Publication: Novel locus including FGF21 is associated with dietary macronutrient intake
No Thumbnail Available
Open/View Files
Date
2013
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Chu, Audrey Y., Tsegaselassie Workalemahu, Nina P. Paynter, Lynda M. Rose, Franco Giulianini, Toshiko Tanaka, Julius S. Ngwa, et al. 2013. “Novel Locus Including FGF21 Is Associated with Dietary Macronutrient Intake.” Human Molecular Genetics 22 (9): 1895–1902. https://doi.org/10.1093/hmg/ddt032.
Research Data
Abstract
Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top associations (P 10(5)) for percentage of total caloric intake from protein and carbohydrate. rs838133 was replicated in silico in an independent sample from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) Nutrition Working Group (n 38 360) and attained genome-wide significance in combined analysis (P-joint 7.9 10(9)). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake.
Description
Other Available Sources
Keywords
Terms of Use
Metadata Only