein, Norbert Perrimon. "Drosophila Jun Relays the Jun Amino-Terminal Kinase Signal Transduction Pathway to the Decapentaplegic Signal Transduction Pathway in Regulating Epithelial Cell Sheet Movement." Genes & Development 11, no. 13 (1997): 1728-1737. DOI: 10.1101/gad.11.13.1728
Abstract
We have characterized mutations in the Drosophila homolog of the mammalian proto-oncogene c-Jun gene (Djun). We demonstrate that DJUN in the embryo is a downstream target of the JNK signal transduction pathway during dorsal closure formation, and that the function of the JNK/DJUN pathway is to control the localized expression of decapentalegic (dpp), a member of the TGF-beta growth factor family. In contrast to previous observations, we find that both in the embryo and during photoreceptor cell determination, DJUN is not regulated by a pathway that involves MAPK.
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