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Dependence of antibody-mediated presentation of antigen on FcRn

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2008

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10.1073/pnas.0801717105

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National Academy of Sciences
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Qiao, S.-W., K. Kobayashi, F.-E. Johansen, L. M. Sollid, J. T. Andersen, E. Milford, D. C. Roopenian, W. I. Lencer, and R. S. Blumberg. 2008. “Dependence of Antibody-Mediated Presentation of Antigen on FcRn.” Proceedings of the National Academy of Sciences 105 (27): 9337–42. https://doi.org/10.1073/pnas.0801717105.

Abstract

The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41483440

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